Untargeted metabolomic, and proteomic analysis identifies metabolic biomarkers and pathway alterations in individuals with 22q11.2 deletion syndrome
ConclusionTo our knowledge, this is the first report on plasma metabolic and proteomic profiling and on the identification of unique biomarkers in 22q11.2DS. These findings may suggest the potential role of the identified metabolites and proteins as biomarkers for the onset of comorbid conditions in 22q11.2DS. Ultimately, the altered protein pathways in 22q11.2DS may provide insights of the biological mechanisms underlying the neurodevelopmental phenotype and may provide missing molecular outcome measures in future clinical trials to assess early-diagnosis treatment and the efficacy of response to targeted treatment. (Source: Metabolomics)
Source: Metabolomics - February 28, 2024 Category: Biology Source Type: research
Discovery of metabolite biomarkers for odontogenic keratocysts
ConclusionThis study is the first to investigate the metabolic characteristics and potential metabolic biomarkers in the serum of OKC patients using GC ‒MS. Our study provides further evidence to explore the pathogenesis of OKC. (Source: Metabolomics)
Source: Metabolomics - February 28, 2024 Category: Biology Source Type: research
Identification of glucose-independent and reversible metabolic pathways associated with anti-proliferative effect of metformin in liver cancer cells
ConclusionsThe derangement of multiple glucose-independent metabolic pathways, which are often upregulated in therapy-resistant cancer, and concomitantcMyc downregulation coordinately contribute to the anti-proliferative effect of metformin in liver cancer cells. These are reversible and may influence its therapeutic utility. (Source: Metabolomics)
Source: Metabolomics - February 27, 2024 Category: Biology Source Type: research
Investigation into the role of phenolic compounds in the protection of citrus against Phyllosticta citricarpa
ConclusionNaringin, a major candidate biomarker was able to inhibit the growth of the pathogen at 10 000 ppm. (Source: Metabolomics)
Source: Metabolomics - February 26, 2024 Category: Biology Source Type: research
Associations of the placental metabolome with immune maturation up to one year of age in the Swedish NICE-cohort
ConclusionOur results indicate that metabolomic measurements of the placenta may not effectively recognize metabolites important for immune maturation. (Source: Metabolomics)
Source: Metabolomics - February 26, 2024 Category: Biology Source Type: research
Investigation into the role of phenolic compounds in the protection of citrus against Phyllosticta citricarpa
ConclusionNaringin, a major candidate biomarker was able to inhibit the growth of the pathogen at 10 000 ppm. (Source: Metabolomics)
Source: Metabolomics - February 26, 2024 Category: Biology Source Type: research
Associations of the placental metabolome with immune maturation up to one year of age in the Swedish NICE-cohort
ConclusionOur results indicate that metabolomic measurements of the placenta may not effectively recognize metabolites important for immune maturation. (Source: Metabolomics)
Source: Metabolomics - February 26, 2024 Category: Biology Source Type: research
Metabolomics approach for phenolic compounds profiling of soursop (Annona muricata L.) fruit during postharvest storage
ConclusionsHere, we show that the stage of ripening has a significant effect on the phenolic content, highlighting the point of cut (D0) and the onset of senescence (D5). The findings of this study provide new insights into the soursop fruit quality and may contribute to the identification of metabolic markers for its storage. (Source: Metabolomics)
Source: Metabolomics - February 25, 2024 Category: Biology Source Type: research
Toxicometabolomics-based cardiotoxicity evaluation of Thiazolidinedione exposure in human-derived cardiomyocytes
ConclusionThese findings demonstrate the utility of toxicometabolomics in elaborating on mechanisms of drug toxicity and identifying potential biomarkers, thus encouraging its application in the toxicological sciences. (245 words) (Source: Metabolomics)
Source: Metabolomics - February 23, 2024 Category: Biology Source Type: research
First comprehensive untargeted metabolomics study of suramin-treated Trypanosoma brucei: an integrated data analysis workflow from multifactor data modelling to functional analysis
ConclusionThrough the integration of LC –MS and NMR techniques coupled with advanced statistical analyses, this study identifies distinctive metabolic signatures and pathways associated with suramin treatment inT. brucei. These findings contribute to a deeper understanding of the pharmacological impact of suramin and have the potential to inform the development of more efficacious therapeutic strategies against African trypanosomiasis. (Source: Metabolomics)
Source: Metabolomics - February 23, 2024 Category: Biology Source Type: research
Toxicometabolomics-based cardiotoxicity evaluation of Thiazolidinedione exposure in human-derived cardiomyocytes
ConclusionThese findings demonstrate the utility of toxicometabolomics in elaborating on mechanisms of drug toxicity and identifying potential biomarkers, thus encouraging its application in the toxicological sciences. (245 words) (Source: Metabolomics)
Source: Metabolomics - February 23, 2024 Category: Biology Source Type: research
First comprehensive untargeted metabolomics study of suramin-treated Trypanosoma brucei: an integrated data analysis workflow from multifactor data modelling to functional analysis
ConclusionThrough the integration of LC –MS and NMR techniques coupled with advanced statistical analyses, this study identifies distinctive metabolic signatures and pathways associated with suramin treatment inT. brucei. These findings contribute to a deeper understanding of the pharmacological impact of suramin and have the potential to inform the development of more efficacious therapeutic strategies against African trypanosomiasis. (Source: Metabolomics)
Source: Metabolomics - February 23, 2024 Category: Biology Source Type: research
Exploration of differential responses to FODMAPs and gluten in people with irritable bowel syndrome- a double-blind randomized cross-over challenge study
ConclusionDifferential IBS responses to FODMAPs or gluten exposures could not be explained from clinical and molecular data despite extensive exploration with different data analytical approaches. The trial is registered atwww.clinicaltrials.gov as NCT03653689 31/08/2018. (Source: Metabolomics)
Source: Metabolomics - February 12, 2024 Category: Biology Source Type: research
