TREMble Before TREM2: The Mighty Microglial Receptor Conferring Neuroprotective Properties in TDP-43 Mediated Neurodegeneration
(Source: Neuroscience Bulletin)
Source: Neuroscience Bulletin - August 17, 2022 Category: Neuroscience Source Type: research
Potential Effects of the COVID-19 Pandemic on the Developing Brain
(Source: Neuroscience Bulletin)
Source: Neuroscience Bulletin - August 17, 2022 Category: Neuroscience Source Type: research
Chemogenetic and Optogenetic Manipulations of Microglia in Chronic Pain
AbstractChronic pain relief remains an unmet medical need. Current research points to a substantial contribution of glia-neuron interaction in its pathogenesis. Particularly, microglia play a crucial role in the development of chronic pain. To better understand the microglial contribution to chronic pain, specific regional and temporal manipulations of microglia are necessary. Recently, two new approaches have emerged that meet these demands. Chemogenetic tools allow the expression of designer receptors exclusively activated by designer drugs (DREADDs) specifically in microglia. Similarly, optogenetic tools allow for micro...
Source: Neuroscience Bulletin - August 17, 2022 Category: Neuroscience Source Type: research
Elevated Levels of Naturally-Occurring Autoantibodies Against the Extracellular Domain of p75NTR Aggravate the Pathology of Alzheimer ’s Disease
This study was designed to investigate the presence and alterations of naturally-occurring autoantibodies a gainst p75ECD (p75ECD-NAbs) in AD patients and their effects on AD pathology. We found that the cerebrospinal fluid (CSF) level of p75ECD-NAbs was increased in AD, and negatively associated with the CSF levels of p75ECD. Transgenic AD mice actively immunized with p75ECD showed a lower level of p75EC D and more severe AD pathology in the brain, as well as worse cognitive functions than the control groups, which were immunized with Re-p75ECD (the reverse sequence of p75ECD) and phosphate-buffered saline, respectively. ...
Source: Neuroscience Bulletin - August 16, 2022 Category: Neuroscience Source Type: research
PROK2 –PROKR2 Signaling: New Contributor to Pleasant Touch
(Source: Neuroscience Bulletin)
Source: Neuroscience Bulletin - August 12, 2022 Category: Neuroscience Source Type: research
Volumetric Imaging of Neural Activity by Light Field Microscopy
AbstractRecording the highly diverse and dynamic activities in large populations of neurons in behaving animals is crucial for a better understanding of how the brain works. To meet this challenge, extensive efforts have been devoted to developing functional fluorescent indicators and optical imaging techniques to optically monitor neural activity. Indeed, optical imaging potentially has extremely high throughput due to its non-invasive access to large brain regions and capability to sample neurons at high density, but the readout speed, such as the scanning speed in two-photon scanning microscopy, is often limited by vari...
Source: Neuroscience Bulletin - August 8, 2022 Category: Neuroscience Source Type: research
Brain-Computer Interfaces in Disorders of Consciousness
(Source: Neuroscience Bulletin)
Source: Neuroscience Bulletin - August 8, 2022 Category: Neuroscience Source Type: research
Non-hallucinogenic Psychedelic Analog Design: A Promising Direction for Depression Treatment
(Source: Neuroscience Bulletin)
Source: Neuroscience Bulletin - August 5, 2022 Category: Neuroscience Source Type: research
Specialized Microglia Resolve Neuropathic Pain in the Spinal Cord
(Source: Neuroscience Bulletin)
Source: Neuroscience Bulletin - August 3, 2022 Category: Neuroscience Source Type: research
Neural Mechanism Underlying Task-Specific Enhancement of Motor Learning by Concurrent Transcranial Direct Current Stimulation
AbstractThe optimal protocol for neuromodulation by transcranial direct current stimulation (tDCS) remains unclear. Using the rotarod paradigm, we found that mouse motor learning was enhanced by anodal tDCS (3.2 mA/cm2) during but not before or after the performance of a task. Dual-task experiments showed that motor learning enhancement was specific to the task accompanied by anodal tDCS. Studies using a mouse model of stroke induced by middle cerebral artery occlusion showed that concurrent anodal tDCS restored motor learning capability in a task-specific manner. Transcranialin vivo Ca2+ imaging further showed that anodal...
Source: Neuroscience Bulletin - July 30, 2022 Category: Neuroscience Source Type: research
UNC13A Gene Brings New Hope for ALS Disease-Modifying Drugs
(Source: Neuroscience Bulletin)
Source: Neuroscience Bulletin - July 30, 2022 Category: Neuroscience Source Type: research
Correction: Cognitive Impairment in Idiopathic Normal Pressure Hydrocephalus
(Source: Neuroscience Bulletin)
Source: Neuroscience Bulletin - July 25, 2022 Category: Neuroscience Source Type: research
Dopamine Control of REM Sleep and Cataplexy
(Source: Neuroscience Bulletin)
Source: Neuroscience Bulletin - July 21, 2022 Category: Neuroscience Source Type: research
Correction: Inhibition of HIPK3 by AST487 Ameliorates Mutant HTT-Induced Neurotoxicity and Apoptosis via Enhanced Autophagy
(Source: Neuroscience Bulletin)
Source: Neuroscience Bulletin - July 21, 2022 Category: Neuroscience Source Type: research
Reading-related Brain Function Restored to Normal After Articulation Training in Patients with Cleft Lip and Palate: An fMRI Study
AbstractCleft lip and/or palate (CLP) are the most common craniofacial malformations in humans. Speech problems often persist even after cleft repair, such that follow-up articulation training is usually required. However, the neural mechanism behind effective articulation training remains largely unknown. We used fMRI to investigate the differences in brain activation, functional connectivity, and effective connectivity across CLP patients with and without articulation training and matched normal participants. We found that training promoted task-related brain activation among the articulation-related brain networks, as w...
Source: Neuroscience Bulletin - July 18, 2022 Category: Neuroscience Source Type: research
