The two-way route between delirium disorder and dementia: insights from Covid-19
Background. Delirium disorder is a frequent neurological complication of SARS-CoV-2 infection and associated with an increased disease severity and mortality. Cognitive impairment is a major risk factor for developing delirium disorder during Covid-19, which, in turn, increases the risk of subsequent neurological complications and cognitive decline. Summary. The bidirectional connection between delirium disorder and dementia likely resides at multiple levels, and its pathophysiological mechanisms during Covid-19 include endothelial damage, blood-brain barrier dysfunction and local inflammation, with activation of microglia...
Source: Neurodegenerative Diseases - April 13, 2023 Category: Neurology Source Type: research
Clinical manifestations associated with the domain-containing protein 2 (DDHD2) gene mutation in an Iranian family with Spastic Paraplegia 54
Conclusion: The clinical symptoms in our cases were similar to the previously reported phenotype of SPG54. Our results deepen the molecular and clinical spectrum of SPG54 to facilitate future diagnoses. (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - March 28, 2023 Category: Neurology Source Type: research
Age of Onset and Length of Survival of Queensland Patients with Amyotrophic Lateral Sclerosis: Details of Subjects with Early Onset and Subjects with Long Survival
Conclusion: Our study confirms that ALS is more prevalent in males and that spinal onset is more common than bulbar onset. Males have earlier onset but longer survival. We found that overall, patients with classical ALS have worse survival than ALS variants, but some patients who were considered to have classical ALS had long survival. This study confirms the similarity of ALS in our region to ALS in other geographical regions.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - December 30, 2022 Category: Neurology Source Type: research
Age of Onset and Length of Survival of Queensland Patients with Amyotrophic Lateral Sclerosis: Details of Subjects with Early Onset and Subjects with Long Survival
Conclusion: Our study confirms that ALS is more prevalent in males and that spinal onset is more common than bulbar onset. Males have earlier onset but longer survival. We found that overall, patients with classical ALS have worse survival than ALS variants, but some patients who were considered to have classical ALS had long survival. This study confirms the similarity of ALS in our region to ALS in other geographical regions. (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - December 30, 2022 Category: Neurology Source Type: research
Age of onset and length of survival of Queensland patients with amyotrophic lateral sclerosis: with details of subjects with early onset and subjects with long survival.
Conclusion: Our study confirms that ALS is more prevalent in males, and that spinal onset is more common than bulbar onset. Males have earlier onset but lon ger survival. We found that overall, patients with classical ALS have worse survival than ALS variants, but some patients who were considered to have classical ALS had long survival. This study confirms the similarity of ALS in our region to ALS in other geographical regions. (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - December 30, 2022 Category: Neurology Source Type: research
The Immunomodulatory Potential Role of Mesenchymal Stem Cells in Diseases of the Central Nervous System
Conclusion: It was shown that MSCs, independent from origin or administration pathway, can reduce inflammation and help in the recovery and preservation of injured neural tissue. Thus, the use of MSCs represents a potential therapeutic option in the treatment of neurological disorders mediated by inflammatory processes.Neurodegener Dis 2022;22:68 –82 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - November 17, 2022 Category: Neurology Source Type: research
The Immunomodulatory Potential Role of Mesenchymal Stem Cells in Diseases of the Central Nervous System
Conclusion: It was shown that MSCs, independent from origin or administration pathway, can reduce inflammation and help in the recovery and preservation of injured neural tissue. Thus, the use of MSCs represents a potential therapeutic option in the treatment of neurological disorders mediated by inflammatory processes. (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - November 17, 2022 Category: Neurology Source Type: research
Natural Age-Related Slow-Wave Sleep Alterations Onset Prematurely in the Tg2576 Mouse Model of Alzheimer ’s Disease
Conclusion: Therefore, our results indicate that at the plaque-free disease stage, diminished sleep quality is present in Tg2576 mice which resembles aged healthy controls, suggesting an early-onset of sleep-wake deterioration in murine AD. Whether such disturbances in the natural patterns of sleep could in turn worsen disease progression warrants further exploration.Neurodegener Dis 2022;22:55 –67 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - October 27, 2022 Category: Neurology Source Type: research
Natural age-related slow-wave sleep alterations onset prematurely in the Tg2576 mouse model of Alzheimer ’s disease
Conclusion: Therefore, our results indicate that at plaque-free disease stage, diminished sleep quality is present in Tg2576 mice which resembles aged healthy controls, suggesting an early-onset of sleep-wake deterioration in murine AD. Whether such dis turbances in the natural patterns of sleep could in turn worsen disease progression warrants further exploration. (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - October 27, 2022 Category: Neurology Source Type: research
4-Phthalimidobenzenesulfonamide Derivatives as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: DFTs, 3D-QSAR, ADMET, and Molecular Dynamics Simulation
Conclusion: Findings of the current study suggested that these derivatives are potent inhibitors of cholinesterase enzyme.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - October 26, 2022 Category: Neurology Source Type: research
4-Phthalimidobenzenesulfonamide Derivatives as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: DFTs, 3D-QSAR, ADMET, and Molecular Dynamic Simulation
Conclusion: Findings of current study suggested that these derivatives are potent inhibitors of cholinesterase enzyme. (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - October 26, 2022 Category: Neurology Source Type: research
CSF A β < sub > 40 < /sub > and P-Tau < sub > 181 < /sub > Might Differentiate Atypical from Typical AD Phenotypes: Preliminary Evidence
Conclusions: The present study delivers promising, albeit preliminary, evidence on the utility of A β40 and P-tau181 CSF biomarkers in differentiating atypical from typical A β42/40-confirmed AD phenotypes, prompting further research and confirmation on larger cohorts.Neurodegener Dis 2022;22:83 –86 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - September 15, 2022 Category: Neurology Source Type: research
CSF A β < sub > 40 < /sub > and P-Tau < sub > 181 < /sub > Might Differentiate Atypical from Typical AD Phenotypes: Preliminary Evidence
Conclusions: The present study delivers promising, albeit preliminary, evidence on the utility of A β40 and P-tau181 CSF biomarkers in differentiating atypical from typical A β42/40-confirmed AD phenotypes, prompting further research and confirmation on larger cohorts.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - September 15, 2022 Category: Neurology Source Type: research
CSF A β40 and P-tau181 might differentiate atypical from typical AD phenotypes: preliminary evidence
Conclusions. The present study delivers promising, albeit preliminary, evidence on the utility of Aβ40 and P-tau181 CSF biomarkers in diff erentiating atypical from typical Aβ42/40-confirmed AD phenotypes, prompting further research and confirmation on larger cohorts. (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - September 15, 2022 Category: Neurology Source Type: research
Association between Gut Microbiota with Mild Cognitive Impairment and Alzheimer ’s Disease in a Thai Population
Conclusion: There was a relationship between the composition of the gut microbiome and neurodegenerative disorders, including MCI and AD. Reduction ofClostridiaceae and increases inEnterobacteriaceae andBacteroides were associated with persons with MCI and AD, consistent with previous studies. The altered gut microbiome could be potentially targeted for the early diagnosis of dementia and the reduction of AD risk.Neurodegener Dis 2022;22:43 –54 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - September 7, 2022 Category: Neurology Source Type: research
