Nociceptors and Macrophages in Bacterial Meningitis: Partners in Crime?
(Source: Neuroscience Bulletin)
Source: Neuroscience Bulletin - November 14, 2023 Category: Neuroscience Source Type: research
Prefrontocortical Astrocytes Regulate Dominance Hierarchy in Male Mice
(Source: Neuroscience Bulletin)
Source: Neuroscience Bulletin - November 5, 2023 Category: Neuroscience Source Type: research
The Neural Mechanism of Knowledge Assembly in the Human Brain Inspires Artificial Intelligence Algorithm
(Source: Neuroscience Bulletin)
Source: Neuroscience Bulletin - November 4, 2023 Category: Neuroscience Source Type: research
A Spleen Tyrosine Kinase ’s Sky in Neuronal Degeneration
(Source: Neuroscience Bulletin)
Source: Neuroscience Bulletin - November 3, 2023 Category: Neuroscience Source Type: research
Disease Burden and Costs Associated with Multiple Sclerosis in China: A Cross-sectional Analysis of Nationwide Survey Data
(Source: Neuroscience Bulletin)
Source: Neuroscience Bulletin - November 2, 2023 Category: Neuroscience Source Type: research
Developmental Patterns and Gender Differences of Vocal Production in Marmoset Monkeys
(Source: Neuroscience Bulletin)
Source: Neuroscience Bulletin - November 1, 2023 Category: Neuroscience Source Type: research
Genomic Mosaicism of the Brain: Origin, Impact, and Utility
AbstractGenomic mosaicism describes the phenomenon where some but not all cells within a tissue harbor unique genetic mutations. Traditionally, research focused on the impact of genomic mosaicism on clinical phenotype —motivated by its involvement in cancers and overgrowth syndromes. More recently, we increasingly shifted towards the plethora of neutral mosaic variants that can act as recorders of cellular lineage and environmental exposures. Here, we summarize the current state of the field of genomic mosaicis m research with a special emphasis on our current understanding of this phenomenon in brain development and hom...
Source: Neuroscience Bulletin - October 29, 2023 Category: Neuroscience Source Type: research
Development of SV2A Ligands for Epilepsy Treatment: A Review of Levetiracetam, Brivaracetam, and Padsevonil
AbstractEpilepsy is a common neurological disorder that is primarily treated with antiseizure medications (ASMs). Although dozens of ASMs are available in the clinic, approximately 30% of epileptic patients have medically refractory seizures; other limitations in most traditional ASMs include poor tolerability and drug-drug interactions. Therefore, there is an urgent need to develop alternative ASMs. Levetiracetam (LEV) is a first-line ASM that is well tolerated, has promising efficacy, and has little drug-drug interaction. Although it is widely accepted that LEV acts through a unique therapeutic target synaptic vesicle pr...
Source: Neuroscience Bulletin - October 28, 2023 Category: Neuroscience Source Type: research
Effects of Thirty Days Isolation on Attention Networks: A Behavioral and Event-related Potential Study
(Source: Neuroscience Bulletin)
Source: Neuroscience Bulletin - October 27, 2023 Category: Neuroscience Source Type: research
Inflammatory Factor IL1 α Induces Aberrant Astrocyte Proliferation in Spinal Cord Injury Through the Grin2c/Ca2+/CaMK2b Pathway
AbstractSpinal cord injury (SCI) is one of the most devastating traumas, and the aberrant proliferation of astrocytes usually causes neurological deficits. However, the mechanism underlying astrocyte over-proliferation after SCI is unclear. Grin2c (glutamate ionotropic receptor type 2c) plays an essential role in cell proliferation. Our bioinformatic analysis indicated that Grin2c and Ca2+ transport functions were inhibited in astrocytes after SCI. Suppression of Grin2c stimulated astrocyte proliferation by inhibiting the Ca2+/calmodulin-dependent protein kinase 2b (CaMK2b) pathwayin vitro. By screening different inflammat...
Source: Neuroscience Bulletin - October 21, 2023 Category: Neuroscience Source Type: research
The Multiple Roles of Autophagy in Neural Function and Diseases
AbstractAutophagy involves the sequestration and delivery of cytoplasmic materials to lysosomes, where proteins, lipids, and organelles are degraded and recycled. According to the way the cytoplasmic components are engulfed, autophagy can be divided into macroautophagy, microautophagy, and chaperone-mediated autophagy. Recently, many studies have found that autophagy plays an important role in neurological diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, neuronal excitotoxicity, and cerebral ischemia. Autophagy maintains cell homeostasis in the nervous system via degradation of misfolded ...
Source: Neuroscience Bulletin - October 19, 2023 Category: Neuroscience Source Type: research
Theta Oscillations Support Prefrontal-hippocampal Interactions in Sequential Working Memory
This study suggests that theta oscillations may support DLPFC-hippocampal interactions in the online processing of sequential information. (Source: Neuroscience Bulletin)
Source: Neuroscience Bulletin - October 17, 2023 Category: Neuroscience Source Type: research
Neural Stem Cell Competition
(Source: Neuroscience Bulletin)
Source: Neuroscience Bulletin - October 17, 2023 Category: Neuroscience Source Type: research
Temporal-spatial Generation of Astrocytes in the Developing Diencephalon
AbstractAstrocytes are the largest glial population in the mammalian brain. However, we have a minimal understanding of astrocyte development, especially fate specification in different regions of the brain. Through lineage tracing of the progenitors of the third ventricle (3V) wallvia in-utero electroporation in the embryonic mouse brain, we show the fate specification and migration pattern of astrocytes derived from radial glia along the 3V wall. Unexpectedly, radial glia located in different regions along the 3V wall of the diencephalon produce distinct cell types: radial glia in the upper region produce astrocytes and ...
Source: Neuroscience Bulletin - October 16, 2023 Category: Neuroscience Source Type: research
Propofol Brings on the Light for Depression Therapy
(Source: Neuroscience Bulletin)
Source: Neuroscience Bulletin - October 10, 2023 Category: Neuroscience Source Type: research
