Combinations of Multiple Neuroimaging Markers using Logistic Regression for Auxiliary Diagnosis of Alzheimer Disease and Mild Cognitive Impairment
Conclusion: Using a combination of different indices, the results confirmed the initial hypothesis that different biomarkers were potentially complementary, and thus the conjoint analysis of multiple information from multiple sources would improve the capability to identify diseases such as AD and mild cognitive impairment.Neurodegener Dis 2018;18:91 –106 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - June 5, 2018 Category: Neurology Source Type: research
Gradual Phenotype Development in Huntington Disease Transgenic Minipig Model at 24 Months of Age
Conclusions: The gradual development of a neurodegenerative phenotype, ac companied with testicular degeneration, is observed in 24- month-old TgHD minipigs.Neurodegener Dis 2018;18:107 –119 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - June 5, 2018 Category: Neurology Source Type: research
Education-Adjusted Normality Thresholds for FDG-PET in the Diagnosis of Alzheimer Disease
Conclusion: These data show that education, as a proxy of reserve, is not a major confounder in the diagnostic accuracy of FDG-PET in AD and the adoption of education-adjusted thresholds is not required in daily practice.Neurodegener Dis 2018;18:120 –126 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - June 5, 2018 Category: Neurology Source Type: research
Association between White Matter Lesions and Non-Motor Symptoms in Parkinson Disease
Conclusions: Among the non-motor symptoms, fatigue, depression, anxiety, and quality of life were significantly affected by WMLs in PD. Confirmation of the possible role of WMLs in non-motor symptoms associated with PD in a prospective manner may be crucial not only for understanding non-motor symptoms but also for the development of treatment strategies.Neurodegener Dis 2018;18:127 –132 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - June 5, 2018 Category: Neurology Source Type: research
Characteristics of Early Oropharyngeal Dysphagia in Patients with Multiple System Atrophy
Conclusion: Understanding early OD characteristics in patients with MSA and the differences between MSA subtypes could be helpful in managing dysphagia in patients with MSA. Several dysphagia symptoms similar to those of Parkinson disease were frequently observed in MSA-P, but not in MSA-C. A follow-up study is needed to elucidate the natural course of OD in MSA patients and the difference between MSA subtypes.Neurodegener Dis 2018;18:84 –90 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - April 5, 2018 Category: Neurology Source Type: research
Whole-Genome Linkage Analysis with Whole-Exome Sequencing Identifies a Novel Frameshift Variant in < b > < i > NEFH < /i > < /b > in a Chinese Family with Charcot-Marie-Tooth 2: A Novel Variant in < b > < i > NEFH < /i > < /b > for Charcot-Marie-Tooth 2
Conclusions: We identified a novel stop loss variant inNEFH that is likely pathogenic for CMT2, and the results provide further evidence for the role of an aberrant assembly of neurofilament in CMT.Neurodegener Dis 2018;18:74 –83 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - March 27, 2018 Category: Neurology Source Type: research
Cognitive Reserve Hypothesis in Frontotemporal Dementia: Evidence from a Brain SPECT Study in a Series of Greek Frontotemporal Dementia Patients
Conclusion: In the present study, lifetime participation in leisure time activities was found to mitigate the burden of disease in bvFTD and PPA patients. Moreover, FTD patients with a higher educational attainment were able to cope better with greater brain damage. Determination of the most suitable activities to build an adequate level of CR is crucial for dementia prevention.Neurodegener Dis 2018;18:69 –73 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - March 8, 2018 Category: Neurology Source Type: research
Phenotypic Variability in Autosomal Dominant Familial Alzheimer Disease due to the S170F Mutation of Presenilin-1
Conclusion: The variable clinical findings associated with the S170F mutation highlight the relevance of atypical phenotypes in the context of research and under a clinical perspective. CSF sampling and detection of A β species may be essential to indicate AD pathology in unclear cases presenting with cognitive and motor symptoms at a younger age.Neurodegener Dis 2018;18:57-68 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - February 21, 2018 Category: Neurology Source Type: research
Elevated Global DNA Methylation Is Not Exclusive to Amyotrophic Lateral Sclerosis and Is Also Observed in Spinocerebellar Ataxia Types 1 and 2
We report a significant elevation in global 5-mC levels of about 2–7% on average for sALS (p #x3c; 0.01 [F(1, 243) = 9.159,p = 0.0027]) and various forms of fALS along with SCA1 (p #x3c; 0.01 [F(1, 83) = 11.285],p = 0.0012) and SCA2 (p #x3c; 0.001 [F(1, 122) = 29.996,p = 0.0001]) when compared to age- and sex-matched healthy controls.C9orf72 expansion carrier ALS patients exhibit the highest global 5-mC levels along withC9orf72 promoter hypermethylation. We failed to measure global 5-hydroxymethylcytosine (5-hmC) levels in blood, probably due to the very low levels of 5-hmC and the limitations of the commercially availab...
Source: Neurodegenerative Diseases - February 9, 2018 Category: Neurology Source Type: research
Overexpression of SNX3 Decreases Amyloid- β Peptide Production by Reducing Internalization of Amyloid Precursor Protein
Conclusion: These results provide evidence that SNX3 regulates A β production by influencing the internalization of APP.Neurodegener Dis 2018;18:26 –37 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - February 7, 2018 Category: Neurology Source Type: research
Extravascular CD3+ T Cells in Brains of Alzheimer Disease Patients Correlate with Tau but Not with Amyloid Pathology: An Immunohistochemical Study
Conclusions: Our data support the notion of T-cell occurrence in AD brains and suggest that, in advanced stages of AD, T-cell extravasation is driven by tau-related neurodegenerative changes rather than by cerebral amyloidosis. T cells could be crucial for driving the amyloid-independent phase of the AD pathology.Neurodegener Dis 2018;18:49-56 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - February 6, 2018 Category: Neurology Source Type: research
Novel Translational Research Methodology and the Prospect to a Better Understanding of Neurodegenerative Disease
Neurodegener Dis 2018;18:1 –4 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - January 16, 2018 Category: Neurology Source Type: research
Aberrant Connectivity in Mild Cognitive Impairment and Alzheimer Disease Revealed by Multimodal Neuroimaging Data
In this study, 116 MCI, 116 NC and 116 Alzheimer disease (AD) subjects from the Alzheimer's Disease Neuroimaging Initiative were included for the evaluation of the brain covariance graphic model. Sparse inverse covariance estimation was utilized to get the graphic model.Results: The connections among different brain regions were quite different between NC and MCI or between MCI and AD subjects (p (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - January 15, 2018 Category: Neurology Source Type: research
Characteristic Motor and Nonmotor Symptoms Related to Quality of Life in Drug-Na ïve Patients with Late-Onset Parkinson Disease
Background/Aims: Unlike young-onset Parkinson disease (YOPD), characteristics of late-onset PD (LOPD) have not yet been clearly elucidated. We investigated characteristic features and symptoms related to quality of life (QoL) in LOPD patients.Methods: We recruited drug-na ïve, early PD patients. The patient cohort was divided into 3 subgroups based on patient age at onset (AAO): the YOPD group (AAO (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - January 12, 2018 Category: Neurology Source Type: research
Acknowledgement to Reviewers
Neurodegener Dis 2017;17:338 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - December 14, 2017 Category: Neurology Source Type: research
