Mutated Huntingtin Causes Testicular Pathology in Transgenic Minipig Boars
Conclusions: The sperm and testicular degeneration of TgHD boars is caused by gain-of-function of the highly expressed mtHtt.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - March 9, 2016 Category: Neurology Source Type: research
Pharmacological or Genetic Activation of Hsp70 Protects against Loss of Parkin Function
Mutations of parkin are a prevalent genetic contributor to familial Parkinson's disease (PD). As a key regulator of protein and mitochondrial homeostasis, parkin plays a pivotal role in maintaining dopaminergic neuronal survival. However, whereas Drosophila parkin null mutants exhibit prominent parkinsonian features, parkin-deficient mice generally lack an overt phenotype. Here, we found that the expression of Hsp70 along with several other members of the chaperone family is elevated in parkin null mice, suggesting a possible compensatory mechanism for the loss of parkin function in these mice that could have masked their ...
Source: Neurodegenerative Diseases - February 17, 2016 Category: Neurology Source Type: research
Population-Based Evidence that Survival in Amyotrophic Lateral Sclerosis Is Related to Weight Loss at Diagnosis
Conclusion: More than 50% of ALS patients experience a WL of more than 5% at the time of diagnosis. This finding highlights the need for randomized trials to evaluate the effect of nutritional interventions to improve ALS survival.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - February 11, 2016 Category: Neurology Source Type: research
Integration of Intention and Outcome for Moral Judgment in Frontotemporal Dementia: Brain Structural Signatures
Conclusions: Results suggest that moral judgment abnormalities in bvFTD are associated with impaired integration of intentions and outcomes, which depends on an extended brain network. In bvFTD, moral judgment seems to critically depend on areas beyond the VMPFC.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - February 10, 2016 Category: Neurology Source Type: research
Subject Index Vol. 16, No. 1-2, 2016
Neurodegener Dis 2016;16:126 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - January 30, 2016 Category: Neurology Source Type: research
Author Index Vol. 16, No. 1-2, 2016
Neurodegener Dis 2016;16:125 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - January 30, 2016 Category: Neurology Source Type: research
Title Page / Table of Contents
Neurodegener Dis 2016;16:1-4 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - January 30, 2016 Category: Neurology Source Type: research
Preface
Neurodegener Dis 2016;16:5 (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - January 30, 2016 Category: Neurology Source Type: research
Low Serum Vitamin D Levels May Contribute to Gastric Dysmotility in de novo Parkinson's Disease
Conclusions: Vitamin D status may be an independent factor for gastric dysmotility in PD. Although the underlying mechanism remains to be characterized, vitamin D status may play a role in the pathogenesis of delayed gastric emptying in drug-naive PD.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - January 12, 2016 Category: Neurology Source Type: research
BDNF Serum Levels with Respect to Multidimensional Assessment in Amyotrophic Lateral Sclerosis
Conclusion: BDNF serum levels might mark and possibly contribute in part to ALS phenotypic variability.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - January 12, 2016 Category: Neurology Source Type: research
Cerebral β-Amyloid Angiopathy Is Associated with Earlier Dementia Onset in Alzheimer's Disease
Conclusions: Our results suggest that CAA contributes to changes in early AD pathogenesis. This supports the idea that vascular change and neuritic plaque deposition are not just parallel processes but reflect additive pathological cascades that influence the course of clinical AD manifestation. Further inquiry into the role of CAA and its contribution to early cognitive change in AD is suggested.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - January 12, 2016 Category: Neurology Source Type: research
Measuring Global Brain Atrophy with the Brain Volume/Cerebrospinal Fluid Index: Normative Values, Cut-Offs and Clinical Associations
Background: Global brain atrophy is present in normal aging and different neurodegenerative disorders such as Alzheimer's disease (AD) and is becoming widely used to monitor disease progression. Summary: The brain volume/cerebrospinal fluid index (BV/CSF index) is validated in this study as a measurement of global brain atrophy. We tested the ability of the BV/CSF index to detect global brain atrophy, investigated the influence of confounders, provided normative values and cut-offs for mild, moderate and severe brain atrophy, and studied associations with different outcome variables. A total of 1,009 individuals were inclu...
Source: Neurodegenerative Diseases - December 18, 2015 Category: Neurology Source Type: research
Frontotemporal Dysfunction in Amyotrophic Lateral Sclerosis: A Discriminant Function Analysis
Conclusions: We stress the importance of discriminant function analysis in clinical neuropsychological assessment and argue that the proposed neuropsychological battery may be of clinical value, especially when the option of extensive and comprehensive neuropsychological testing is limited. The psychometric validity of an ALS-frontotemporal dementia diagnosis using neuropsychological tests is also discussed.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - December 15, 2015 Category: Neurology Source Type: research
Visual Assessment of Age-Related White Matter Hyperintensities Using FLAIR Images at 3 T: Inter- and Intra-Rater Agreement
Conclusion: Visual assessment of age-related white matter hyperintensities by radiologists using a visual scale on FLAIR sequence is reproducible. Differences in experience level do not influence readings. Visual scale use is thus justified in common practice.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - December 8, 2015 Category: Neurology Source Type: research
PET Radioligands Reveal the Basis of Dementia in Parkinson's Disease and Dementia with Lewy Bodies
Background: Effective therapies for dementia with Lewy bodies (DLB) and Parkinson's disease (PD) dementia will require accurate diagnosis and an understanding of the contribution of distinct molecular pathologies to these diseases. We seek to use imaging biomarkers to improve diagnostic accuracy and to clarify the contribution of molecular species to cognitive impairment in DLB and PD. Summary: We have performed cross-sectional and prospective cohort studies in subjects with DLB, PD with normal cognition, PD with mild cognitive impairment and PD with dementia, contrasted with Alzheimer's disease (AD) and healthy control su...
Source: Neurodegenerative Diseases - December 7, 2015 Category: Neurology Source Type: research
