Erratum
Neurodegener Dis 2018;18:254 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - October 24, 2018 Category: Neurology Source Type: research
Cortical Thinning Associated with Age and CSF Biomarkers in Early Parkinson ’s Disease Is Modified by the SNCA rs356181 Polymorphism
The role of cerebrospinal fluid (CSF) biomarkers such as CSF α-synuclein and CSF tau in predicting cognitive decline in Parkinson’s disease (PD) continues to be inconsistent. Here, using a cohort of de novo PD patients with preserved cognition from the Parkinson’s Progression Markers Initiative (PPMI), we show that the SNCA rs356181 single nucleotide pol ymorphism (SNP) modulates the effect of these CSF biomarkers on cortical thinning. Depending on this SNP’s genotype, cortical atrophy was associated with either higher or lower CSF biomarker levels. Additionally, this SNP modified age-related atrophy. Importantly, t...
Source: Neurodegenerative Diseases - October 18, 2018 Category: Neurology Source Type: research
C9orf72 Repeat Expansion Frequency among Patients with Huntington Disease Genetic Testing
Conclusion: These findings suggest thatC9orf72 repeat expansion does not coexist withHTT repeat expansion and thatC9orf72 repeat expansion testing is unnecessary for patients with HD. In addition,C9orf72 evaluation may be considered for individuals negative for HD genetic testing. Similar to in previous studies, methylation ofC9orf72 repeat expansion was limited to large expansions.Neurodegener Dis 2018;18:239 –253 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - October 18, 2018 Category: Neurology Source Type: research
Critical Review of Complementary and Alternative Medicine Use in Amyotrophic Lateral Sclerosis: Prevalence and Users ’ Profile, Decision-Making, Information Seeking, and Disclosure in the Face of a Lack of Efficacy
Conclusion: A proportion of ALS patients report utilizing CAM concurrently with conventional treatments. Such use, set amidst a dearth of evidence for the efficacy of CAM in ALS, poses potential direct and indirect risks to patient care, and medical providers should be mindful of and enquire about CAM use when treating ALS patients.Neurodegener Dis 2018;18:225 –232 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - October 5, 2018 Category: Neurology Source Type: research
Prevalence of Apolipoprotein E Polymorphisms in Alzheimer ’s Disease, Mild Cognitive Impairment, and Healthy Elderly: A Northern Greece Study
Conclusion: In Greece, APOE ε4 presence is related to an increased risk for AD in a dose-related manner. Contrary to long-standing views, men and women with the APOE ε4 genotype have nearly the same odds of developing MCI and AD.Neurodegener Dis 2018;18:216 –224 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - September 11, 2018 Category: Neurology Source Type: research
Evaluation of Chitotriosidase and CC-Chemokine Ligand 18 as Biomarkers of Microglia Activation in Amyotrophic Lateral Sclerosis
Conclusions: High ChT activity in CSF of patients with ALS may reflect microglia activation and could be a potential biomarker of the disease. We did not find any significant difference regarding CCL-18, another specific marker of microglia activation that is related with M2-like microglia phenotype. Deepening the understanding of the activation state of microglia (M1 and M2) may contribute to the knowledge about the specific role of neuroinflammation in ALS and future therapeutic strategies.Neurodegener Dis 2018;18:208 –215 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - August 22, 2018 Category: Neurology Source Type: research
Relationship between Liver Pathology and Disease Progression in a Murine Model of Amyotrophic Lateral Sclerosis
Conclusions: Taken together, these findings suggest that liver dysfunction in hSOD1G93A transgenic mice is mediated by increased inflammation and oxidative stress as well as the upregulation of fibrosis-related proteins.Neurodegener Dis 2018;18:200 –207 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - August 21, 2018 Category: Neurology Source Type: research
Estimating the Evolution of Disease in the Parkinson ’s Progression Markers Initiative
In this study, we apply a latent time joint mixed-effects model to study biomarker progression and disease dynamics in the Parkinson’s Progression Markers Initiative (PPMI) and examine which markers might be most informative in the earliest phases of disease. The results reveal that, even though diagnostic category was not included in the model, it seems to accurately reflect the temporal ordering of the disease state consistent with diagnosis categorization at baseline. In addit ion, results indicated that the specific binding ratio on striatum and the total Unified Parkinson’s Disease Rating Scale (UPDRS) show high d...
Source: Neurodegenerative Diseases - August 8, 2018 Category: Neurology Source Type: research
Gene Co-Expression Network Analysis Implicates microRNA Processing in Parkinson ’s Disease Pathogenesis
Conclusion: These results suggest that microRNA processing and function may play a role in the pathogenesis of PD, and thus may represent a useful target for future drug development.Neurodegener Dis 2018;18:191 –199 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - August 8, 2018 Category: Neurology Source Type: research
Erratum
Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - July 24, 2018 Category: Neurology Source Type: research
Interferon Lambda Family along with HTLV-1 Proviral Load, Tax, and HBZ Implicated in the Pathogenesis of Myelopathy/Tropical Spastic Paraparesis
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic neuroinflammatory disease related to human T lymphotropic virus type 1 (HTLV-1) infection. Interferon type III (IFN- λ), which includes IL28, IL29, and IL28R, and affects the outcome of viral infections, might be complicated in the progression of HAM/TSP. Here, we investigated the host-virus interactions in the manifestation of HAM/TSP, using IL28B, IL29, IL28R, HTLV-1 Tax, HTLV-1 basic leucine zipper factor (HBZ ), and proviral load (PVL). The study groups consisted of 20 patients with HAM/TSP, 20 asymptomatic HTLV-1 carriers (ACs), and 20 h...
Source: Neurodegenerative Diseases - July 10, 2018 Category: Neurology Source Type: research
Novel < b > < i > ABCD1 < /i > < /b > Gene Mutation in Adrenomyeloneuropathy with Hypoplasia and Agenesis of the Corpus Callosum
Conclusion: In addition to the typical symptoms such as spastic myelopathy, cognitive impairment, mixed neuropathy, and alopecia, AMN patients can also display hypoplasia and agenesis of the CC, which was not described in the other AMN patients reported before.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - July 2, 2018 Category: Neurology Source Type: research
Feasibility of Smartphone-Based Testing of Interference in Parkinson ’s Disease
Conclusions: We established that despite motor impairment, the novel approach of using smartphone technology to test interference in PD patients is feasible.Neurodegener Dis 2018;18:133 –142 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - June 25, 2018 Category: Neurology Source Type: research
Distinctive Olfactory Pattern in Parkinson ’s Disease and Non-Neurodegenerative Causes of Hyposmia
Conclusions: A differential pattern of hyposmia was observed in PD patients compared to other non-neurodegenerative aetiologies. Further studies with larger samples should replicate our results.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - June 25, 2018 Category: Neurology Source Type: research
Neurofilament Subunit L Levels in the Cerebrospinal Fluid and Serum of Patients with Amyotrophic Lateral Sclerosis
Conclusions: NF-L levels increased in CSF and serum of patients with ALS. NF-L may thus be a neurodegenerative biomarker for predicting ALS severity and progression, and the survival of patients with this disease.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - June 13, 2018 Category: Neurology Source Type: research
