Metabolomics of head and neck cancer in biofluids: an integrative systematic review
ConclusionThe present work highlights utility of metabolite-based biomarkers for risk assessment, early detection, and prognostication of HNC, as well as facilitates incorporation of available metabolomics studies into multi-omics data integration and big data analytics for personalized health. (Source: Metabolomics)
Source: Metabolomics - August 29, 2023 Category: Biology Source Type: research
Identification of potential salivary biomarkers for Sj ögren’s syndrome with an untargeted metabolomic approach
This study aims to identify metabolites that could be used as biomarkers for SS.MethodsUsing the software called XCMS online, the salivary metabolic profiles obtained with liquid chromatography coupled to high-resolution mass spectrometry for 18 female SS patients were compared to those obtained for 22 age-matched female healthy controls.Results and conclusionA total of 91 metabolites showed differential expression in SS patients. A putative identification was proposed with the use of a database for 37 of these metabolites and, of these, 16 identifications were confirmed. Given the identified metabolites, some important me...
Source: Metabolomics - August 27, 2023 Category: Biology Source Type: research
Light effects on Lasiodiplodia theobromae metabolome cultured in vitro
AbstractIntroductionThe present work identified and compared intracellular metabolites and metabolic networks in mycelial cultures ofLasiodiplodia theobromae grown under 12 natural light and 24 hours ’ dark using a1 H NMR-based metabolomics approach.Materials and methods Fungal cultures were grown in potato dextrose media, and metabolites were extracted by sonication with sodium phosphate-buffered saline (pH = 6.0, 10% D2O, 0.1 mM TSP) from mycelium samples collected every week over four weeks.ResultsMultivariate analyses revealed that the light exposure group showed a positive correlation within beta-hydroxybutyra...
Source: Metabolomics - August 14, 2023 Category: Biology Source Type: research
Optimization of fecal sample homogenization for untargeted metabolomics
ConclusionsA comprehensive and systematical evaluation of various fecal matter homogenization conditions provides a profound understanding for the effects of different homogenization methods. Our findings would be beneficial to assist with standardization of fecal sample homogenization protocol. (Source: Metabolomics)
Source: Metabolomics - August 11, 2023 Category: Biology Source Type: research
Plasma metabolome identifies potential biomarkers of gastric precancerous lesions and gastric cancer risk
ConclusionIn our study, 9 defined metabolites might serve as meaningful biomarkers for identifying the high-risk population of GPL and GC, possibly enhancing the prevention and control of GPL and GC. (Source: Metabolomics)
Source: Metabolomics - August 10, 2023 Category: Biology Source Type: research
Methods for estimating insulin resistance from untargeted metabolomics data
ConclusionsWe have developed a method for estimating insulin resistance with metabolomics data that has the potential for application to a wide range of biomedical studies and conditions. (Source: Metabolomics)
Source: Metabolomics - August 9, 2023 Category: Biology Source Type: research
Quantitative trait loci mapping of polyphenol metabolites from a ‘Latham’ x ‘Glen Moy’ red raspberry (Rubus idaeus L) cross
ConclusionThe identification of robust QTLs for key polyphenols in raspberry provides great potential for marker-assisted breeding for improved levels of potentially health beneficial components. (Source: Metabolomics)
Source: Metabolomics - August 8, 2023 Category: Biology Source Type: research
Non-target ROIMCR LC –MS analysis of the disruptive effects of TBT over time on the lipidomics of Daphnia magna
ConclusionThe proposed non-targeted LC –MS lipidomics approach resulted to be a powerful tool to investigate the effects of the two factors on theDaphnia magna lipidome using chemometric methods based on bilinear and trilinear factor decomposition models, according to the type of interaction between the design factors. (Source: Metabolomics)
Source: Metabolomics - August 7, 2023 Category: Biology Source Type: research
