Brain Structural Plasticity Associated with Maternal Caregiving in Mothers: A Voxel- and Surface-Based Morphometry Study
Conclusion: These results suggest that the brains of mothers exhibit adaptive structural dynamic plasticity. These findings provide a neuroanatomical basis for understanding how mothers process emotional sensory information during the postpartum period.Neurodegener Dis 2019;19:192 –203 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - May 12, 2020 Category: Neurology Source Type: research
Associations of Neprilysin Activity in CSF with Biomarkers for Alzheimer ’s Disease
Conclusions: Our results on CSF-NEP are compatible with the assumption that local degradation, amongst other mechanisms of amyloid clearance, plays a role in the development of Alzheimer ’s pathology. In addition, CSF-NEP is associated with the extent and the rate of neurodegeneration.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - July 2, 2019 Category: Neurology Source Type: research
Novel and Recurring < b > < i > NOTCH3 < /i > < /b > Mutations in Two Chinese Patients with CADASIL
Conclusions: We identified 2NOTCH3 mutations as likely genetic causes for CADASIL in these 2 patients. Our findings broaden the mutational spectrum of theNOTCH3 gene accountable for CADASIL. Clinical manifestations supplemented with molecular genetic analyses are critical for accurate diagnosis, the provision of genetic counseling, and the development of therapies for CADASIL.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - June 18, 2019 Category: Neurology Source Type: research
Age-Related Oxidative Changes in Primary Porcine Fibroblasts Expressing Mutated Huntingtin
Conclusions: Our results unravel phenotypic alterations in primary fibroblasts isolated from the TgHD minipig model at the age of 48 months. Importantly, nDNA damage appears to precede these phenotypic alterations. Our results highlight the impact of fibroblasts from TgHD minipigs in studying the molecular mechanisms of HD pathophysiology that gradually occur with age.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - June 5, 2019 Category: Neurology Source Type: research
“A Battle You Would Never Choose to Fight”: The Management of Neurodegenerative Diseases as a Societal Challenge
Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - June 4, 2019 Category: Neurology Source Type: research
Psychosocial Impact of Dysarthria: The Patient-Reported Outcome as Part of the Clinical Management
Conclusions: All patients reported a communication complaint, attested by the DIP scores, despite the fact that not all patients, notably PD, ataxic, and PSP patients, had an intelligibility deficit. The DIP should be used in clinical practice to contribute to a holistic evaluation and management of functional communication in patients with dysarthria.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - May 21, 2019 Category: Neurology Source Type: research
Physician and Surrogate Agreement with Assisted Dying and Continuous Deep Sedation in Advanced Dementia in Switzerland
Conclusions: The surrogates were more agreeable to considering assisted dying in the setting of advanced dementia than the physicians, and about half of the participants in both groups reported CDS to be an appropriate option for this population.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - April 24, 2019 Category: Neurology Source Type: research
Contents Vol. 18, 2018
Neurodegener Dis 2018;18:I –VI (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - April 15, 2019 Category: Neurology Source Type: research
Role of < b > < i > MAPT < /i > < /b > in Pure Motor Neuron Disease: Report of a Recurrent Mutation in Italian Patients
The aim of our study was to evaluate the role of mutations in theMAPT gene in patients with pure amyotrophic lateral sclerosis (ALS). A cohort of 120 ALS patients, both sporadic and familial, without cognitive impairment was analyzed by next-generation sequencing with a multiple-gene panel comprising 23 genes, includingMAPT, known to be associated with ALS and frontotemporal dementia. The presence of theC9orf72 expansion was also investigated. Twelve patients had mutations in theSOD1, TARDBP, MATR3, andFUS genes, while 10 patients carried theC9orf72 expansion. One female patient was found to carry the D348G mutation inMAPT...
Source: Neurodegenerative Diseases - March 20, 2019 Category: Neurology Source Type: research
Association between Primary Open-Angle Glaucoma and Cognitive Impairment as Measured by the Montreal Cognitive Assessment
Conclusions: POAG cases and controls had similar neurocognitive function as measured by the MoCA. Among POAG cases, worse VF loss was associated with lower MoCA. Future studies are needed to further elucidate the clinical effect of neuropathy in POAG.Neurodegener Dis 2018;18:315 –321 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - March 20, 2019 Category: Neurology Source Type: research
The Precuneus – A Witness for Excessive Aβ Gathering in Alzheimer’s Disease Pathology
Conclusions: The voxel-wise semiquantitative analysis shows that the precuneus is a region with higher vulnerability to A β depositions when compared to other cortical regions in both MCI-AD and ADD subjects. We think that the precuneus is a promising PET-based outcome measure for clinical trials of drugs targeting brain Aβ. We found a positive association between the overall Aβ-PET SUVr and the disease duration sug gesting that the region-specific slow saturation of Aβ deposition continuously takes place as the disease progresses.Neurodegener Dis 2018;18:302 –309 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - March 7, 2019 Category: Neurology Source Type: research
Non-Invasive Brain Stimulation in Dementia: A Complex Network Story
Non-invasive brain stimulation (NIBS) is emerging as a promising rehabilitation tool for a number of neurodegenerative diseases. However, the therapeutic mechanisms of NIBS are not completely understood. In this review, we will summarize NIBS results in the context of brain imaging studies of functional connectivity and metabolites to gain insight into the possible mechanisms underlying recovery. We will briefly discuss how the clinical manifestations of common neurodegenerative disorders may be related with aberrant connectivity within large-scale neural networks. We will then focus on recent studies combining resting-sta...
Source: Neurodegenerative Diseases - January 31, 2019 Category: Neurology Source Type: research
The Role of MRI Biomarkers and Their Interactions with Cognitive Status and APOE ε4 in Nondemented Elderly Subjects
Conclusion: Atrophy of the hippocampal subfields may be a powerful biomarker for MCI in the Chinese population.Neurodegener Dis 2018;18:270 –280 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - January 23, 2019 Category: Neurology Source Type: research
Evaluation of D < sub > 1 < /sub > /D < sub > 5 < /sub > Partial Agonist PF-06412562 in Parkinson ’s Disease following Oral Administration
Conclusions: We report the first evidence of potential anti-parkinsonian efficacy of the oral selective D1/D5 partial agonist PF-06412562 without the significant acute changes in cardiovascular parameters reported with previous D1 agonists.Neurodegener Dis 2018;18:262 –269 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - November 20, 2018 Category: Neurology Source Type: research
Cerebrospinal Fluid Neurofilaments May Discriminate Upper Motor Neuron Syndromes: A Pilot Study
Conclusions: Despite some statistical instability of the results due to limitations in sample size, our study supports the role of CSF pNfH as a prognostic biomarker for motor neuron diseases presenting with UMN signs. A potential power to discriminate between ALS and other UMN syndromes at presentation, and between all of the examined MND and HC, has been detected for both CSF and serum pNfH.Neurodegener Dis 2018;18:255 –261 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - November 14, 2018 Category: Neurology Source Type: research
