Proliferation Potential-Related Protein Promotes the Esophageal Cancer Cell Proliferation, Migration and Suppresses Apoptosis by Mediating the Expression of p53 and Interleukin-17
Conclusion: Our data suggest that PP-RP promotes esophageal cancer cell proliferation and migration, and suppresses apoptosis by mediating the expression of p53 and IL-17.Pathobiology (Source: Pathobiology)
Source: Pathobiology - September 17, 2018 Category: Pathology Source Type: research
Airway-Centered Pleuroparenchymal Fibroelastosis Associated with Non-Necrotizing Granulomas: A Rare New Entity
This report firstly describes a new variant or rare phenotype of PPFE with airway involvement, minimal pleuroparenchymal connections, and non-necrotizing granulomas.Pathobiology (Source: Pathobiology)
Source: Pathobiology - September 17, 2018 Category: Pathology Source Type: research
Congenital Pouch Colon: Role of Genetics or Environmental Influence?
Conclusion: Genetic study found that CPC could be a developmental disorder. These findings are important for further elucidating genetic causes of CPC pathogenesis.Pathobiology (Source: Pathobiology)
Source: Pathobiology - September 17, 2018 Category: Pathology Source Type: research
Egyptian Canopic Jars at the Crossroad of Medicine and Archaeology: Overview of 100 Years of Research and Future Scientific Expectations
In conclusion, this reassessment shows that canopic jars represent a highly underestimated source for histological, radiological and ancient DNA examination of Ancient Egyptian remains and should, thus, be more and more brought back into the focus of retrospective medical research.Pathobiology (Source: Pathobiology)
Source: Pathobiology - August 22, 2018 Category: Pathology Source Type: research
Egyptian Canopics Jars at the Crossroad of Medicine and Archaeology: Overview of 100 Years of Research and Future Scientific Expectations
In conclusion, this reassessment shows that canopic jars represent a highly underestimated source for histological, radiological and ancient DNA examination of Ancient Egyptian remains and should, thus, be more and more brought back into the focus of retrospective medical research.Pathobiology (Source: Pathobiology)
Source: Pathobiology - August 21, 2018 Category: Pathology Source Type: research
BAIBA Attenuates the Expression of Inflammatory Cytokines and Attachment Molecules and ER Stress in HUVECs and THP-1 Cells
Conclusion: BAIBA ameliorates LPS-induced atherosclerotic reactions via AMPK-mediated suppression of inflammation and ER stress.Pathobiology (Source: Pathobiology)
Source: Pathobiology - August 3, 2018 Category: Pathology Source Type: research
Myeloid Neoplasms with Germline Predisposition
The updated 2016 WHO classification of hematopoietic tumors has a new category: “myeloid neoplasms with germline predisposition.” These entities are rare, but are also currently underdiagnosed and underreported. Recognition is critical for appropriate clinical evaluation and therapy, with potential implications for the patient’s entire family. The WHO includes 3 categorie s of myeloid neoplasms with germline predisposition: neoplasms without preexisting conditions, neoplasms with a history of thrombocytopenia, and neoplasms with other organ dysfunction. Specialized molecular testing is frequently necessary to make th...
Source: Pathobiology - July 26, 2018 Category: Pathology Source Type: research
Myelodysplastic Syndrome Updated
This review highlights the main changes in the revised 2016 WHO Classification of Myeloid Neoplasms (published in 2017) that impact the diagnosis and management of patients with myelodysplastic syndrome (MDS). The revision was based on data accumulated since the 2008 WHO classification of MDS, much of which relates to new molecular genetic information about these neoplasms. The new information has led to some reorganization of the MDS disease categories, including a broadening of the subset of cases classified as MDS with ring sideroblasts, many of which have mutations in the spliceosome geneSF3B1. Other revisions have ref...
Source: Pathobiology - July 24, 2018 Category: Pathology Source Type: research
Challenges in Diagnosing Myelodysplastic Syndromes in the Era of Genetic Testing: Proceedings of the 13th Workshop of the European Bone Marrow Working Group
The 13th workshop of the European Bone Marrow Working Group in Utrecht, The Netherlands, was devoted to studying myelodysplastic syndromes (MDS) and their boundaries. The panel received 44 cases submitted to the 3 invited categories, which included: reactive cytopenias with dysplasia, idiopathic cytopenia of undetermined significance, clonal haematopoiesis of indeterminate potential, idiopathic dysplasia of uncertain significance and overt MDS. For this summary, we have selected 17 cases that highlight difficulties in separating true MDS from other causes of cytopenia and the intricate relationship between clonal haematopo...
Source: Pathobiology - July 6, 2018 Category: Pathology Source Type: research
The Diagnostic Work-Up of Hypereosinophilia
Hypereosinophilia (HE) is defined as a persistent elevated eosinophil count of ≥1.5 × 109/L. HE can be one of the dominant manifestations of a hematopoietic myeloid neoplasm or secondary/reactive to an underlying medical condition. If a cause of HE and its associated tissue/organ damage is not determined, the condition is considered to be idiopathic hypereosinophilic syndrome (HES). The work-up of HE can be challenging due to a broad range of causes of HE that can be either reactive or neoplastic. In recent years, with the advent of molecular genetic testing and the introduction of targeted therapy in the management of ...
Source: Pathobiology - June 29, 2018 Category: Pathology Source Type: research
Breast Cancer in a Lagos Facility: Implications for the Institution of a Cancer Screening Programme
Conclusion: The significant epidemiological and biological differences between breast cancer in Lagos and in western populations are important for the establishment of an effective breast cancer screening programme uniquely tailored for the Nigerian population.Pathobiology (Source: Pathobiology)
Source: Pathobiology - June 28, 2018 Category: Pathology Source Type: research
The 72Pro Variant of the Tumor Protein 53 Is Associated with an Increased Breast Cancer Risk in the Moroccan Population
Conclusion: Our results suggest that TP53 c.215G#x3e;C, p. (Arg72Pro) polymorphism may be considered as a genetic marker for predisposition to BC in Moroccan population.Pathobiology (Source: Pathobiology)
Source: Pathobiology - June 25, 2018 Category: Pathology Source Type: research
ICUS, IDUS, CHIP and CCUS: Diagnostic Criteria, Separation from MDS and Clinical Implications
Various myeloid neoplasms, including the myelodysplastic syndromes (MDS), bear a certain risk of progression to secondary acute myeloid leukemia (sAML). The evolution from low-risk to high-risk MDS and finally to sAML suggests that leukemogenesis is a multistep process. However, even before an overt neoplasm, such as an MDS, develops, “prediagnostic” clonal conditions may be identified. With the advent of large-scale genomic screens, such conditions may be detected quite frequently and early in apparently healthy individuals. Recent data suggest that these conditions increase with age and are indeed associated with an ...
Source: Pathobiology - June 8, 2018 Category: Pathology Source Type: research
Idiopathic Cytopenia of Uncertain Significance, Idiopathic Dysplasia of Unknown Significance, Clonal Hematopoiesis with Indeterminate Potential, and Clonal Cytopenia of Unknown Significance: Diagnostic Criteria, Separation from Myelodysplastic Syndromes, and Clinical Implications
Various myeloid neoplasms, including the myelodysplastic syndromes (MDS), bear a certain risk of progression to secondary acute myeloid leukemia (sAML). The evolution from low-risk to high-risk MDS and finally to sAML suggests that leukemogenesis is a multistep process. However, even before an overt neoplasm, such as an MDS, develops, “prediagnostic” clonal conditions may be identified. With the advent of large-scale genomic screens, such conditions may be detected quite frequently and early in apparently healthy individuals. Recent data suggest that these conditions increase with age and are indeed associated with an ...
Source: Pathobiology - June 1, 2018 Category: Pathology Source Type: research
Acral Lentiginous Melanoma Is Associated with Certain Poor Prognostic Histopathological Factors but May Not be Correlated with Nodal Involvement, Recurrence, and a Worse Survival
Conclusion: Although ALM is associated with some aggressive histopathological factors, it may not correlated with nodal involvement, recurrence, or poor survival.Pathobiology (Source: Pathobiology)
Source: Pathobiology - June 1, 2018 Category: Pathology Source Type: research
