The Application of Extended Reality in Treating Children with Autism Spectrum Disorder
AbstractAutism Spectrum Disorder (ASD) is a common neurodevelopmental disorder in children, characterized by social interaction, communication difficulties, and repetitive and stereotyped behaviors. Existing intervention methods have limitations, such as requiring long treatment periods and needing to be more convenient to implement. Extended Reality (XR) technology offers a virtual environment to enhance children's social, communication, and self-regulation skills. This paper compares XR theoretical models, application examples, and intervention effects. The study reveals that XR intervention therapy is mainly based on co...
Source: Neuroscience Bulletin - March 18, 2024 Category: Neuroscience Source Type: research
Chimeric Monkey Born Alive with a High Contribution of Donor Cells
(Source: Neuroscience Bulletin)
Source: Neuroscience Bulletin - March 16, 2024 Category: Neuroscience Source Type: research
GABAergic Interneuron Cell Therapy for Drug-Resistant Epilepsy
(Source: Neuroscience Bulletin)
Source: Neuroscience Bulletin - March 16, 2024 Category: Neuroscience Source Type: research
SMART (Splitting-Merging Assisted Reliable) Independent Component Analysis for Extracting Accurate Brain Functional Networks
AbstractFunctional networks (FNs) hold significant promise in understanding brain function. Independent component analysis (ICA) has been applied in estimating FNs from functional magnetic resonance imaging (fMRI). However, determining an optimal model order for ICA remains challenging, leading to criticism about the reliability of FN estimation. Here, we propose a SMART (splitting-merging assisted reliable) ICA method that automatically extracts reliable FNs by clustering independent components (ICs) obtained from multi-model-order ICA using a simplified graph while providing linkages among FNs deduced from different-mode...
Source: Neuroscience Bulletin - March 15, 2024 Category: Neuroscience Source Type: research
Positron Emission Tomography Imaging of Synaptic Dysfunction in Parkinson ’s Disease
AbstractParkinson ’s disease (PD) is one of the most common neurodegenerative diseases with a complex pathogenesis. Aggregations formed by abnormal deposition of alpha-synuclein (αSyn) lead to synapse dysfunction of the dopamine and non-dopamine systems. The loss of dopaminergic neurons and concomitant alterations in non-dopaminergic function in PD constitute its primary pathological manifestation. Positron emission tomography (PET), as a representative molecular imaging technique, enables the non-invasive visualization, characterization, and quantification of biological processes at cellular and molecular l evels. Imag...
Source: Neuroscience Bulletin - March 14, 2024 Category: Neuroscience Source Type: research
Emerging Human Pluripotent Stem Cell-Based Human –Animal Brain Chimeras for Advancing Disease Modeling and Cell Therapy for Neurological Disorders
AbstractHuman pluripotent stem cell (hPSC) models provide unprecedented opportunities to study human neurological disorders by recapitulating human-specific disease mechanisms. In particular, hPSC-based human –animal brain chimeras enable the study of human cell pathophysiologyin vivo. In chimeric brains, human neural and immune cells can maintain human-specific features, undergo maturation, and functionally integrate into host brains, allowing scientists to study how human cells impact neural circuits and animal behaviors. The emerging human–animal brain chimeras hold promise for modeling human brain cells and their...
Source: Neuroscience Bulletin - March 11, 2024 Category: Neuroscience Source Type: research
Face-Specific Activity in the Ventral Stream Visual Cortex Linked to Conscious Face Perception
AbstractWhen presented with visual stimuli of face images, the ventral stream visual cortex of the human brain exhibits face-specific activity that is modulated by the physical properties of the input images. However, it is still unclear whether this activity relates to conscious face perception. We explored this issue by using the human intracranial electroencephalography technique. Our results showed that face-specific activity in the ventral stream visual cortex was significantly higher when the subjects subjectively saw faces than when they did not, even when face stimuli were presented in both conditions. In addition,...
Source: Neuroscience Bulletin - March 8, 2024 Category: Neuroscience Source Type: research
Dopaminergic Remodeling During a Critical Developmental Window: Linking Drug Use to Adult Aggression
(Source: Neuroscience Bulletin)
Source: Neuroscience Bulletin - March 8, 2024 Category: Neuroscience Source Type: research
mTORC2: The “Ace in the Hole” for a Broader Control of Epileptic Seizures?
(Source: Neuroscience Bulletin)
Source: Neuroscience Bulletin - March 7, 2024 Category: Neuroscience Source Type: research
Interactions Between Extracellular Vesicles and Autophagy in Neuroimmune Disorders
AbstractNeuroimmune disorders, such as multiple sclerosis, neuromyelitis optica spectrum disorder, myasthenia gravis, and Guillain –Barré syndrome, are characterized by the dysfunction of both the immune system and the nervous system. Increasing evidence suggests that extracellular vesicles and autophagy are closely associated with the pathogenesis of these disorders. In this review, we summarize the current understanding of the interactions between extracellular vesicles and autophagy in neuroimmune disorders and discuss their potential diagnostic and therapeutic applications. Here we highlight the need for further res...
Source: Neuroscience Bulletin - February 29, 2024 Category: Neuroscience Source Type: research
LH-Nts Neurons Regulate VTA Calcium Dynamics Via Releasing GABA and Nts
(Source: Neuroscience Bulletin)
Source: Neuroscience Bulletin - February 28, 2024 Category: Neuroscience Source Type: research
Neural Circuitry Involving Substance P in Male Sexual Behavior
(Source: Neuroscience Bulletin)
Source: Neuroscience Bulletin - February 20, 2024 Category: Neuroscience Source Type: research
Tetherless Optical Neuromodulation: Wavelength from Orange-red to Mid-infrared
AbstractOptogenetics, a technique that employs light for neuromodulation, has revolutionized the study of neural mechanisms and the treatment of neurological disorders due to its high spatiotemporal resolution and cell-type specificity. However, visible light, particularly blue and green light, commonly used in conventional optogenetics, has limited penetration in biological tissue. This limitation necessitates the implantation of optical fibers for light delivery, especially in deep brain regions, leading to tissue damage and experimental constraints. To overcome these challenges, the use of orange-red and infrared light ...
Source: Neuroscience Bulletin - February 19, 2024 Category: Neuroscience Source Type: research
Nanoscale Reorganization of Glutamate Receptors Underlies Synaptic Plasticity and Pathology
(Source: Neuroscience Bulletin)
Source: Neuroscience Bulletin - February 19, 2024 Category: Neuroscience Source Type: research
Functional Changes in Astrocytes Lead to Cognitive Deficits After Social Deprivation
(Source: Neuroscience Bulletin)
Source: Neuroscience Bulletin - February 14, 2024 Category: Neuroscience Source Type: research
