Increased Risk of Atherosclerosis in Patients with Sarcoidosis
Sarcoidosis is a systemic granulomatous disease of unknown etiology. Recent studies demonstrated that its pathogenesis is related with enhanced oxidative stress (protein carbonylation and lipid peroxidation) and alterations in the circulating lipid profile. Alterations of lipid metabolism (including the reduction in high-density lipoprotein cholesterol levels and apolipoprotein A1 concentrations) induce plasma membrane, bronchial and lung capillary endothelial cell damage in sarcoidosis patients. Dyslipidemia is associated with increased oxidative stress, diminished overall antioxidative protection and increased risk for a...
Source: Pathobiology - October 25, 2017 Category: Pathology Source Type: research
Cytoplasmic Lipid Accumulation Characteristic of the Cribriform Variant of Papillary Thyroid Carcinoma
Conclusion: This is the first study to report the presence of carcinoma cells with CLIA in CV-PTC. The subnuclear dot-like expression of adipophilin may be characteristic of CV-PTC. These findings might be related to degenerative changes occurring in CV-PTC.Pathobiology (Source: Pathobiology)
Source: Pathobiology - October 25, 2017 Category: Pathology Source Type: research
Role of Next-Generation Sequencing as a Diagnostic Tool for the Evaluation of Bone and Soft-Tissue Tumors
Bone and soft-tissue tumors are in general rare. Diagnosing these tumors is challenging based on the significant number of different tumor entities, the rareness of these tumors, and the considerable morphological heterogeneity which can be found within a single tumor entity. Considering that more than half of the described soft-tissue tumors and approximately 25% of the bone tumors harbor recurrent genetic alterations, the use of auxiliary molecular examinations should be strongly considered. Molecular analyses are important to confirm the diagnosis, to guide treatment, to provide information about prognosis, and to allow...
Source: Pathobiology - October 25, 2017 Category: Pathology Source Type: research
Chrysotile Causes Human Bronchial Epithelial Cell Apoptosis in Response to the Fas-Mediated Apoptosis Pathway
Conclusion: Chrysotile causes the apoptosis of BEAS-2B cells via the Fas death receptor pathway. The Fas-mediated apoptosis pathway plays an important role in chrysotile-induced apoptosis of BEAS-2B cells in vitro.Pathobiology (Source: Pathobiology)
Source: Pathobiology - October 25, 2017 Category: Pathology Source Type: research
Salivary Gland Neoplasms: Does Morphological Diversity Reflect Tumor Heterogeneity
Salivary gland tumor classification encompasses a vast list of benign and malignant neoplasms. Their morphological diversity is recognized not only between different entities but also within individual tumors. Tumor categories as described by the World Health Organization reflect, in part, a true genetic heterogeneity (e.g., translocations involvingCRTC1andCRTC3-MAML2 genes in mucoepidermoid carcinoma andMYB-NFIB fusion in adenoid cystic carcinoma). Carcinoma ex pleomorphic adenoma shows diversity in its histological appearance, but recurrent rearrangements onPLAG1 andHMGA2 are common to its benign precursor. More recently...
Source: Pathobiology - October 25, 2017 Category: Pathology Source Type: research
Next-Generation Sequencing in Gynaecological Tumours: The Prognostic and Predictive Value of the Most Common Mutations Found in Ovarian, Endometrial, and Cervical Tumours: Literature Review and the University Medical Centre Utrecht Next-Generation Sequencing Data
Conclusion: In the ovaryKRAS mutation is associated with type I ovarian tumours (low-grade serous, mucinous, endometrioid, and clear-cell) and may seem to have a more favourable prognosis. The prognostic value ofTP53 is still controversial. In endometrial tumours,PTEN shows a positive correlation with better prognosis.PIK3CA may have a correlation with poorer prognosis.CTNNB1 mutations in endometrial carcinomas could predict a worse prognosis.Pathobiology (Source: Pathobiology)
Source: Pathobiology - October 25, 2017 Category: Pathology Source Type: research
Survey of KI, WU, MW, and STL Polyomavirus in Cancerous and Non-Cancerous Lung Tissues
Conclusion: Neither of the viruses was found in samples from small-cell, non-small-cell (adenocarcinoma, squamous-cell carcinoma and large-cell neuroendocrine lung cancer), mixed-type and non-differentiated lung carcinoma, and non-cancerous lung tissues (from patients with pneumonia, emphysema and fibrosis).Pathobiology (Source: Pathobiology)
Source: Pathobiology - October 25, 2017 Category: Pathology Source Type: research
Ovarian Cancer: A Heterogeneous Disease
We describe the morphological and molecular heterogeneity among ovarian cancers and discuss recent advances in our understanding of intratumor heterogeneity.Pathobiology (Source: Pathobiology)
Source: Pathobiology - October 25, 2017 Category: Pathology Source Type: research
The Landscape of Circulating Tumor Cell Research in the Context of Epithelial-Mesenchymal Transition
The metastatic spread of cancer accounts for the vast majority of cancer-related deaths. It is mediated by tumor cells circulating in blood (called circulating tumor cells, CTCs), which escaped from their established niches. CTCs give a unique opportunity to look into the metastatic cascade and to study the molecular processes supporting the spread of tumor cells throughout the body. As current therapies are not sufficiently effective in treating metastatic disease, it is important to determine cellular and molecular features of cancer cells that “seed” new tumors in distant organs at early stages. In this review we fo...
Source: Pathobiology - October 25, 2017 Category: Pathology Source Type: research
Ovarian Cancer: A Heterogeneous Disease
We describe the morphological and molecular heterogeneity among ovarian cancers and discuss recent advances in our understanding of intratumor heterogeneity.Pathobiology (Source: Pathobiology)
Source: Pathobiology - October 11, 2017 Category: Pathology Source Type: research
Survey of KI, WU, MW, and STL Polyomavirus in Cancerous and Non-Cancerous Lung Tissues
Conclusion: Neither of the viruses was found in samples from small-cell, non-small-cell (adenocarcinoma, squamous-cell carcinoma and large-cell neuroendocrine lung cancer), mixed-type and non-differentiated lung carcinoma, and non-cancerous lung tissues (from patients with pneumonia, emphysema and fibrosis).Pathobiology (Source: Pathobiology)
Source: Pathobiology - September 29, 2017 Category: Pathology Source Type: research
Next-Generation Sequencing in Gynaecological Tumours: The Prognostic and Predictive Value of the Most Common Mutations Found in Ovarian, Endometrial, and Cervical Tumours: Literature Review and the University Medical Centre Utrecht Next-Generation Sequencing Data
Conclusion: In the ovaryKRAS mutation is associated with type I ovarian tumours (low-grade serous, mucinous, endometrioid, and clear-cell) and may seem to have a more favourable prognosis. The prognostic value ofTP53 is still controversial. In endometrial tumours,PTEN shows a positive correlation with better prognosis.PIK3CA may have a correlation with poorer prognosis.CTNNB1 mutations in endometrial carcinomas could predict a worse prognosis.Pathobiology (Source: Pathobiology)
Source: Pathobiology - September 25, 2017 Category: Pathology Source Type: research
Salivary Gland Neoplasms: Does Morphological Diversity Reflect Tumor Heterogeneity
Salivary gland tumor classification encompasses a vast list of benign and malignant neoplasms. Their morphological diversity is recognized not only between different entities but also within individual tumors. Tumor categories as described by the World Health Organization reflect, in part, a true genetic heterogeneity (e.g., translocations involvingCRTC1andCRTC3-MAML2 genes in mucoepidermoid carcinoma andMYB-NFIB fusion in adenoid cystic carcinoma). Carcinoma ex pleomorphic adenoma shows diversity in its histological appearance, but recurrent rearrangements onPLAG1 andHMGA2 are common to its benign precursor. More recently...
Source: Pathobiology - September 21, 2017 Category: Pathology Source Type: research
Salivary Gland Neoplasms: Does Morphological Diversity Reflect Tumor Heterogeneity?
Salivary gland tumor classification encompasses a vast list of benign and malignant neoplasms. Their morphological diversity is recognized not only between different entities but also within individual tumors. Tumor categories as described by the World Health Organization reflect, in part, a true genetic heterogeneity (e.g., translocations involvingCRTC1andCRTC3-MAML2 genes in mucoepidermoid carcinoma andMYB-NFIB fusion in adenoid cystic carcinoma). Carcinoma ex pleomorphic adenoma shows diversity in its histological appearance, but recurrent rearrangements onPLAG1 andHMGA2 are common to its benign precursor. More recently...
Source: Pathobiology - September 20, 2017 Category: Pathology Source Type: research
