Mutant G2019S-LRRK2 Induces Abnormalities in Arteriolar Cerebral Blood Volume in Mouse Brains: An MRI Study
Conclusions: Alterations in the blood volume of small arteries and arterioles (CBVa) were detected in the G2019S-LRRK2 mouse model of PD. The opposite changes in CBVa in the SN and the cortex indicate that PD pathology may have differential effects in different brain regions. Our results suggest the potential value of CBVa as a marker for clinical PD studies.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - November 5, 2020 Category: Neurology Source Type: research
Effects of Rivastigmine on Patients with Spinocerebellar Ataxia Type 3: A Case Series of Five Patients
Conclusions: Contrary to our hypothesis, we observed no improvement of gait parameters as assessed by SARA and GAIT Rite®, but coordination abilities were improved. Rivastigmine was well tolerated, but known side effects of rivastigmine, such as deterioration of asthma, may appear. Further trials in larger cohorts are needed to confirm our findings.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - September 29, 2020 Category: Neurology Source Type: research
Prefrontal Cortex Transcriptomic Deconvolution Implicates Monocyte Infiltration in Parkinson ’s Disease
Conclusion and Discussion: The findings corroborate previous reports and suggest monocytes may be involved in PD pathogenesis.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - September 25, 2020 Category: Neurology Source Type: research
What Shall We Do for the Patients with Shaky Leg Syndrome? A Review of 23 Patients
In conclusion, we found that different types of OT and orthostatic myoclonus were diagnosed by electrophysiological evaluation and neuroimaging tools even if they showed the same symptoms as “shaky leg.” In addition, it is possible to roughly estimate the response to med ication according to the type of OT and the cause. To clarify the pathophysiology of OT, a large number of longitudinal cohort studies and detailed neuroimaging and electrophysiological evaluations are needed.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - September 10, 2020 Category: Neurology Source Type: research
Ferroptosis Is Regulated by Mitochondria in Neurodegenerative Diseases
Background: Neurodegenerative diseases are characterized by a gradual decline in motor and/or cognitive function caused by the selective degeneration and loss of neurons in the central nervous system, but their pathological mechanism is still unclear. Previous research has revealed that many forms of cell death, such as apoptosis and necrosis, occur in neurodegenerative diseases. Research in recent years has noticed that there is a new type of cell death in neurodegenerative diseases: ferroptosis. An increasing body of literature provides evidence for an involvement of ferroptosis in neurodegenerative diseases.Summary: In ...
Source: Neurodegenerative Diseases - August 19, 2020 Category: Neurology Source Type: research
Publisher's Note
Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - July 16, 2020 Category: Neurology Source Type: research
First Recognized Patient with Genetic Vitamin E Deficiency Stable after 36 Years of Controlled Supplement Therapy
Discussion: In this VED patient, a specified and carefully controlled high-dose vitamin E therapy has prevented any recognizable progression of the neurodegenerative process over more than 3 decades of observation.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - July 3, 2020 Category: Neurology Source Type: research
Analysis of Neuropsychiatric Symptoms in Patients with Alzheimer ’s Disease Using Quantitative EEG and sLORETA
Conclusion: The results of the present study showed that both classical EEG spectral and EEG source analysis could differentiate patients with and without NPSs, especially psychosis and apathy subdomains. Spectral and sLORETA analyses provided information helpful for a better characterization in patients with NPSs.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - July 1, 2020 Category: Neurology Source Type: research
Magnetic Resonance Spectroscopy following Mild Traumatic Brain Injury: A Systematic Review and Meta-Analysis on the Potential to Detect Posttraumatic Neurodegeneration
Conclusions: MRS pinpoints changes in posttraumatic brain metabolism that correlate with cognitive dysfunction and, thus, might possibly help to detect mTBI patients at risk for unfavorable outcome or posttraumatic neurodegeneration early.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - July 1, 2020 Category: Neurology Source Type: research
Clinical Phenotype of < b > < i > LRRK2 < /i > < /b > R1441C in 2 Chinese Sisters
This report is from an ongoing multicentre study in which next-generation sequencing-based PD gene panel testing has so far been conducted on 499 PD patients of various ethnicities from Malaysia. We describe 2 sisters of Chinese ancestry with PD who carry the R1441C mutation inLRRK2 (which in Asians has been reported in only 2 Chinese patients previously), and highlight interesting clinical observations made over a decade of close follow-up. We further explored the feasibility of using a brief, expert-administered rating scale (the Clinical Impression of Severity Index; CISI-PD) to capture data on global disease severity i...
Source: Neurodegenerative Diseases - June 24, 2020 Category: Neurology Source Type: research
Contents Vol.19, 2019
Neurodegener Dis 2019;19:I –VI (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - June 17, 2020 Category: Neurology Source Type: research
Acknowledgement to Reviewers
Neurodegener Dis 2019;19:244 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - June 17, 2020 Category: Neurology Source Type: research
A Comparative Study of the Diagnostic Potential of Plasma and Erythrocytic α-Synuclein in Parkinson’s Disease
Conclusion: Our results suggest that plasma α-Syn could be a specific and sensitive potential diagnostic biomarker for PD.Neurodegener Dis 2019;19:204 –210 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - June 2, 2020 Category: Neurology Source Type: research
Neuropsychiatric Traits Associated with Refractory Impulse Control Disorder in Parkinson ’s Disease
Conclusions: Our results suggest that assessment of obsessive compulsiveness may be useful for predicting the refractoriness of ICD behaviors in planning an interventional treatment for ICD in PD.Neurodegener Dis 2019;19:171 –177 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - May 26, 2020 Category: Neurology Source Type: research
CREB Protects against Temporal Lobe Epilepsy Associated with Cognitive Impairment by Controlling Oxidative Neuronal Damage
Conclusion: CREB plays a significant role in TLE-associated oxidative neuronal damage and memory impairment. This novel finding provides the evidence of the relationship between CREB and mitochondrial oxidative stress and cognitive dysfunction in epilepsy. Mitochondria-specific antioxidants such as MitoQ may alleviate TLE-associated cognitive dysfunction through activation of CREB and its downstream signaling pathways.Neurodegener Dis 2019;19:225 –237 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - May 15, 2020 Category: Neurology Source Type: research
