Alzheimer's and Parkinson's Diseases: Mechanisms, Clinical Strategies, and Promising Treatments of Neurodegenerative Diseases 11th International Conference AD/PDTM Florence, Italy, March 6-10, 2013: Abstracts
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Neurodegener Dis 2013;11:(suppl 1):1 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - September 2, 2015 Category: Neurology Source Type: research
Breakdown of Sensorimotor Network Communication in Leukoaraiosis
Conclusions: These results suggest that LA impairs sensorimotor integration by interfering with the communication or coordination of these aforementioned regions related to the SMN.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - August 20, 2015 Category: Neurology Source Type: research
The Big Bluff of Amyotrophic Lateral Sclerosis Diagnosis: The Role of Neurodegenerative Disease Mimics
Neurodegenerative diseases include a significant number of pathologies affecting the nervous system. Generally, the primary cause of each disease is specific; however, recently, it was shown that they may be correlated at molecular level. This aspect, together with the exhibition of similar symptoms, renders the diagnosis of these disorders difficult. Amyotrophic lateral sclerosis is one of these pathologies. Herein, we report several cases of amyotrophic lateral sclerosis misdiagnosed as a consequence of features that are common to several neurodegenerative diseases, such as Parkinson's, Huntington's and Alzheimer's disea...
Source: Neurodegenerative Diseases - July 29, 2015 Category: Neurology Source Type: research
Imaging in Glucocerebrosidase-Associated Parkinsonism: Current Status and Implications for Pathophysiology
Conclusions: Further imaging studies conducted in a broader population of early GBA-PD are warranted to characterize the disease and elucidate the pathophysiological mechanisms underlying GBA-PD and to understand GBA implications in iPD.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - July 28, 2015 Category: Neurology Source Type: research
Erratum
Neurodegener Dis 2015;15:258 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - July 25, 2015 Category: Neurology Source Type: research
Cognitive Impairment and Its Structural Correlates in the Parkinsonian Subtype of Multiple System Atrophy
Conclusions: Our data demonstrate that cortical and cerebellar atrophy and striatal degeneration are associated with cognitive impairment in patients with MSA-P.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - July 21, 2015 Category: Neurology Source Type: research
An Assessment of Possible Neuropathology and Clinical Relationships in 46 Sporadic Amyotrophic Lateral Sclerosis Patient Autopsies
Conclusion: Our findings support the hypothesis that ALS and its variants could comprise a larger neuropathological continuum.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - July 17, 2015 Category: Neurology Source Type: research
Application of the Bead-Based Technique in Neurodegeneration: A Literature Review
Conclusion: Review of literature data shows that the combined analysis of classical CSF biomarkers with novel biomarkers might increase the specificity and sensitivity of performed tests. However, we concluded that the replacement of conventional ELISA with the bead-based technique requires new reference intervals for Aβ1-42, T-tau and P-tau concentrations.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - July 17, 2015 Category: Neurology Source Type: research
Plasma Cholinesterase Activity in Alzheimer's Disease
Cholinesterase inhibitors (ChEIs) are not allowed to be prescribed in combination, which means that we need to select 1 of 3 ChEIs for use in a patient with Alzheimer's disease (AD). However, there is no quantitative analysis on the differences between these agents. In this article, we propose that plasma cholinesterase activity (pChE) could be used as the standard for differentiating between rivastigmine (Riv) and donepezil (Don) in the management of AD. To date, we have treated 6 patients with Riv 18 mg and 5 patients with Don 5 mg. The pChE is related to low-grade inflammation associated with AD, diabetes mellitus and l...
Source: Neurodegenerative Diseases - July 8, 2015 Category: Neurology Source Type: research
Author and Subject Index Vol. 15, No. 3, 2105
Neurodegener Dis 2015;15:191 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - July 8, 2015 Category: Neurology Source Type: research
Parkin Is Dispensable for Mitochondrial Function, but Its Ubiquitin Ligase Activity Is Critical for Macroautophagy and Neurotransmitters: Therapeutic Potential beyond Parkinson's Disease
Parkin biology has emerged as an exciting area of pharmaceutical development for several human diseases, including cancer and neurodegeneration. Parkin's role is multifaceted in human health and disease and its function affecting major cellular quality control mechanisms, including the ubiquitin-proteasome and autophagy-lysosome systems, is critical in the maintenance of cellular homeostasis. Loss of Parkin function due to aging, protein instability and gene mutations is manifest in a number of human diseases, contributing to the validation of this protein as a therapeutic target. Parkin activation to mobilize cellular qua...
Source: Neurodegenerative Diseases - July 4, 2015 Category: Neurology Source Type: research
Does Anticholinergic Activity Affect Neuropathology Implication of Neuroinflammation in Alzheimer's Disease
One characteristic neuropathological feature of Alzheimer's disease (AD) is profound neuronal loss in the nucleus basalis of Meynert, the major source of cholinergic innervation of the cerebral cortex. Clinically, anticholinergic activity causes a decline in cognitive function and increases the risk of dementia, thus possibly enhancing AD pathologies and neurodegeneration. Until now there has been insufficient human neuropathological data to support this conclusion. Experimental studies using a tauopathy mouse model demonstrated anticholinergics enhanced tau pathology and neurodegeneration corresponding to central antichol...
Source: Neurodegenerative Diseases - July 1, 2015 Category: Neurology Source Type: research
Beyond the Hypothesis of Serum Anticholinergic Activity in Alzheimer's Disease: Acetylcholine Neuronal Activity Modulates Brain-Derived Neurotrophic Factor Production and Inflammation in the Brain
The brain of Alzheimer's disease (AD) patients is characterized by neurodegeneration, especially an acetylcholine (ACh) neuronal deficit with accumulation of β-amyloid protein, which leads to oxygen stress and inflammation. The active oxygen directly damages the neuron by increasing intracellular Ca2+. The inflammation is due to activation of the microglia, thereby producing cytokines which inhibit the production of brain-derived neurotrophic factor (BDNF). As the BDNF acts by neuronal protection, synaptogenesis and neurogenesis, the reduction of BDNF in the brain of AD patients worsens the symptoms of AD. On the other ha...
Source: Neurodegenerative Diseases - June 30, 2015 Category: Neurology Source Type: research
Demonstrating the Role of Anticholinergic Activity in a Mood Disorder
We report a case of a 54-year-old woman presenting with amnesia, apathy, work-related difficulties and mental stress. At presentation, her Mini-Mental State Examination score was 27 and her serum anticholinergic activity (SAA) was positive without medication or recent physical illnesses. In addition, magnetic resonance imaging revealed mild atrophy of the frontal and temporal lobes, with a relatively intact hippocampus. Consequently, we diagnosed mild cognitive impairment due to Alzheimer's disease and prescribed a cholinesterase inhibitor (donepezil, 10 mg/day); her SAA fully disappeared and clinical symptoms partially re...
Source: Neurodegenerative Diseases - June 30, 2015 Category: Neurology Source Type: research
Anticholinergic Activity and Schizophrenia
In this article, we review the downregulation of acetylcholinergic activity in schizophrenia and discuss the similarity and difference between Alzheimer's disease (AD) and schizophrenia in terms of acetylcholine (ACh) and anticholinergic activity (AA); then, we propose the use of cognition-enhancing therapy for schizophrenia. As ACh regulates an inflammatory system, when the cholinergic system is downregulated to a critical level, the inflammatory system is activated. We consider the possibility that AA appears endogenously in AD and accelerates AD pathology. This hypothesis can also be applied to schizophrenia. In fact, e...
Source: Neurodegenerative Diseases - June 30, 2015 Category: Neurology Source Type: research
