Integrated clinical and metabolomic analysis of dengue infection shows molecular signatures associated with host-pathogen interaction in different phases of the disease
ConclusionThe results show elevated TNF- α and metabolites that are characteristic of viral infection and host response. IL10 and IFN-γ were not significant, consistent with the absence of any complications. (Source: Metabolomics)
Source: Metabolomics - May 2, 2023 Category: Biology Source Type: research
Associations between sheep meat intake frequency and blood plasma levels of metabolites and lipoproteins in healthy Uzbek adults
ConclusionThe results showed that SMIF was confounded by nationality, sex, body mass index (BMI), age, intake frequency of total meat and fish in ascending order (p < 0.01). Multivariate and univariate data analyses showed differences in the levels of plasma metabolites and lipoproteins with respect to SMIF. The effect of SMIF after statistical adjustment by nationality, sex, BMI, age, intake frequency of total meat and fish decreased but remained significan t. Pyruvic acid, phenylalanine, ornithine, and acetic acid remained significantly lower in the high SMIF group, whereas choline, asparagine, and dimethylg...
Source: Metabolomics - April 26, 2023 Category: Biology Source Type: research
Segmental hair metabolomics analysis in pregnant women with pregnancy complications
ConclusionThe found metabolites provide us with extensive data on the ability to establish biomarkers for predicting, early detection and monitoring of PE. (Source: Metabolomics)
Source: Metabolomics - April 21, 2023 Category: Biology Source Type: research
Metabolomic profiles in relapsing –remitting and progressive multiple sclerosis compared to healthy controls: a five-year follow-up study
AbstractIntroduction and objectivesMultiple sclerosis (MS) is a disease of the central nervous system associated with immune dysfunction, demyelination, and neurodegeneration. The disease has heterogeneous clinical phenotypes such as relapsing –remitting MS (RRMS) and progressive multiple sclerosis (PMS), each with unique pathogenesis. Metabolomics research has shown promise in understanding the etiologies of MS disease. However, there is a paucity of clinical studies with follow-up metabolomics analyses. This 5-year follow-up (5YFU) co hort study aimed to investigate the metabolomics alterations over time between differ...
Source: Metabolomics - April 20, 2023 Category: Biology Source Type: research
A ketogenic diet alters mTOR activity, systemic metabolism and potentially prevents collagen degradation associated with chronic alcohol consumption in mice
ConclusionThis study sheds light on the influence that a KD alongside alcohol intake can exert on not just mTOR, but also their effect on metabolic reprogramming and the redox state. (Source: Metabolomics)
Source: Metabolomics - April 19, 2023 Category: Biology Source Type: research
Exploring the potential application of alternative nuclei in NMR based metabolomics
ConclusionsAlternative NMR active nuclei are useful for metabolomics. (Source: Metabolomics)
Source: Metabolomics - April 15, 2023 Category: Biology Source Type: research
Fetal effects of mild maternal COVID-19 infection: metabolomic profiling of cord blood
ConclusionWe present fetal biochemical changes related to intrauterine inflammation and altered energy metabolism in cases of mild maternal COVID-19 infection despite the absence of viral infection. Elucidation of the long-term consequences of these findings is imperative considering the large number of exposures in the population. (Source: Metabolomics)
Source: Metabolomics - April 15, 2023 Category: Biology Source Type: research
Exploring the potential application of alternative nuclei in NMR based metabolomics
ConclusionsAlternative NMR active nuclei are useful for metabolomics. (Source: Metabolomics)
Source: Metabolomics - April 15, 2023 Category: Biology Source Type: research
Fetal effects of mild maternal COVID-19 infection: metabolomic profiling of cord blood
ConclusionWe present fetal biochemical changes related to intrauterine inflammation and altered energy metabolism in cases of mild maternal COVID-19 infection despite the absence of viral infection. Elucidation of the long-term consequences of these findings is imperative considering the large number of exposures in the population. (Source: Metabolomics)
Source: Metabolomics - April 15, 2023 Category: Biology Source Type: research
Monitoring of age- and gender-related alterations of endocannabinoid levels in selected brain regions with the use of SPME probes
ConclusionSPME probes were able to isolate highly unstable endogenous compounds from intact tissue, and provided new tools for precise analysis of the level and distribution of ECs in different brain regions. Monitoring of ECs in brain samples is important not only in physiological conditions, but also may contribute to better understanding of the functioning of the endocannabinoid system in various disorders. (Source: Metabolomics)
Source: Metabolomics - April 12, 2023 Category: Biology Source Type: research
