miR-142-3p Suppresses Invasion and Adhesion of Mesothelioma Cells by Downregulating ITGAV
Conclusion: This study proposed that the miR-142-3p/ITGAV axis is involved in tumor progression in malignant mesothelioma.Pathobiology (Source: Pathobiology)
Source: Pathobiology - February 1, 2023 Category: Pathology Source Type: research
Cancer registration, molecular marker status and adherence to the WHO 2016 classification of pathology reports for glioma diagnosed during 2017-2019 in Belgium
Conclusion:
Both the integration of molecular markers in the conclusion of the pathology reports and the delivery of those reports to the BCR can be improved. The availability of distinct ICD-O-3 codes for each molecularly defined tumour entity within the WHO classification would increase the consistency of cancer registration, facilitate population level research and international benchmarking. (Source: Pathobiology)
Source: Pathobiology - January 26, 2023 Category: Pathology Source Type: research
Renal cell carcinoma in end-stage renal disease: A retrospective study in patients from Hungary
Conclusion: In our cohort, the most common RCC subtype was clear cell RCC (55%), with a frequency that exceeded international data appreciably (14-25%). The incidence of clear cell papillary tumor and ACKD RCC (14.7% and 8.5%) was lower than data reported in the literature (30% and 40%). Our results indicate a favorable prognosis of RCC in ESRD. (Source: Pathobiology)
Source: Pathobiology - January 25, 2023 Category: Pathology Source Type: research
GATA3 Expression in Human Tumors: A Tissue Microarray Study on 16,557 Tumors
Conclusion: Our data demonstrate that GATA3 positivity can occur in various tumor entities. Low levels of GATA3 reflect cancer progression and poor patient prognosis in breast cancer.Pathobiology (Source: Pathobiology)
Source: Pathobiology - January 17, 2023 Category: Pathology Source Type: research
Evaluation of the Implementation and Diagnostic Accuracy of the Paris Classification for Reporting Urinary Cytology in Voided Urine Specimens: A Cyto-Histological Correlation Study in a Cancer Center
Conclusion: Specificity of urinary cytology was very high (with only 1 false-positive result), which is important since this will trigger a clinical intervention. The ROHM for each category was in accordance with literature, except for AUC where ROHM was slightly higher (66.7%). This may be explained by the study population characteristics (cancer center; many patients treated with intravesical therapies; lack of clinical annotation for patients referred from outside institutions).Pathobiology (Source: Pathobiology)
Source: Pathobiology - December 27, 2022 Category: Pathology Source Type: research
Contents, Vol. 89, 2022
Pathobiology 2022;89:I –IV (Source: Pathobiology)
Source: Pathobiology - December 13, 2022 Category: Pathology Source Type: research
Acknowledgement to Reviewers
Pathobiology 2022;89:418 (Source: Pathobiology)
Source: Pathobiology - December 13, 2022 Category: Pathology Source Type: research
Flow Cytometry Analysis Reveals a Wide Cytologic and Immunophenotypic Spectrum of Peripheral B Lymphocytes in Angioimmunoblastic T-Cell Lymphoma
Conclusions: Our results demonstrated a wide spectrum of peripheral B-cell morphologies and immunophenotypes of peripheral B cells in AITL. These findings correspond to dysregulated B-cell immunity and heterogeneous clinicopathological features.Pathobiology (Source: Pathobiology)
Source: Pathobiology - November 24, 2022 Category: Pathology Source Type: research
Lymphocyte Subsets in Cervicovaginal Lavage Specimens of HIV-Infected Women: A Surrogate Risk Marker of HPV-Associated Cervical Lesions
Conclusion: Cervical lymphoid populations can be characterized by flow cytometry, showing a distinct cervical T-cell compartment in HIV+ women. This may represent a surrogate risk marker of HPV-associated cervical lesions in this population and prompt further research on this subject, contributing to improving patients ’ management.Pathobiology (Source: Pathobiology)
Source: Pathobiology - October 27, 2022 Category: Pathology Source Type: research
Prevalence of Molecular Alterations in a Swiss Cohort of 512 Colorectal Carcinoma Patients by Targeted Next-Generation Sequencing Analysis in Routine Diagnostics
Conclusions: Our analysis revealed the prevalence of potential predictive markers in a large cohort of CRC patients obtained during routine diagnostic analysis. Furthermore, our study is the first of this size to uncover the molecular landscape of CRC in Switzerland.Pathobiology (Source: Pathobiology)
Source: Pathobiology - October 6, 2022 Category: Pathology Source Type: research
Prelims
Pathobiology 2022;89:259 –260 (Source: Pathobiology)
Source: Pathobiology - October 3, 2022 Category: Pathology Source Type: research
Evolutionary Changes in Pathology and Our Understanding of Disease
The history of pathology involves human dissections, autopsies, microscopy, as well as the development of histopathological, immunohistochemical, and molecular techniques. Through these methods, our understanding of anatomy and disease improved, and models of pathogenesis were gradually refined over time. This review discusses key milestones in the development of pathology as a branch of medical science, from ancient civilizations to the modern day.Pathobiology (Source: Pathobiology)
Source: Pathobiology - August 23, 2022 Category: Pathology Source Type: research
A Comparison of Tissue Dissection Techniques for Diagnostic, Prognostic, and Theragnostic Analysis of Human Disease
Histopathology has historically been the critical technique for the diagnosis and treatment of human disease. Today, genomics, transcriptomics, and proteomics from specific cells, rather than bulk tissue, have become key to understanding underlying disease mechanisms and rendering useful diagnostic information. Extraction of desired analytes, i.e., nucleic acids or proteins, from easily accessible formalin-fixed paraffin-embedded tissues allows for clinically relevant activities, such as sequencing biomarker mutations or typing amyloidogenic proteins. Genetic profiling has become routine for cancers as varied as non-small ...
Source: Pathobiology - August 11, 2022 Category: Pathology Source Type: research
The More Extensive the Spread through Air Spaces, the Worse the Prognosis Is: Semi-Quantitative Evaluation of Spread through Air Spaces in Pulmonary Adenocarcinomas
Discussion: More extensive STAS is an unfavourable prognostic factor in adenocarcinomas treated with sublobar resection. As the evaluation of extent of STAS is reproducible, further investigation is required to gather more evidence.Pathobiology (Source: Pathobiology)
Source: Pathobiology - August 10, 2022 Category: Pathology Source Type: research
Erratum
Pathobiology (Source: Pathobiology)
Source: Pathobiology - July 28, 2022 Category: Pathology Source Type: research
