Three new LmbU targets outside lmb cluster inhibit lincomycin biosynthesis in Streptomyces lincolnensis
Antibiotics biosynthesis is usually regulated by the cluster-situated regulatory gene(s) (CSRG(s)), which directly regulate the genes within the corresponding biosynthetic gene cluster (BGC). Previously, we ha... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - January 3, 2024 Category: Microbiology Authors: Yue Mao, Xianyan Zhang, Tianyu Zhou, Bingbing Hou, Jiang Ye, Haizhen Wu, Ruida Wang and Huizhan Zhang Tags: Research Source Type: research
Engineering yeast with a light-driven proton pump system in the vacuolar membrane
The supply of ATP is a limiting factor for cellular metabolism. Therefore, cell factories require a sufficient ATP supply to drive metabolism for efficient bioproduction. In the current study, a light-driven p... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - January 3, 2024 Category: Microbiology Authors: Kaoru M. Daicho, Yoko Hirono-Hara, Hiroshi Kikukawa, Kentaro Tamura and Kiyotaka Y. Hara Tags: Research Source Type: research
Development of a genetic engineering toolbox for syngas-utilizing acetogen Clostridium sp. AWRP
Clostridium sp. AWRP (AWRP) is a novel acetogenic bacterium isolated under high partial pressure of carbon monoxide (CO) and can be one of promising candidates for alcohol production from carbon oxides. Compared ... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - January 3, 2024 Category: Microbiology Authors: Hae Jun Kwon, Joungmin Lee, Soo Jae Kwon and Hyun Sook Lee Tags: Research Source Type: research
Methanol bioconversion into C3, C4, and C5 platform chemicals by the yeast Ogataea polymorpha
One carbon (C1) molecules such as methanol have the potential to become sustainable feedstocks for biotechnological processes, as they can be derived from CO2 and green hydrogen, without the need for arable land.... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - January 3, 2024 Category: Microbiology Authors: Katrin Wefelmeier, Simone Schmitz, Benjamin Jonas K östers, Ulf Winfried Liebal and Lars Mathias Blank Tags: Research Source Type: research
Correction: Plants and endophytes interaction: a “secret wedlock” for sustainable biosynthesis of pharmaceutically important secondary metabolites
(Source: Microbial Cell Factories)
Source: Microbial Cell Factories - January 2, 2024 Category: Microbiology Authors: Poonam Kumari, Nikky Deepa, Prabodh Kumar Trivedi, Brajesh K. Singh, Vaibhav Srivastava and Akanksha Singh Tags: Correction Source Type: research
From waste to health-supporting molecules: biosynthesis of natural products from lignin-, plastic- and seaweed-based monomers using metabolically engineered Streptomyces lividans
Transforming waste and nonfood materials into bulk biofuels and chemicals represents a major stride in creating a sustainable bioindustry to optimize the use of resources while reducing environmental footprint... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - December 19, 2023 Category: Microbiology Authors: Kyoyoung Seo, Wei Shu, Christian R ückert-Reed, Patrick Gerlinger, Tobias J. Erb, Jörn Kalinowski and Christoph Wittmann Tags: Research Source Type: research
Raman spectroscopy online monitoring of biomass production, intracellular metabolites and carbon substrates during submerged fermentation of oleaginous and carotenogenic microorganisms
Monitoring and control of both growth media and microbial biomass is extremely important for the development of economical bioprocesses. Unfortunately, process monitoring is still dependent on a limited number... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - December 18, 2023 Category: Microbiology Authors: Simona Dzurendova, Pernille Margrethe Olsen, Dana Byrtusov á, Valeria Tafintseva, Volha Shapaval, Svein Jarle Horn, Achim Kohler, Martin Szotkowski, Ivana Marova and Boris Zimmermann Tags: Research Source Type: research
Human super antibody to viral RNA-dependent RNA polymerase produced by a modified Sortase self-cleave-bacteria surface display system
RNA-dependent RNA polymerase (RdRp) is a good target of anti-RNA virus agents; not only it is pivotal for the RNA virus replication cycle and highly conserved among RNA viruses across different families, but a... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - December 18, 2023 Category: Microbiology Authors: Kantaphon Glab-ampai, Kodchakorn Mahasongkram, Monrat Chulanetra, Thanatsaran Saenlom, Kanyarat Thueng-in, Nitat Sookrung and Wanpen Chaicumpa Tags: Research Source Type: research
A supernumerary synthetic chromosome in Komagataella phaffii as a repository for extraneous genetic material
Komagataella phaffii (Pichia pastoris) is a methylotrophic commercially important non-conventional species of yeast that grows in a fermentor to exceptionally high densities on simple media and secretes recombina... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - December 16, 2023 Category: Microbiology Authors: Dariusz Abramczyk, Maria del Carmen Sanchez Olmos, Adan Andres Ramirez Rojas, Daniel Schindler, Daniel Robertson, Stephen McColm, Adele L. Marston and Paul N. Barlow Tags: Research Source Type: research
Electricity generation and oxidoreductase potential during dye discoloration by laccase-producing Ganoderma gibbosum in fungal fuel cell
Color chemicals contaminate pure water constantly discharged from different points and non-point sources. Physical and chemical techniques have certain limitations and complexities for bioenergy production, wh... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - December 14, 2023 Category: Microbiology Authors: Aisha Umar, Islem Abid, Mohammed Antar, Laurent Dufoss é, Lobna Hajji-Hedfi, Mohamed S. Elshikh, Abeer El Shahawy and Ahmed M. Abdel-Azeem Tags: Research Source Type: research
PAS domain containing regulator SLCG_7083 involved in morphological development and glucose utilization in Streptomyces lincolnensis
Streptomyces lincolnensis is well known for producing the clinically important antimicrobial agent lincomycin. The synthetic and regulatory mechanisms on lincomycin biosynthesis have been deeply explored in recen... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - December 13, 2023 Category: Microbiology Authors: Chun-Yan Lin, Yixian Ru, Yanchao Jin, Qi Lin and Guang-Rong Zhao Tags: Research Source Type: research
Beneficial effects of GABA-producing potential probiotic Limosilactobacillus fermentum L18 of human origin on intestinal permeability and human gut microbiota
Gamma-aminobutyric acid (GABA) is a non-protein amino acid with neuroinhibitory, antidiabetic, and antihypertensive properties and is used as a drug for treating anxiety and depression. Some strains of lactoba... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - December 12, 2023 Category: Microbiology Authors: Sumanpreet Kaur, Preeti Sharma, Melinda J. Mayer, Saskia Neuert, Arjan Narbad and Sukhraj Kaur Tags: Research Source Type: research
New insights into the dihydro-mureidomycin biosynthesis controlled by two unusual proteins in Streptomyces roseosporus
Uridyl peptide compounds are renowned as a subclass of nucleoside antibiotics for their highly specific antibacterial activity against Gram-negative bacteria and the unique target of action. We previously acti... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - December 12, 2023 Category: Microbiology Authors: Ning Liu, Yang Xu, Fei Shang, Huiying Sun, Xiang Liu, Ying Huang, Huarong Tan and Jihui Zhang Tags: Research Source Type: research
The nutritional composition and cell size of microbial biomass for food applications are defined by the growth conditions
It is increasingly recognized that conventional food production systems are not able to meet the globally increasing protein needs, resulting in overexploitation and depletion of resources, and environmental d... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - December 11, 2023 Category: Microbiology Authors: Myrsini Sakarika, Frederiek-Maarten Kerckhof, Lotte Van Peteghem, Alexandra Pereira, Tim Van Den Bossche, Robbin Bouwmeester, Ralf Gabriels, Delphi Van Haver, Barbara Ul čar, Lennart Martens, Francis Impens, Nico Boon, Ramon Ganigué and Korneel Rabaey Tags: Research Source Type: research
Efficient de novo production of bioactive cordycepin by Aspergillus oryzae using a food-grade expression platform
Cordycepin (3 ′-deoxyadenosine) is an important bioactive compound in medical and healthcare markets. The drawbacks of commercial cordycepin production using Cordyceps spp. include long cultivation periods and low... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - December 9, 2023 Category: Microbiology Authors: Sukanya Jeennor, Jutamas Anantayanon, Sarocha Panchanawaporn, Chanikul Chutrakul, Wanwipa Vongsangnak and Kobkul Laoteng Tags: Research Source Type: research
