LncRNA MAFG-AS1 Promotes the Progression of Bladder Cancer by Targeting the miR-143-3p/COX-2 Axis
Conclusion: The MAFG-AS1/miR-143-3p/COX-2 axis contributes to BLCA progression.Pathobiology (Source: Pathobiology)
Source: Pathobiology - November 25, 2020 Category: Pathology Source Type: research

Regulatory Single Nucleotide Polymorphism Increases < b > < i > TERT < /i > < /b > Promoter Activity in Thyroid Carcinoma Cells
Conclusion: We conclude that the presence of rs2853669 within theTERT promoter could be as significant as the C228T mutation in thyroid carcinoma.Pathobiology (Source: Pathobiology)
Source: Pathobiology - November 23, 2020 Category: Pathology Source Type: research

Microbiome and Cervical Cancer
Persistent infection with some types of mucosal human papillomavirus (HPV) is the etiological factor for the development of cervical cancer and its precursor lesions. Besides, several cofactors are known to play a role in cervical disease onset and progression either by favoring or by preventing HPV infection and persistence. The microbiome of a healthy female genital tract is characterized by the presence of 1 or few varieties of lactobacilli. However, high-throughput studies addressing the bacterial diversity and abundance in the female genital tract have shown that several factors, including hormonal levels, hygiene hab...
Source: Pathobiology - November 23, 2020 Category: Pathology Source Type: research

Oral Microbiota and Cancer Development
Oral microbiota are among the most diverse in the human body. More than 700 species have been identified in the mouth, and new sequencing methods are allowing us to discover even more species. The anatomy of the oral cavity is different from that of other body sites. The oral cavity has mucosal surfaces (the tongue, the buccal mucosa, the gingiva, and the palate), hard tissues (the teeth), and exocrine gland tissue (major and minor salivary glands), all of which present unique features for microbiota composition. The connection between oral microbiota and diseases of the human body has been under intensive research in the ...
Source: Pathobiology - November 11, 2020 Category: Pathology Source Type: research

Retrospective Post-mortem SARS-CoV-2 RT-PCR of Autopsies with COVID-19-Suggestive Pathology Supports the Absence of Lethal Community Spread in Basel, Switzerland, before February 2020
Conclusion: Our data suggest the absence of early lethal community spread of COVID-19 in Basel before its initial reported emergence in Switzerland in March 2020.Pathobiology (Source: Pathobiology)
Source: Pathobiology - November 6, 2020 Category: Pathology Source Type: research

Gastric Cancer in < b > < i > BRCA1 < /i > < /b > Germline Mutation Carriers: Results of Endoscopic Screening and Molecular Analysis of Tumor Tissues
Conclusion: Taken together, these data justify further studies on the relationships between theBRCA1/2 and gastric cancer.Pathobiology (Source: Pathobiology)
Source: Pathobiology - November 6, 2020 Category: Pathology Source Type: research

A Covid-19 Patient with Complement-Mediated Coagulopathy and Severe Thrombosis
We report a patient with severe Covid-19-associated coagulopathy and type 2 diabetes mellitus who tested positive for antiphospholipid antibodies (aPL). Analysis of skin specimens suggested direct SARS-CoV-2 viral-induced and complement-mediated vascular injury and thrombosis, consistent with prior reports. Serial aPL testing demonstrated high levels of anticardiolipin antibodies (aCL) that declined to insignificant levels over a period of 5 weeks. SARS-CoV-2 RNA was detected in nasopharyngeal swab specimens on serial assays performed over the same 5-week period, though it was not detected thereafter. We hypothesize that S...
Source: Pathobiology - November 2, 2020 Category: Pathology Source Type: research

The Liver in COVID-19-Related Death: Protagonist or Innocent Bystander?
Conclusion: The main histological changes can be explained by the hypoxic status as a result of severe hypoxemic pneumonia leading to death. Drug toxicity may also play a role in certain cases. Other histological changes may be explained by previous hepatic conditions or underlying hepatic diseases. We concluded that COVID-19 infection was not associated with a specific histopathological pattern of the liver.Pathobiology (Source: Pathobiology)
Source: Pathobiology - October 27, 2020 Category: Pathology Source Type: research

In situ Evidence of Collagen V and Interleukin-6/Interleukin-17 Activation in Vascular Remodeling of Experimental Pulmonary Hypertension
In conclusion, our findings indicate in situ evidence of Col V and IL-6/IL-17 activation in vascular remodeling and suggest that increase of Col V may yield potential therapeutic targets for treating pa tients with PAH.Pathobiology (Source: Pathobiology)
Source: Pathobiology - October 23, 2020 Category: Pathology Source Type: research

The Impact of COVID-19 Disease on Platelets and Coagulation
Coronavirus disease 2019 (COVID-19) causes a spectrum of disease; some patients develop a severe proinflammatory state which can be associated with a unique coagulopathy and procoagulant endothelial phenotype. Initially, COVID-19 infection produces a prominent elevation of fibrinogen and D-dimer/fibrin(ogen) degradation products. This is associated with systemic hypercoagulability and frequent venous thromboembolic events. The degree of D-dimer elevation positively correlates with mortality in COVID-19 patients. COVID-19 also leads to arterial thrombotic events (including strokes and ischemic limbs) as well as microvascula...
Source: Pathobiology - October 13, 2020 Category: Pathology Source Type: research

Application of “Tissueoid Cell Culture System” Using a Silicate Fiber Scaffold for Cancer Research
Conclusion: Because the morphology of cancer cells cultured in this 3D culture system is similar to that in living organisms, we called the system a “tissueoid cell culture system.” Coating with collagen IV enables the modification of cell-matrix interactions as well as recapitulation of the in vivo microenvironment.Pathobiology (Source: Pathobiology)
Source: Pathobiology - September 23, 2020 Category: Pathology Source Type: research

Placental Pathology Findings during and after SARS-CoV-2 Infection: Features of Villitis and Malperfusion
We present a series of five placentas of SARS coronavirus 2 (SARS-CoV-2)-positive women who had been diagnosed with mild symptoms of COVID-19 or had been asymptomatic before birth. We provide a detailed histopathologic description of morphological changes accompanied by an analysis of presence of SARS-CoV-2 in the placental tissue. All placentas were term deliveries (40th and 41st gestational weeks). One SARS-CoV-2-positive patient presented with cough and dyspnoea. This placenta showed prominent lymphohistiocytic villitis and intervillositis and signs of maternal and foetal malperfusion. Viral RNA was present in both plac...
Source: Pathobiology - September 18, 2020 Category: Pathology Source Type: research

Autopsy Findings in 32 Patients with COVID-19: A Single-Institution Experience
Conclusion: This series of autopsies from patients with COVID-19 confirms the observation that the majority of severely affected patients have significant pulmonary pathology. However, many patients also have widespread microscopic thromboses, as well as characteristic findings in the liver and lymph nodes.Pathobiology (Source: Pathobiology)
Source: Pathobiology - September 17, 2020 Category: Pathology Source Type: research

Long Noncoding RNA HOTAIR Promotes Epithelial-Mesenchymal Transition and Is a Suitable Target to Inhibit Peritoneal Dissemination in Human Scirrhous Gastric Cancers
Conclusion: An EMT-associated pathway (the HOTAIR-miR-217-ZEB1 axis) appears to inhibit peritoneal dissemination and could lead to a novel therapeutic strategy against scirrhous gastric cancer in humans.Pathobiology (Source: Pathobiology)
Source: Pathobiology - September 16, 2020 Category: Pathology Source Type: research

High Activation of the AKT Pathway in Human Multicystic Renal Dysplasia
This study demonstrates the essential and specific role of the PI3K-AKT-mTOR pathway in the formation of cysts in multicystic renal dysplasia.Pathobiology (Source: Pathobiology)
Source: Pathobiology - September 14, 2020 Category: Pathology Source Type: research