Interferon Lambda Family along with HTLV-1 Proviral Load, Tax, and HBZ Implicated in the Pathogenesis of Myelopathy/Tropical Spastic Paraparesis

HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic neuroinflammatory disease related to human T lymphotropic virus type 1 (HTLV-1) infection. Interferon type III (IFN- λ), which includes IL28, IL29, and IL28R, and affects the outcome of viral infections, might be complicated in the progression of HAM/TSP. Here, we investigated the host-virus interactions in the manifestation of HAM/TSP, using IL28B, IL29, IL28R, HTLV-1 Tax, HTLV-1 basic leucine zipper factor (HBZ ), and proviral load (PVL). The study groups consisted of 20 patients with HAM/TSP, 20 asymptomatic HTLV-1 carriers (ACs), and 20 healthy controls (HCs). The means of PVL, Tax, andHBZ gene expressions in the HAM/TSP group (p = 0.004, 0.006, and #x3c; 0.0001, respectively) were significantly higher than in the AC group. The comparison of IL28B, IL29, and IL28R expression in the HAM/TSP, AC, and HC groups revealed no significant difference between the first 2, but lower concentrations in the HCs (IL28B:p = 0.03, 0.01; IL29:p = 0.07, 0.01; and IL28R:p #x3c; 0.0001, respectively). In the HAM/TSP group, correlations were seen between Tax and HBZ (R = 0.61,p = 0.004) and between Tax and IL29 (R = 0.45,p = 0.04). Negative correlations were observed between Tax and IL28B (R = –0.49,p = 0.02) and between HBZ and IL28R (R = –0.43,p = 0.06). In the ACs, an inverse correlation was found between Tax and IL28B (R = –0.42,p = 0.06). These findings suggest that IL29, IL28B, and IL28R interfere in...

Source: Neurodegenerative Diseases - July 10, 2018 Category: Neurology Source Type: research