The Precuneus – A Witness for Excessive Aβ Gathering in Alzheimer’s Disease Pathology

Conclusions: The voxel-wise semiquantitative analysis shows that the precuneus is a region with higher vulnerability to A β depositions when compared to other cortical regions in both MCI-AD and ADD subjects. We think that the precuneus is a promising PET-based outcome measure for clinical trials of drugs targeting brain Aβ. We found a positive association between the overall Aβ-PET SUVr and the disease duration sug gesting that the region-specific slow saturation of Aβ deposition continuously takes place as the disease progresses.Neurodegener Dis 2018;18:302 –309
Source: Neurodegenerative Diseases - Category: Neurology Source Type: research