Tumor Heterogeneity in Colorectal Cancer: What Do We Know So Far?
This article gives an overview of all of the current known data with regard to tumor heterogeneity at both inter- and intratumoral levels.Pathobiology (Source: Pathobiology)
Source: Pathobiology - February 7, 2018 Category: Pathology Source Type: research
Heterogeneity of Thyroid Cancer
There are 5 main histological types of thyroid cancers (TCs): papillary, follicular (also known as differentiated), poorly differentiated, anaplastic (the most aggressive form), and medullary TC, and only the latter arises from thyroid C cells. These different forms of TCs show significant variability, both among and within tumours. This great variation is particularly notable among the first 4 types, which all originate from thyroid follicular cells. Importantly, this heterogeneity is not limited to histopathological diversity only but is also manifested as variation in several genetic and/or epigenetic alterations, the n...
Source: Pathobiology - February 6, 2018 Category: Pathology Source Type: research
Author Index/Subject Index
Pathobiology 2017;84:351 –351 (Source: Pathobiology)
Source: Pathobiology - January 30, 2018 Category: Pathology Source Type: research
The Heterogeneity of Prostate Cancer: A Practical Approach
Prostate cancer is a paradigm tumor model for heterogeneity in almost every sense. Its clinical, spatial, and morphological heterogeneity divided by the high-level molecular genetic diversity outline the complexity of this disease in the clinical and research settings. In this review, we summarize the main aspects of prostate cancer heterogeneity at different levels, with special attention given to the spatial heterogeneity within the prostate, and to the standard morphological heterogeneity, with respect to tumor grading and modern classifications. We also cover the complex issue of molecular genetic heterogeneity, discus...
Source: Pathobiology - January 30, 2018 Category: Pathology Source Type: research
Prelims PAT 2017, Vol. 84, No. 6
Pathobiology 2017;84:285 –288 (Source: Pathobiology)
Source: Pathobiology - January 23, 2018 Category: Pathology Source Type: research
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Pathobiology 2017;84:351 –351 (Source: Pathobiology)
Source: Pathobiology - January 23, 2018 Category: Pathology Source Type: research
Acknowledgement to Reviewers
Pathobiology 2017;84:352 –352 (Source: Pathobiology)
Source: Pathobiology - January 23, 2018 Category: Pathology Source Type: research
Contents Vol. 84, 2017
Pathobiology 2017;84:I –IV (Source: Pathobiology)
Source: Pathobiology - January 23, 2018 Category: Pathology Source Type: research
The Impact of Anti-TNF Therapy on CD4+ and CD8+ Cell Subsets in Ankylosing Spondylitis
Conclusions: This study provides a comprehensive assessment of the impact of anti-TNF therapy on the T-cell repertoire in AS. Changes in T-cell phenotype seem to develop progressively during therapy, even in inactive disease, and reflect an ongoing effector T-cell differentiation and activation, along with the parallel compensatory increase in regulatory T cells.Pathobiology (Source: Pathobiology)
Source: Pathobiology - December 6, 2017 Category: Pathology Source Type: research
Next-Generation Sequencing in Diagnostics and Clinical Research
Pathobiology 2017;84:285 –287 (Source: Pathobiology)
Source: Pathobiology - November 30, 2017 Category: Pathology Source Type: research
APOBEC3A Expression in Penile Squamous Cell Carcinoma
Conclusion: Our results suggest that APOBEC3A expression is downregulated during progression towards invasiveness in HPV-negative penile SCC, but maintained in HPV-positive penile SCC. How high-risk HPV-infected tumor cells tolerate high APOBEC3A, which appears to exert tumor suppressive functions in HPV-negative penile SCCs, remains to be elucidated.Pathobiology (Source: Pathobiology)
Source: Pathobiology - November 22, 2017 Category: Pathology Source Type: research
Association of p53 Codon 72 Polymorphism with Breast Cancer in a Rwandese Population
Conclusion: These results suggest that p53 codon 72 polymorphism could not be assessed as a risk factor marker for predisposition to breast cancer in Rwanda. However, further studies using larger sample sizes are needed to provide more conclusive results and to investigate other genetic mutations affecting the activity of p53.Pathobiology (Source: Pathobiology)
Source: Pathobiology - November 1, 2017 Category: Pathology Source Type: research
Overexpression of the Transmembrane Protein IQGAP3 Is Associated with Poor Survival of Patients with Gastric Cancer
Conclusion: These results suggest that IQGAP3 plays an important role in gastric CSCs. The location of IQGAP3 on the cell membrane makes it a potential therapeutic target for GC.Pathobiology (Source: Pathobiology)
Source: Pathobiology - November 1, 2017 Category: Pathology Source Type: research
Next-Generation Sequencing in Diagnostic Pathology
Interrogation of tissue informs on patient management through delivery of a diagnosis together with associated clinically relevant data. The diagnostic pathologist will usually evaluate the morphological appearances of a tissue sample and, occasionally, the pattern of expression of a limited number of biomarkers. Recent developments in sequencing technology mean that DNA and RNA from tissue samples can now be interrogated in great detail. These new technologies, collectively known as next-generation sequencing (NGS), generate huge amounts of data which can be used to support patient management. In order to maximize the uti...
Source: Pathobiology - November 1, 2017 Category: Pathology Source Type: research
Tumor Heterogeneity in Pancreatic Adenocarcinoma
Pancreatic adenocarcinoma is one of the deadliest malignancies worldwide, mainly due to frequent diagnosis at an advanced stage and its strong chemoresistance. Tumor heterogeneity is evident at the histological level, both between tumors and even within a tumor. Recent high-throughput analyses have confirmed that intertumor heterogeneity is greater than intratumor heterogeneity that is mostly driven by successive catastrophic genetic events in the early stage and by epigenetic modifications in the metastatic stage. While this heterogeneity may complicate the search for a universal cure, these analyses have distinguished se...
Source: Pathobiology - October 25, 2017 Category: Pathology Source Type: research
