Genetic Variation of MT-ND Genes in Frontotemporal Lobar Degeneration: Biochemical Phenotype-Genotype Correlation
Conclusion: To our knowledge, this is the first report of the complete sequence of the MT-ND genes in FTLD patients and correlation with MRC activity. The high number of mtDNA variations identified and a significant decrease in complex I activity suggest a possible involvement of mtDNA alterations in FTLD. Although the majority of these alterations are not primarily pathogenic, an interaction with other mutations may occur, leading to the disease, worsening its expression or influencing age of onset.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - April 3, 2015 Category: Neurology Source Type: research
Histological Bulbar Manifestations in the ALS Rat
Conclusion: These findings suggest that, from a histological standpoint, the SOD1-G93A rat is a valid model of ALS bulbar symptoms.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - March 23, 2015 Category: Neurology Source Type: research
Title Page
Neurodegener Dis 2015;15:(suppl 1):I-II (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - March 20, 2015 Category: Neurology Source Type: research
Mechanisms, Clinical Strategies, and Promising Treatments of Neurodegenerative Diseases. 12th International Conference AD/PDTM Nice, France, March 18-22, 2015: Abstracts
Neurodegener Dis 2015;15:(suppl 1):1-1969 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - March 20, 2015 Category: Neurology Source Type: research
Abnormal Cochlear Potentials in Friedreich's Ataxia Point to Disordered Synchrony of Auditory Nerve Fiber Activity
Conclusion: These findings suggest that underlying auditory neuropathy in FRDA is a disordered synchrony in auditory nerve fiber discharge, possibly resulting from auditory nerve fiber degeneration and inner hair cell loss.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - March 16, 2015 Category: Neurology Source Type: research
Antecedent Disease Is Less Prevalent in Amyotrophic Lateral Sclerosis
Conclusions: The prevalence of antecedent disease was overall less in the ALS population. We present two potential lines of inquiry to explain these results: (1) ‘Other disease as ALS protection' - antecedent diseases infer biochemical neuroprotection to ALS; (2) ‘ALS as other disease protection' - the underpinnings of ALS could infer protection to other diseases, possibly via the mechanism hypervigilant regulation or ‘too-high' regulatory feedback gains.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - February 19, 2015 Category: Neurology Source Type: research
Is Schizophrenia a Neurodegenerative Disease? Evidence from Age-Related Decline of Brain-Derived Neurotrophic Factor in the Brains of Schizophrenia Patients and Matched Nonpsychiatric Controls
Conclusion: PFC BDNF does not follow a normative linear age effect in schizophrenia patients as they grow older, which may represent a ‘floor effect' due to earlier decline or a survivor cohort of older patient donors who are less susceptible to a schizophrenia-related pathological aging process.Neurodegener Dis 2015;15:38-44 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - February 14, 2015 Category: Neurology Source Type: research
Erratum
Neurodegener Dis 2015;15:62 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - February 14, 2015 Category: Neurology Source Type: research
