The relative abundance of fecal bacterial species belonging to the Firmicutes and Bacteroidetes phyla is related to plasma levels of bile acids in young adults
ConclusionsThe relative abundance of specific fecal bacteria species is associated with plasma levels of BA in young adults. However, further investigations are required to validate whether the composition of the gut microbiota can regulate the plasma concentrations of BA in humans. (Source: Metabolomics)
Source: Metabolomics - June 6, 2023 Category: Biology Source Type: research
Low-polarity untargeted metabolomic profiling as a tool to gain insight into seminal fluid
ConclusionA number of metabolites involved in sexual development and function, signaling, and energy metabolism were highlighted as being distinctive of samples coming from either group, proving untargeted metabolomics as a promising tool to better understand the pathophysiological processes responsible for male fertility impairment. (Source: Metabolomics)
Source: Metabolomics - June 5, 2023 Category: Biology Source Type: research
A comparative metabolomics investigation of flavonoid variation in faba bean flowers
ConclusionAnalysis of the different colored faba bean flowers confirmed that the color variation between the flowers was mainly controlled by anthocyanins in brown, red and purple-red flowers. Of the other flavonoids, multiglycosylated kaempferols were abundant in white and brown flowers, monoglycosylated kaempferols were common in red and purple-red flowers, and quercetin and apigenin glycosides were abundant co-pigments in purple-red flowers. (Source: Metabolomics)
Source: Metabolomics - May 30, 2023 Category: Biology Source Type: research
The time elapsed between assessments of blood metabolome and live weight affects associations between the abundance of metabolites and growth rate in beef cattle
ConclusionsDepending on the variable to be explored, rapid changes in cattle metabolome may not be reflected in correlations if they are not assessed close in time. Our findings suggest that LWC should be measured for a period shorter than 28 days before the metabolome assessment as the number of significant associations decreases when LWC is measured for longer periods. (Source: Metabolomics)
Source: Metabolomics - May 15, 2023 Category: Biology Source Type: research
Discovery of novel metabolic signatures for early identification of women at risk of developing gestational hypertension
ConclusionThe present study is the first of its kind to identify significantly altered metabolites that have the potential to discriminate between women at risk of developing GH and normotensive women across three trimesters of pregnancy. This opens up the possibility of exploring these metabolites as potential early predictive markers of GH. (Source: Metabolomics)
Source: Metabolomics - May 8, 2023 Category: Biology Source Type: research
Application of machine learning tools and integrated OMICS for screening and diagnosis of inborn errors of metabolism
ConclusionCalibrated cut-offs of different analytes in TMS and machine learning-based establishment of disease-specific thresholds of these markers through integrated OMICS have helped in improved differential diagnosis with significant reduction of the false positivity and false negativity rates. (Source: Metabolomics)
Source: Metabolomics - May 3, 2023 Category: Biology Source Type: research
Chemical and cytotoxicity profiles of 11 pink pepper (Schinus spp.) samples via non-targeted hyphenated high-performance thin-layer chromatography
ConclusionThe developed non-targeted hyphenated RP-HPTLC –UV/Vis/FLD–bioluminescent cytotoxicity bioassay–FIA–APCI-HRMS method was successfully demonstrated for cytotoxicity screening (bioprofiling) and respective cytotoxin assignment. (Source: Metabolomics)
Source: Metabolomics - May 2, 2023 Category: Biology Source Type: research
Integrated clinical and metabolomic analysis of dengue infection shows molecular signatures associated with host-pathogen interaction in different phases of the disease
ConclusionThe results show elevated TNF- α and metabolites that are characteristic of viral infection and host response. IL10 and IFN-γ were not significant, consistent with the absence of any complications. (Source: Metabolomics)
Source: Metabolomics - May 2, 2023 Category: Biology Source Type: research
Chemical and cytotoxicity profiles of 11 pink pepper (Schinus spp.) samples via non-targeted hyphenated high-performance thin-layer chromatography
ConclusionThe developed non-targeted hyphenated RP-HPTLC –UV/Vis/FLD–bioluminescent cytotoxicity bioassay–FIA–APCI-HRMS method was successfully demonstrated for cytotoxicity screening (bioprofiling) and respective cytotoxin assignment. (Source: Metabolomics)
Source: Metabolomics - May 2, 2023 Category: Biology Source Type: research
