Heart Rate Variability during Wake and Sleep in Huntington ’s Disease Patients: An Observational, Cross-Sectional, Cohort Study
Conclusion: Our results show that HD patients have higher heart rate than controls, during wake and NREM, but not during REM sleep. Among HRV parameters, the most relevant difference regarded the LF component, which reflects, at least partially, the ortho-sympathetic output. Our results confirm the involvement of autonomic nervous system in HD and demonstrate that it is evident during both wake and sleep. (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - November 8, 2021 Category: Neurology Source Type: research
Heart Rate Variability during wake and sleep in Huntington ’s Disease patients. An observational, cross-sectional, cohort study.
Introduction
Autonomic dysfunction has been reported as one of non-motor manifestations of both pre-symptomatic and manifest Huntington ’s Disease (HD). The aim of our study was to evaluate heart rate variability (HRV) during wake and sleep in a cohort of patients with manifest HD.
Methods
Thirty consecutive patients with manifest HD were enrolled, 14 men and 16 women, mean age 57.3±12.2 years. All patients underwent full-night a ttended video-polysomnography. HRV was analyzed during wake, NREM and REM sleep, in time and frequency domain. Results were compared with a control group of healthy volunteers matched for age ...
Source: Neurodegenerative Diseases - November 8, 2021 Category: Neurology Source Type: research
Review of available data for the efficacy and effectiveness of nabiximols oromucosal spray (Sativex ) in multiple sclerosis patients with moderate to severe spasticity
Background: Sativex (USAN: nabiximols) oromucosal spray is indicated for treatment of multiple sclerosis (MS) patients with moderate to severe spasticity and inadequate response to other antispasticity medications who demonstrate clinically significant improvement during an initial trial of therapy. This narrative review investigated the efficacy and effectiveness of nabiximols oromucosal spray for moderate to severe MS spasticity by examining spasticity 0 10 Numerical Rating Scale (NRS) data from interventional and observational studies which featured a 4-week trial period as per the European Union approved label.
Summ...
Source: Neurodegenerative Diseases - November 3, 2021 Category: Neurology Source Type: research
Tit for tat: costly punishment in manifest Huntington ’s disease
Objective: We aimed to investigate costly punishment in patients with HD.
Background: Huntington ’s disease (HD) is an autosomal dominant neurodegenerative disease with motor, cognitive, and psychiatric symptoms. As neuropsychiatric abnormalities often precede motor symptoms, we wanted to assess whether costly punishment is part of the neuropsychological profile of patients with HD.
Methods: A total of 40 non demented subjects were prospectively enrolled in this study with a between-subject design comparing manifest HD patients (n=18) to healthy controls (HC; n=22). All participants performed eight rounds of a costly p...
Source: Neurodegenerative Diseases - October 27, 2021 Category: Neurology Source Type: research
Cerebrospinal fluid levels of 5-hydroxyindoleacetic acid in Parkinson ’s disease and atypical parkinsonian syndromes
Background: Various cerebrospinal fluid (CSF) biomarkers are studied in Parkinson ’s disease (PD) and atypical parkinsonian syndromes (APS). Several studies found reduced 5-hydroxyindoleacetic acid (5-HIAA), the main serotonin metabolite, in PD. There is little evidence regarding its levels in APS.
Methods: We measured 5-HIAA in the CSF of 90 PD patients, 16 MSA patients, 26 pr ogressive supranuclear palsy (PSP) patients, 11 corticobasal degeneration (CBD) patients, and 31 controls. We also compared the values in depressed and non-depressed patients.
Results: There was a statistically significant difference in CSF 5-HIA...
Source: Neurodegenerative Diseases - October 25, 2021 Category: Neurology Source Type: research
Cancer in Parkinson ’s Disease: An Approximation to the Main Risk Factors
Conclusions: Our study identified several factors, genetic and nongenetic, which contribute to the risk for cancer in PD. (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - October 21, 2021 Category: Neurology Source Type: research
Cancer in Parkinson Disease: an approximation to the main risk factors
Abstract
Background: Many evidences suggest a pathological link between neurodegenerative diseases and cancer. In fact, several epidemiologic studies indicate a a decreased incidence of most cancer types in Parkinson's disease (PD) patients and some PD genes are involved in cancer networks.
Objective : The aim of this study is to assess the influence of several factors in the risk of cancer in a cohort of 753 PD patients and to study how these variables interact with each other.
Methods: We analyzed the effect of gender, tobacco, alcohol, type of PD (genetic (gPD) or idiopathic PD (iPD)) and two genetic variants, previo...
Source: Neurodegenerative Diseases - October 21, 2021 Category: Neurology Source Type: research
Association between excessive daytime sleepiness and the cholinergic ascending reticular system in Parkinson ’s disease
(Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - September 24, 2021 Category: Neurology Source Type: research
Characteristics of late-onset amyotrophic lateral sclerosis in a Chinese cohort
(Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - August 20, 2021 Category: Neurology Source Type: research
The impact of the COVID-19 pandemic on dementia risk: Potential pathways to cognitive decline
(Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - July 28, 2021 Category: Neurology Source Type: research
The effects of 8-week combined exercise training on inflammatory markers in women with multiple sclerosis
(Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - July 20, 2021 Category: Neurology Source Type: research
Computerized Simple Reaction Time and Balance in Nondemented Parkinson ’s Patients
Conclusions: Poor performance in a simple reaction task can predict altered PI and can complement staging and evaluation in PD patients.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - July 16, 2021 Category: Neurology Source Type: research
Extending the Spectrum of Nonmotor Symptoms with Olfaction in Premotor Huntington ’s Disease: A Pilot Study
Conclusions: The results of this pilot study suggest that olfactory dysfunction may be an early nonmotor symptom of HD and could be a potential marker to assess disease progression. (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - July 9, 2021 Category: Neurology Source Type: research
Extending the spectrum of non-motor symptoms with olfaction in pre-motor Huntington ’s disease – a pilot study
(Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - July 9, 2021 Category: Neurology Source Type: research
Involvement of the Auditory Pathway in Spinocerebellar Ataxia Type 7
Conclusions: BAEP tests revealed functional involvement of the auditory pathway in SCA7 (mainly at) peripheral portions, which gave new insights into the disease physiopathology different from SCA2 and may unravel distinct pathoanatomical effects of polyQ expansions in the central nervous system.Significance: These findings offer important insights into the distinctive disease mechanisms in SCA7 and SCA2, which could be useful for differential diagnosis and designing specific precision medicine approaches for both conditions.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - July 9, 2021 Category: Neurology Source Type: research
