Discovery and overproduction of novel highly bioactive pamamycins through transcriptional engineering of the biosynthetic gene cluster
Pamamycins are a family of highly bioactive macrodiolide polyketides produced by Streptomyces alboniger as a complex mixture of derivatives with molecular weights ranging from 579 to 705 Daltons. The large deriva... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - November 14, 2023 Category: Microbiology Authors: Nikolas Eckert, Yuriy Rebets, Lilya Horbal, Josef Zapp, Jennifer Herrmann, Tobias Busche, Rolf M üller, Jörn Kalinowski and Andriy Luzhetskyy Tags: Research Source Type: research
Effect of minocycline, methyl prednisolone, or combination treatment on the colonic bacterial population in a state of colonic inflammation using the murine dextran sulfate sodium model
Several reports demonstrated anti-inflammatory properties of minocycline in various inflammatory disorders including colitis. We have experimental evidence suggesting synergistic anti-inflammatory effect of mi... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - November 10, 2023 Category: Microbiology Authors: Maitham A. Khajah and Sanaa Hawai Tags: Research Source Type: research
Induction of the CtsR regulon improves Xylanase production in Bacillus subtilis
The bacterium Bacillus subtilis is extensively used for the commercial production of enzymes due to its efficient protein secretion capacity. However, the efficiency of secretion varies greatly between enzymes, a... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - November 9, 2023 Category: Microbiology Authors: Biwen Wang, Frans van der Kloet and Leendert W. Hamoen Tags: Research Source Type: research
Construction of synthetic anti-fouling consortia: fouling control effects and polysaccharide degradation mechanisms
The physical states and chemical components of bulk sludge determine the occurrence and development of membrane fouling in membrane bioreactors. Thus, regulation of sludge suspensions can provide new strategie... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - November 8, 2023 Category: Microbiology Authors: Ji Qi, Qicheng Zhou, Danlei Huang, Zhong Yu and Fangang Meng Tags: Research Source Type: research
Identification and statistical optimization of a novel alginate polymer extracted from newly isolated Synechocystis algini MNE ON864447 with antibacterial activity
Cyanobacteria are a potential source of promising secondary metabolites with different biological activities, including antibacterial, antiviral, antifungal, antiprotozoal, and anticancer activities. To combat... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - November 7, 2023 Category: Microbiology Authors: Mabroka H. Saad, Nagwa M. Sidkey and Esmail M. El-Fakharany Tags: Research Source Type: research
An exploratory in silico comparison of open-source codon harmonization tools
Not changing the native constitution of genes prior to their expression by a heterologous host can affect the amount of proteins synthesized as well as their folding, hampering their activity and even cell via... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - November 6, 2023 Category: Microbiology Authors: Thomas Willems, Wim Hectors, Jeltien Rombaut, Anne-Sofie De Rop, Stijn Goegebeur, Tom Delmulle, Maarten L. De Mol, Sofie L. De Maeseneire and Wim K. Soetaert Tags: Research Source Type: research
Mycosynthesis of silver nanoparticles from endophytic Aspergillus flavipes AUMC 15772: ovat-statistical optimization, characterization and biological activities
Mycosynthesis of silver nanoparticles (SNPs) offers a safe, eco-friendly, and promising alternative technique for large-scale manufacturing. Our study might be the first report that uses mycelial filtrate of a... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - November 6, 2023 Category: Microbiology Authors: Nessma A. EL-Zawawy, Alaa M. Abou-Zeid, Doha M. Beltagy, Nada H. Hantera and Hoda S. Nouh Tags: Research Source Type: research
The extracellular polysaccharide inhibit porcine epidemic diarrhea virus with extract and gene editing Lacticaseibacillus
Lacticaseibacillus is one of the predominant microorganisms in gut from human and animal, and the lacticaseibacillus have effective applications against the viral diarrhea of piglets in the farm. However, the fun... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - November 4, 2023 Category: Microbiology Authors: Shaojun Chen, Zida Nai, Ziliang Qin, Gang Li, Xinmiao He, Wentao Wang, Yaguang Tian, Di Liu and Xinpeng Jiang Tags: Research Source Type: research
Plants and endophytes interaction: a “secret wedlock” for sustainable biosynthesis of pharmaceutically important secondary metabolites
Many plants possess immense pharmacological properties because of the presence of various therapeutic bioactive secondary metabolites that are of great importance in many pharmaceutical industries. Therefore, ... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - November 4, 2023 Category: Microbiology Authors: Poonam Kumari, Nikky Deepa, Prabodh Kumar Trivedi, Brajesh K. Singh, Vaibhav Srivastava and Akanksha Singh Tags: Review Source Type: research
Application of whole-cell biosensors for analysis and improvement of L- and D-lactic acid fermentation by Lactobacillus spp. from the waste of glucose syrup production
Lactic acid is one of the most important organic acids, with various applications in the food, beverage, pharmaceutical, cosmetic, and chemical industries. Optically pure forms of L- and D-lactic acid produced... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - October 30, 2023 Category: Microbiology Authors: Ernesta Augustiniene, Ilona Jonuskiene, Jurgita Kailiuviene, Edita Mazoniene, Kestutis Baltakys and Naglis Malys Tags: Research Source Type: research
A novel protein purification scheme based on salt inducible self-assembling peptides
Protein purification remains a critical need for biosciences and biotechnology. It frequently requires multiple rounds of chromatographic steps that are expensive and time-consuming. Our lab previously reporte... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - October 30, 2023 Category: Microbiology Authors: Guang Zeng, Yinzhen Zheng, Ya Xiang, Run Liu, Xiaofeng Yang and Zhanglin Lin Tags: Research Source Type: research
Mechanism of furfural toxicity and metabolic strategies to engineer tolerance in microbial strains
Lignocellulosic biomass represents a carbon neutral cheap and versatile source of carbon which can be converted to biofuels. A pretreatment step is frequently used to make the lignocellulosic carbon bioavailab... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - October 28, 2023 Category: Microbiology Authors: S. Bilal Jilani and Daniel G. Olson Tags: Review Source Type: research
Systems biology of industrial oxytetracycline production in Streptomyces rimosus: the secrets of a mutagenized hyperproducer
Oxytetracycline which is derived from Streptomyces rimosus, inhibits a wide range of bacteria and is industrially important. The underlying biosynthetic processes are complex and hinder rational engineering, so i... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - October 28, 2023 Category: Microbiology Authors: Selma Beganovic, Christian R ückert-Reed, Hilda Sucipto, Wei Shu, Lars Gläser, Thomas Patschkowski, Ben Struck, Jörn Kalinowski, Andriy Luzhetskyy and Christoph Wittmann Tags: Research Source Type: research
Adaptive laboratory evolution of Rhodococcus rhodochrous DSM6263 for chlorophenol degradation under hypersaline condition
Normally, a salt amount greater than 3.5% (w/v) is defined as hypersaline. Large amounts of hypersaline wastewater containing organic pollutants need to be treated before it can be discharged into the environm... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - October 26, 2023 Category: Microbiology Authors: Jie Zheng, Zhengzhi Zhang, Juan An, Yubin Xue and Bo Yu Tags: Research Source Type: research
Systematic engineering pinpoints a versatile strategy for the expression of functional cytochrome P450 enzymes in Escherichia coli cell factories
Production of plant secondary metabolites in engineered microorganisms provides a scalable and sustainable alternative to their sourcing from nature or through chemical synthesis. However, the biosynthesis of ... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - October 25, 2023 Category: Microbiology Authors: Michal Poborsky, Christoph Crocoll, Mohammed Saddik Motawie and Barbara Ann Halkier Tags: Research Source Type: research
