Gut metabolic changes during pregnancy reveal the importance of gastrointestinal region in sample collection
ConclusionsThe regional variation observed in the gut metabolome are likely due to the microbial and physiological differences between the different parts of the intestines. Additionally, pregnancy impacts the fecal metabolome, which may be due to evolving needs of both the dam and fetus. (Source: Metabolomics)
Source: Metabolomics - March 9, 2024 Category: Biology Source Type: research
Clinical advances in analytical profiling of signature lipids: implications for severe non-communicable and neurodegenerative diseases
AbstractBackgroundLipids play key roles in numerous biological processes, including energy storage, cell membrane structure, signaling, immune responses, and homeostasis, making lipidomics a vital branch of metabolomics that analyzes and characterizes a wide range of lipid classes. Addressing the complex etiology, age-related risk, progression, inflammation, and research overlap in conditions like Alzheimer's Disease, Parkinson’s Disease, Cardiovascular Diseases, and Cancer poses significant challenges in the quest for effective therapeutic targets, improved diagnostic markers, and advanced treatments. Mass spectrometr...
Source: Metabolomics - March 8, 2024 Category: Biology Source Type: research
Circulating N-lactoyl-amino acids and N-formyl-methionine reflect mitochondrial dysfunction and predict mortality in septic shock
ConclusionFuture studies which validate the measurement of lac-AAs and f-Met in conjunction with lactate could define a sepsis subtype characterized by mitochondrial dysfunction. (Source: Metabolomics)
Source: Metabolomics - March 6, 2024 Category: Biology Source Type: research
Longitudinal metabolite profiling of Streptococcus pneumoniae-associated community-acquired pneumonia
ConclusionThe identified metabolites may provide insight into biological mechanisms underlying disease severity and may be of interest for exploration as potential treatment response monitoring biomarker. (Source: Metabolomics)
Source: Metabolomics - March 5, 2024 Category: Biology Source Type: research
Dietary habits and plasma lipid concentrations in a general Japanese population
ConclusionThis study provides insight into the dietary impact on plasma lipid concentration in a Japanese population. (Source: Metabolomics)
Source: Metabolomics - March 5, 2024 Category: Biology Source Type: research
Longitudinal metabolite profiling of Streptococcus pneumoniae-associated community-acquired pneumonia
ConclusionThe identified metabolites may provide insight into biological mechanisms underlying disease severity and may be of interest for exploration as potential treatment response monitoring biomarker. (Source: Metabolomics)
Source: Metabolomics - March 5, 2024 Category: Biology Source Type: research
Dietary habits and plasma lipid concentrations in a general Japanese population
ConclusionThis study provides insight into the dietary impact on plasma lipid concentration in a Japanese population. (Source: Metabolomics)
Source: Metabolomics - March 5, 2024 Category: Biology Source Type: research
An exploratory investigation of the CSF metabolic profile of HIV in a South African paediatric cohort using GCxGC-TOF/MS
ConclusionsThis study provided valuable insights on the impact of HIV on metabolic pathways, including damage to the gut and blood –brain barrier, disruption of bioenergetics processes, gliosis, and a potential marker for antiretroviral therapy. Nevertheless, the study recognized certain constraints, notably a limited sample size and the absence of a validation cohort. Despite these limitations, the rarity of the study’s fo cus on paediatric HIV research underscores the significance and unique contributions of its findings. (Source: Metabolomics)
Source: Metabolomics - March 1, 2024 Category: Biology Source Type: research
Disrupted Tuzzerella abundance and impaired l-glutamine levels induce Treg accumulation in ovarian endometriosis: a comprehensive multi-omics analysis
ConclusionIn this study, we found a clear multi-omics pathway alteration, “Tuzzerella (microbe) —l-Glutamine (metabolite) —C7 (protein),” which affects the infiltration of Tregs in endometriotic lesions. Our findings provide insights into endometriosis classification and personalized treatment strategies based on microbial structures.Graphical abstract (Source: Metabolomics)
Source: Metabolomics - February 29, 2024 Category: Biology Source Type: research
Untargeted metabolomic, and proteomic analysis identifies metabolic biomarkers and pathway alterations in individuals with 22q11.2 deletion syndrome
ConclusionTo our knowledge, this is the first report on plasma metabolic and proteomic profiling and on the identification of unique biomarkers in 22q11.2DS. These findings may suggest the potential role of the identified metabolites and proteins as biomarkers for the onset of comorbid conditions in 22q11.2DS. Ultimately, the altered protein pathways in 22q11.2DS may provide insights of the biological mechanisms underlying the neurodevelopmental phenotype and may provide missing molecular outcome measures in future clinical trials to assess early-diagnosis treatment and the efficacy of response to targeted treatment. (Source: Metabolomics)
Source: Metabolomics - February 28, 2024 Category: Biology Source Type: research
Discovery of metabolite biomarkers for odontogenic keratocysts
ConclusionThis study is the first to investigate the metabolic characteristics and potential metabolic biomarkers in the serum of OKC patients using GC ‒MS. Our study provides further evidence to explore the pathogenesis of OKC. (Source: Metabolomics)
Source: Metabolomics - February 28, 2024 Category: Biology Source Type: research
