Neurofilament Subunit L Levels in the Cerebrospinal Fluid and Serum of Patients with Amyotrophic Lateral Sclerosis

Conclusions: NF-L levels increased in CSF and serum of patients with ALS. NF-L may thus be a neurodegenerative biomarker for predicting ALS severity and progression, and the survival of patients with this disease.Neurodegener Dis
Source: Neurodegenerative Diseases - Category: Neurology Source Type: research

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This study extends the findings of prior reports indicating that lower doses of DATS mediate cell survival in part by inducing autophagy and activating the Nrf2/antioxidant response element pathway. PMID: 30317421 [PubMed - as supplied by publisher]
Source: Neurochemical Research - Category: Neuroscience Authors: Tags: Neurochem Res Source Type: research
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Source: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration - Category: Neurology Authors: Source Type: research
Publication date: Available online 25 September 2018Source: Egyptian Journal of AnaesthesiaAuthor(s): Bo-Ra Kim, Young-Bok Lee, Su-Jin Kim, Young-Wan KimAbstractAmyotrophic lateral sclerosis, which is also known as motor neuron disease, is a chronic neurodegenerative disease characterized by progressive muscular weakness, respiratory muscle disability, and eventual death. Previous epidemiologic studies have shown no association between cancer and amyotrophic lateral sclerosis. Colorectal cancer arising in patients with amyotrophic lateral sclerosis has rarely been reported. Here, we report a case involving rectal cancer ar...
Source: Egyptian Journal of Anaesthesia - Category: Anesthesiology Source Type: research
Publication date: Available online 2 October 2018Source: Neurophysiologie CliniqueAuthor(s): Farzad Fatehi, Aude-Marie Grapperon, Davood Fathi, Emilien Delmont, Shahram AttarianSummaryThe need for a valid biomarker for assessing disease progression and for use in clinical trials on amyotrophic lateral sclerosis (ALS) has stimulated the study of methods that could measure the number of motor units. Motor unit number index (MUNIX) is a newly developed neurophysiological technique that was demonstrated to have a good correlation with the number of motor units in a given muscle, even though it does not necessarily accurately e...
Source: Neurophysiologie Clinique - Category: Neuroscience Source Type: research
Publication date: Available online 29 September 2018Source: Neuroscience LettersAuthor(s): Shunya Yokota, Yui Kobatake, Yasuhiro Noda, Kohei Nakata, Osamu Yamato, Hideaki Hara, Hiroki Sakai, Hidetaka Nishida, Sadatohi Maeda, Hiroaki KamishinaAbstractCanine degenerative myelopathy (DM) is an adult-onset progressive and fatal neurodegenerative disorder. Superoxide dismutase 1 (SOD1) mutations have been reported in affected dogs and immunohistochemical analyses revealed the accumulation of mutant SOD1 (E40 K) in spinal neurons and astrocytes. Therefore, this disease is regarded as a unique spontaneous large-animal mode...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
AbstractThe fourteen cases of Hirayama disease (HD) are presented in this article. HD is seldom disease characterized by juvenile muscular atrophy of upper extremities and benign course. All cases were diagnosed in the Research Center of Neurology (Moscow, Russia) during the year 2015 –2017. Such methods as MRI (magnetic resonance imaging), EMG (electromyography), and NCS (nerve conduction studies) have been used to confirm diagnosis of HD. Transcranial magnetic stimulation was used to exclude upper motor neuron involvement in two cases. The original scale of neurological distu rbances in HD has been proposed by auth...
Source: Neurological Sciences - Category: Neurology Source Type: research
Conditions:   Amyotrophic Lateral Sclerosis;   Motor Neuron Disease Interventions:   Drug: CannTrust CBD Oil (capsule);   Drug: Placebo (capsule) Sponsors:   Gold Coast Hospital and Health Service;   CannTrust Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
acute;s-Ferrer V, Chumillas MJ, Sevilla T Abstract OBJECTIVE: To describe the fasciculation pattern in ALS and to analyse its clinical and pathophysiological significance. METHODS: Ultrasound of 19 muscles was performed in 44 patients with a recent diagnosis (
Source: Clinical Neurophysiology - Category: Neurology Authors: Tags: Clin Neurophysiol Source Type: research
Publication date: Available online 18 September 2018Source: Pharmacological ResearchAuthor(s): Yajuan Xiao, Chehade Karam, Jianxun Yi, Lin Zhang, Xuejun Li, Dosuk Yoon, Huan Wang, Kamal Dhakal, Paul Ramlow, Tian Yu, Zhaohui Mo, Jianjie Ma, Jingsong ZhouAbstractIn amyotrophic lateral sclerosis (ALS), mitochondrial dysfunction and oxidative stress form a vicious cycle that promotes neurodegeneration and muscle wasting. To quantify the disease-stage-dependent changes of mitochondrial function and their relationship to the generation of reactive oxygen species (ROS), we generated double transgenic mice (G93 A/cpYFP) tha...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Our objective was to quantify health service utilisation including monitoring and treatment of respiratory complications for adults with neuromuscular disease (NMD), identifying practice variation and adherence to guideline recommendations at a population level. We conducted a population-based longitudinal cohort study (2003–2015) of adults with NMD using hospital diagnostic and health insurance billing codes within administrative health databases. We identified 185 586 adults with NMD. Mean age 52 years, 59% female. 41 173 (22%) went to an emergency department for respiratory complications on average 1.6 times ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory clinical practice Original Articles: Neuromuscular disease Source Type: research
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