Neurodegeneration and the Cerebellum
Conclusions: Altered cerebellum in neurodegeneration can provide important diagnostic and pathologic insights into both predicting disease progression and network dysfunction.Neurodegener Dis 2017;17:155-165 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - May 2, 2017 Category: Neurology Source Type: research
Patterns of Microglial Cell Activation in Alzheimer Disease and Frontotemporal Lobar Degeneration
Conclusions: Our work expands the knowledge of the distribution and magnitude of microglial activation in these disorders. Additionally, we found some microglial circuit-specific patterns that could help to explain some of the clinical overlap between AD and FTLD-TDP, namely in memory deficits.Neurodegener Dis 2017;17:145-154 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - April 26, 2017 Category: Neurology Source Type: research
Home-Based Physical Behavior in Late Stage Parkinson Disease Dementia: Differences between Cognitive Subtypes
Background: For the early diagnosis of Parkinson disease dementia (PDD), objective home-based tools are needed to quantify even mild stages of dysfunction of the activities of daily living (ADL).Objectives: In this pilot study, home-based physical behavior was assessed to examine whether it is possible to distinguish mild cognitive impairment (PD-MCI) from PDD.Methods: Fifty-five patients with mild to severe Parkinson disease (PD) participated in this cross-sectional study. Based on comprehensive neuropsychological testing, PD patients were classified as cognitively nonimpaired (PD-NC), PD-MCI or PDD. For physical behavior...
Source: Neurodegenerative Diseases - April 25, 2017 Category: Neurology Source Type: research
Title Page
Neurodegener Dis 2017;17:(suppl 1):I-II (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - March 16, 2017 Category: Neurology Source Type: research
Mechanisms, Clinical Strategies, and Promising Treatments of Neurodegenerative Diseases. 13th International Conference AD/PD < sup > TM < /sup > Vienna, Austria, March 29 to April 2, 2017: Abstracts
Neurodegener Dis 2017;17:(suppl 1):1-1890 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - March 16, 2017 Category: Neurology Source Type: research
Patterns of Eye Movement Impairment Correlate with Regional Brain Atrophy in Neurodegenerative Parkinsonism
Background: One common feature of neurodegenerative parkinsonism including Parkinson's disease (PD), multisystem atrophy (MSA), and progressive supranuclear palsy (PSP) is altered eye movement control. Characteristic regional structural atrophy patterns in MRI can be observed in PD, MSA, and PSP.Objective: To investigate the association between eye movement disturbances and regional brain atrophy in patients with PD, MSA, and PSP.Methods: High-resolution 3-dimensional T1-weighted MRI images and video-oculographic recordings (EyeLink ®) were obtained from 39 PD, 32 PSP, and 18 MSA patients and 24 matched healthy control su...
Source: Neurodegenerative Diseases - March 7, 2017 Category: Neurology Source Type: research
Neuropsychiatric Symptoms in Alzheimer Disease, Vascular Dementia, and Mixed Dementia
Background/Aims: Neuropsychiatric symptoms (NPS) are common in Alzheimer disease (AD) and vascular dementia (VaD), and are distressful to patients and caregivers. NPS are likely related to the underlying pathology. Previous studies suggest that frontal lobe lesions and vascular changes such as white matter hyperintensities (WMH) have a significant association with specific NPS. The current study aimed to compare NPS in patients with AD, VaD, and mixed AD/VaD, and to evaluate the differences in the prevalence of NPS in relation to frontal WMH volume.Methods: In total, 180 patients with NPS and MRI data (92 probable AD, 51%;...
Source: Neurodegenerative Diseases - February 28, 2017 Category: Neurology Source Type: research
Environmental and Occupational Exposures and Amyotrophic Lateral Sclerosis in New England
Conclusions: Our study contributes to a growing body of literature implicating occupational- and hobby-related toxicant exposures in ALS etiology. These epidemiologic study results also provide motivation for future evaluation of water-body-related risk factors.Neurodegener Dis 2017;17:110-116 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - January 25, 2017 Category: Neurology Source Type: research
Identification of Small Peptides in Human Cerebrospinal Fluid upon Amyloid- β Degradation
Conclusion: Our results indicate that a substantial amount of A β40 in human brains is degraded via a neprilysin- or insulin-degrading enzyme-independent pathway.Neurodegener Dis 2017;17:103-109 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - January 19, 2017 Category: Neurology Source Type: research
Precuneal Thickness and Depression in Parkinson Disease
Background: Depression-related gray matter changes in Parkinson disease (PD) patients have been reported, although studies investigating cortical thickness in early-stage disease are lacking.Objective: We aimed to evaluate cortical changes related to depression in early-stage PD patients with an extensive neuropsychological evaluation.Methods: 17 PD patients and 22 healthy controls underwent a 1.5-T brain MR protocol, and voxel-wise differences in cortical thickness among patients with (n = 6) and without (n = 11) depression and controls were evaluated using FreeSurfer software.Results: Cortical thickness was increased in ...
Source: Neurodegenerative Diseases - November 24, 2016 Category: Neurology Source Type: research
Arterial Stiffness and Cardiovascular Autonomic Dysfunction in Patients with Parkinson's Disease
Conclusion: These findings suggest that cardiovascular autonomic dysfunction is associated with arterial stiffness in PD. PD itself does not affect arterial stiffness, whereas autonomic blood pressure disturbances influence alterations in arterial stiffness and architectural changes in the arteries of PD patients.Neurodegener Dis 2017;17:89-96 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - October 26, 2016 Category: Neurology Source Type: research
Cerebrospinal Fluid Progranulin, but Not Serum Progranulin, Is Reduced in GRN-Negative Frontotemporal Dementia
Conclusions: Our results indicate that central nervous progranulin reduction is not restricted to the relatively rare cases of FTD caused byGRN LoF mutations, but also contributes to the more commonGRN-negative forms of FTD. Central nervous progranulin reduction might reflect a partially distinct pathogenic mechanism underlying FTD neurodegeneration and is not directly linked to tau alterations.Neurodegener Dis 2017;17:83-88 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - October 20, 2016 Category: Neurology Source Type: research
Cerebrospinal Fluid Progranulin, but Not Serum Progranulin, Is Reduced in < b > < i > GRN < /i > < /b > -Negative Frontotemporal Dementia
Conclusions: Our results indicate that central nervous progranulin reduction is not restricted to the relatively rare cases of FTD caused byGRN LoF mutations, but also contributes to the more commonGRN-negative forms of FTD. Central nervous progranulin reduction might reflect a partially distinct pathogenic mechanism underlying FTD neurodegeneration and is not directly linked to tau alterations.Neurodegener Dis 2017;17:83-88 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - October 19, 2016 Category: Neurology Source Type: research
Cl-NQTrp Alleviates Tauopathy Symptoms in a Model Organism through the Inhibition of Tau Aggregation-Engendered Toxicity
Alzheimer's disease (AD) is the most abundant tauopathy and is characterized by A β-derived plaques and tau-derived tangles, resulting from the unfolding of the corresponding monomeric subunits into ordered β-sheet oligomers and fibrils. Intervening in the toxic aggregation process is a promising therapeutic approach, but, to date, a disease-modifying therapy is neither availab le for AD nor for other tauopathies. Along these lines, we have previously demonstrated that a small naphthoquinone-tryptophan hybrid, termed NQTrp, is an effective modulator of tauopathy in vitro and in vivo. However, NQTrp is difficult to synthe...
Source: Neurodegenerative Diseases - October 19, 2016 Category: Neurology Source Type: research
Visual Hallucination and Pattern of Brain Degeneration in Parkinson's Disease
Conclusions: Gray matter degenerations from the parieto-temporal junction to the parieto-occipital and temporo-occipital regions may be responsible for VH on the typical timeline of PD progression.Neurodegener Dis 2017;17:63-72 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - October 19, 2016 Category: Neurology Source Type: research
