Co-utilization of glucose and xylose for the production of poly- β-hydroxybutyrate (PHB) by Sphingomonas sanxanigenens NX02
Poly- β-hydroxybutyrate (PHB), produced by a variety of microbial organisms, is a good substitute for petrochemically derived plastics due to its excellent properties such as biocompatibility and biodegradabili... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - August 27, 2023 Category: Microbiology Authors: Yue Ming, Guoqiang Li, Zhuangzhuang Shi, Xin Zhao, Yufei Zhao, Ge Gao, Ting Ma and Mengmeng Wu Tags: Research Source Type: research
Tuning transcription factor DegU for developing extracellular protease overproducer in Bacillus pumilus
Global transcription machinery engineering (gTME) is an effective approach employed in strain engineering to rewire gene expression and reshape cellular metabolic fluxes at the transcriptional level. (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - August 27, 2023 Category: Microbiology Authors: Chao-Ying Xie, Wen-Jin Li and Hong Feng Tags: Research Source Type: research
Antibacterial peptide PMAP-37(F34-R), expressed in Pichia pastoris, is effective against pathogenic bacteria and preserves plums
Recently, researchers have focused on the search for alternatives to conventional antibiotics. Antimicrobial peptides are small bioactive peptides that regulate immune activation and have antibacterial activit... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - August 27, 2023 Category: Microbiology Authors: Chunming Dong, Lijun Xu, Weitao Lu, Mengru Li, Rui Zhang, Yanyan Sun, Jian Liu and Xinlei Chu Tags: Research Source Type: research
Insight into de-regulation of amino acid feedback inhibition: a focus on structure analysis method
Regulation of amino acid ’s biosynthetic pathway is of significant importance to maintain homeostasis and cell functions. Amino acids regulate their biosynthetic pathway by end-product feedback inhibition of en... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - August 23, 2023 Category: Microbiology Authors: Sadia Naz, Pi Liu, Umar Farooq and Hongwu Ma Tags: Review Source Type: research
Expanding the genetic toolbox of Rhodotorula toruloides by identification and validation of six novel promoters induced or repressed under nitrogen starvation
The non-conventional yeast Rhodotorula toruloides is an emerging host organism in biotechnology by merit of its natural capacity to accumulate high levels of carotenoids and intracellular storage lipids from a va... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - August 19, 2023 Category: Microbiology Authors: Daniel P. Brink, Friederike Mierke, Joakim Norbeck, Verena Siewers and Thomas Andlid Tags: Research Source Type: research
The flavohaemoprotein hmp maintains redox homeostasis in response to reactive oxygen and nitrogen species in Corynebacterium glutamicum
During the production of L-arginine through high dissolved oxygen and nitrogen supply fermentation, the industrial workhorse Corynebacterium glutamicum is exposed to oxidative stress. This generates reactive oxyg... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - August 18, 2023 Category: Microbiology Authors: Ziqin Jiang, Jingyi Guan, Tingting Liu, Chunyu Shangguan, Meijuan Xu and Zhiming Rao Tags: Research Source Type: research
Development of a novel glycoengineering platform for the rapid production of conjugate vaccines
Conjugate vaccines produced either by chemical or biologically conjugation have been demonstrated to be safe and efficacious in protection against several deadly bacterial diseases. However, conjugate vaccine ... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - August 18, 2023 Category: Microbiology Authors: Sherif Abouelhadid, Elizabeth R. Atkins, Emily J. Kay, Ian J. Passmore, Simon J. North, Burhan Lehri, Paul Hitchen, Eirik Bakke, Mohammed Rahman, Janine T. Boss é, Yanwen Li, Vanessa S. Terra, Paul R. Langford, Anne Dell, Brendan W. Wren and Jon Cuccui Tags: Research Source Type: research
Heterologous production of the insecticidal pea seed albumin PA1 protein by Pichia pastoris and protein engineering to potentiate aphicidal activity via fusion to snowdrop lectin Galanthus nivalis agglutinin; GNA)
New bioinsecticides with novel modes of action are urgently needed to minimise the environmental and safety hazards associated with the use of synthetic chemical pesticides and to combat growing levels of pest... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - August 17, 2023 Category: Microbiology Authors: Jake S. De-Thier, Prashant Pyati, Jack Bell, Jennifer J. Readshaw, Adrian P. Brown and Elaine C. Fitches Tags: Research Source Type: research
Fused expression of Sm1-Chit42 proteins for synergistic mycoparasitic response of Trichoderma afroharzianum on Botrytis cinerea
Sm1 and Chit42 of Trichoderma have been universally confirmed as crucial biocontrol factors against pathogen infection through induced resistance and mycoparasitism, respectively. However, not enough work has bee... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - August 17, 2023 Category: Microbiology Authors: Hongyi Liu, Shaoqing Wang, Bo Lang, Yaqian Li, Xinhua Wang and Jie Chen Tags: Research Source Type: research
Mutation in yl-HOG1 represses the filament-to-yeast transition in the dimorphic yeast Yarrowia lipolytica
Yarrowia lipolytica is a dimorphic fungus, which switches from yeast to filament form in response to environmental conditions. For industrial purposes it is important to lock cells in the yeast or filamentous for... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - August 16, 2023 Category: Microbiology Authors: Dorota A. Rzechonek, Mateusz Szczepa ńczyk and Aleksandra M. Mirończuk Tags: Research Source Type: research
Rhizopus stolonifer biomass catalytic transesterification capability: optimization of cultivation conditions
Using fungal biomass for biocatalysis is a potential solution for the expensive cost of the use o enzymes. Production of fungal biomass with effective activity requires optimizing the cultivation conditions. (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - August 14, 2023 Category: Microbiology Authors: Nadeem I. Elhussieny, Heba A. El-Refai, Sayeda S. Mohamed, Yousseria M. Shetaia, Hala A. Amin and Gerd Kl öck Tags: Research Source Type: research
Impact of mixing insufficiencies on L-phenylalanine production with an Escherichia coli reporter strain in a novel two-compartment bioreactor
The omnipresence of population heterogeneity in industrial bioprocesses originates from prevailing dynamic bioprocess conditions, which promote differences in the expression of cellular characteristics. Despit... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - August 13, 2023 Category: Microbiology Authors: Manh Dat Hoang, Ingmar Polte, Lukas Frantzmann, Nikolas von den Eichen, Anna-Lena Heins and Dirk Weuster-Botz Tags: Research Source Type: research
Copper biosorption by Bacillus pumilus OQ931870 and Bacillus subtilis OQ931871 isolated from Wadi Nakheil, Red Sea, Egypt
Despite being necessary, copper is a toxic heavy metal that, at high concentrations, harms the life system. The parameters that affect the bioreduction and biosorption of copper are highly copper-resistant bac... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - August 12, 2023 Category: Microbiology Authors: Amal William Danial and Fatma Mohamed Dardir Tags: Research Source Type: research
Development of the thermophilic fungus Myceliophthora thermophila into glucoamylase hyperproduction system via the metabolic engineering using improved AsCas12a variants
Glucoamylase is an important enzyme for starch saccharification in the food and biofuel industries and mainly produced from mesophilic fungi such as Aspergillus and Rhizopus species. Enzymes produced from thermop... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - August 11, 2023 Category: Microbiology Authors: Zhijian Zhu, Manyu Zhang, Dandan Liu, Defei Liu, Tao Sun, Yujing Yang, Jiacheng Dong, Huanhuan Zhai, Wenliang Sun, Qian Liu and Chaoguang Tian Tags: Research Source Type: research
Conversion of methionine biosynthesis in Escherichia coli from trans- to direct-sulfurylation enhances extracellular methionine levels
Methionine is an essential amino acid in mammals and a precursor for vital metabolites required for the survival of all organisms. Consequently, its inclusion is required in diverse applications, such as food,... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - August 11, 2023 Category: Microbiology Authors: Nadya Gruzdev, Yael Hacham, Hadar Haviv, Inbar Stern, Matan Gabay, Itai Bloch, Rachel Amir, Maayan Gal and Itamar Yadid Tags: Research Source Type: research
