Prelims
Pathobiology 2021;88:7 –10 (Source: Pathobiology)
Source: Pathobiology - January 20, 2021 Category: Pathology Source Type: research

CXC Chemokine Receptor Type 5 Gene Polymorphisms in a Cohort of Egyptian Patients with Diffuse Large B-Cell Lymphoma
Conclusions:CXCR5 gene polymorphisms could be considered a potential risk factor for the development of DLBCL.Pathobiology (Source: Pathobiology)
Source: Pathobiology - December 30, 2020 Category: Pathology Source Type: research

Microbiome: A Supportive or a Leading Actor in Lung Cancer?
Lung cancer is still the leading cause of cancer death worldwide. Despite the major diagnostic and therapeutic innovations, the effect on mortality has been modest and the overall survival is still poor. Better understanding of the pathology of these tumors is necessary in order to develop personalized therapeutic strategies in lung cancer patients. Human microbiome has been associated with normal physiology and function, and increasing evidence points towards a key role of the microbiome in promoting the progression of lung disease. Studies have shown that although poorly understood, lung has a distinctive microbiome that...
Source: Pathobiology - December 22, 2020 Category: Pathology Source Type: research

Investigations of Pathologists as a Key to Understanding Coronavirus Disease 2019
Pathobiology (Source: Pathobiology)
Source: Pathobiology - December 18, 2020 Category: Pathology Source Type: research

Publisher's Note
Pathobiology (Source: Pathobiology)
Source: Pathobiology - December 18, 2020 Category: Pathology Source Type: research

Goodbye and Thank You
Pathobiology (Source: Pathobiology)
Source: Pathobiology - December 18, 2020 Category: Pathology Source Type: research

New Editor-in-Chief of < b > < i > Pathobiology < /i > < /b > , the Journal of Translational Pathology
Pathobiology (Source: Pathobiology)
Source: Pathobiology - December 17, 2020 Category: Pathology Source Type: research

Tumor-Infiltrating T Cells Concurrently Overexpress CD200R with Immune Checkpoints PD-1, CTLA-4, and TIM-3 in Non-Small-Cell Lung Cancer
Conclusions: Our results showed that those tumors were dominated by T cells expressing CD200R together with other checkpoints, which suggests a phenotypic change after T cell infiltration into the tumor, such as T cell exhaustion.Pathobiology (Source: Pathobiology)
Source: Pathobiology - December 15, 2020 Category: Pathology Source Type: research

Contents, Vol. 87, 2020
Pathobiology 2020;87:I –IV (Source: Pathobiology)
Source: Pathobiology - December 15, 2020 Category: Pathology Source Type: research

Acknowledgement to Reviewers
Pathobiology 2020;87:375 –376 (Source: Pathobiology)
Source: Pathobiology - December 15, 2020 Category: Pathology Source Type: research

Biosafety Requirements for Autopsies of Patients with COVID-19: Example of a BSL-3 Autopsy Facility Designed for Highly Pathogenic Agents
Information obtained from autopsies of patients infected with high-risk pathogens is an important pillar in managing a proper response to pandemics, particular in the early phase. This is due to the fact that autopsy allows efficient evaluation of comorbidities for risk assessment, as well as identification of key pathophysiological and molecular mechanisms in organs driving the severity of disease which might be important targets for therapeutic interventions. In the case of patients who have died of infection with unknown pathogens, isolation and culture of pathogens from the affected organs is another important opportun...
Source: Pathobiology - December 9, 2020 Category: Pathology Source Type: research

The Upper Digestive Tract Microbiome and Oesophageal Squamous Cell Carcinoma: Epidemiology, Pathogenesis, and Clinical Implications in Africa
The study of the microbiome has significantly contributed to our understanding of complex diseases including cancer, with a profound influence of the microbiota on clinical prognosis and the efficacy of cancer treatments. Oesophageal cancer is positioned amongst the most aggressive malignant diseases, resulting from a complex interaction between anthropometric, genetic, immune response, and environmental factors. Oesophageal squamous cell carcinoma (OSCC) is the most common type of oesophageal cancer and is a serious burden in Eastern Africa, in the area known as the African oesophageal cancer corridor (AOCC). OSCC is ofte...
Source: Pathobiology - December 8, 2020 Category: Pathology Source Type: research

The Role of < b > < i > Fusobacterium nucleatum < /i > < /b > in Colorectal Carcinogenesis
Colorectal cancer (CRC) is one of the most frequent and deadly neoplasms worldwide. Genetic factors, lifestyle habits, and inflammation are important risk factors associated with CRC development. In recent years, growing evidence has supporting the significant role of the intestinal microbiome in CRC carcinogenesis. Disturbances in the healthy microbial balance, known as dysbiosis, are frequently observed in these patients. Pathogenic microorganisms that induce intestinal dysbiosis have become an important target to determine the role of bacterial infection in tumorigenesis. Interestingly, the presence of different bacteri...
Source: Pathobiology - December 8, 2020 Category: Pathology Source Type: research

miR-6838-5p Affects Cell Growth, Migration, and Invasion by Targeting GPRIN3 via the Wnt/ β-Catenin Signaling Pathway in Gastric Cancer
Gastric cancer (GC) is a highly prevalent digestive malignant tumor, ranking second in the tumor-related mortality globally. The microRNAs have been confirmed to be connected with GC progression. Accumulative evidence has suggested that miR-6838-5p exerts a suppressive effect on human cancers. Nonetheless, whether miR-6838-5p is involved in the regulation of GC remains to be investigated. During our research, miR-6838-5p was downregulated in GC cells. Upregulated miR-6838-5p repressed GC cell cycle progression, proliferation, migration, and invasion. Furthermore, miR-6838-5p overexpression repressed the nuclear import of ...
Source: Pathobiology - November 30, 2020 Category: Pathology Source Type: research

COVID-19 Autopsies: A Case Series from Poland
This study revealed thrombotic complications of COVID-19 and interstitial pneumonia with DAD presence as the main autopsy findings in patients with SARS-CoV-2 infection that was confirmed antemortem with molecular tests. Autopsy studies using tissue sections handled in accordance withSARS-CoV-2 biosafety guidelines are urgently needed, especially in the case of subjects who were below the age of 60.Pathobiology (Source: Pathobiology)
Source: Pathobiology - November 30, 2020 Category: Pathology Source Type: research