Biomarkers of oxidative stress, diet and exercise distinguish soldiers selected and non-selected for special forces training
ConclusionCandidates selected during SFAS had higher pre-SFAS levels of circulating metabolites that were associated with resistance to oxidative stress, higher physical performance and higher diet quality. In contrast, non-selected candidates had higher levels of metabolites potentially indicating elevated oxidative stress. These findings indicate that Soldiers who were selected for continued Special Forces training enter the SFAS course with metabolites associated with healthier diets and better physical performance. Additionally, the non-selected candidates had higher levels of metabolites that may indicate elevated oxi...
Source: Metabolomics - April 11, 2023 Category: Biology Source Type: research
Performance assessment of an equine metabolomics model for screening a range of anabolic agents
AbstractIntroductionDespite their ban, Anabolic Androgenic Steroids (AAS) are considered as the most important threat for equine doping purposes. In the context of controlling such practices in horse racing, metabolomics has emerged as a promising alternative strategy to study the effect of a substance on metabolism and to discover new relevant biomarkers of effect. Based on the monitoring of 4 metabolomics derived candidate biomarkers in urine, a prediction model to screen for testosterone esters abuse was previously developed. The present work focuses on assessing the robustness of the associated method and define its sc...
Source: Metabolomics - April 7, 2023 Category: Biology Source Type: research
Serum metabolomic profiling identifies potential biomarkers in arthritis in older adults: an exploratory study
ConclusionThese results suggest that EORAneg and PMR have different serum metabolomic profiles that might be related to their pathobiology and can be used as biomarker to discriminate between both diseases. (Source: Metabolomics)
Source: Metabolomics - April 6, 2023 Category: Biology Source Type: research
Circulating metabolites as potential biomarkers for the early detection and prognosis surveillance of gastrointestinal cancers
ConclusionBlood-based metabolomics analysis is an efficient strategy for GI cancer screening, especially for malignant and benign diagnoses. The cancer-specific metabolic patterns process the potential for classifying tissue-of-origin in multi-cancer screening. Besides, the circulating metabolites for prognosis management of GI cancer is a promising area of research. (Source: Metabolomics)
Source: Metabolomics - April 4, 2023 Category: Biology Source Type: research
Metabolomic profiling of glucose homeostasis in African Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS-FS)
ConclusionWe extended the observations that metabolites are useful biomarkers in the identification of prediabetes in individuals at risk of type 2 diabetes in African Americans. We revealed, for the first time, differential ancestral effect of certain metabolites (i.e., glutamate) on glucose homeostasis traits. Our study highlights the need for additional comprehensive metabolomic studies in well-characterized multiethnic cohorts. (Source: Metabolomics)
Source: Metabolomics - April 2, 2023 Category: Biology Source Type: research
Metabolomic analysis of bone-derived exosomes in osteonecrosis of the femoral head based on UPLC –MS/MS
ConclusionOur results suggest that metabolomics has huge prospects for elucidating pathophysiology of ONFH. (Source: Metabolomics)
Source: Metabolomics - April 1, 2023 Category: Biology Source Type: research
Metabolomics of early myocardial ischemia
ConclusionWe investigated the earliest changes in metabolites of patients undergoing brief myocardial ischemia and found that ischemia led to changes throughout the lipid metabolism as early as 15 min post-intervention. (Source: Metabolomics)
Source: Metabolomics - April 1, 2023 Category: Biology Source Type: research
Metabolomic analysis of bone-derived exosomes in osteonecrosis of the femoral head based on UPLC –MS/MS
ConclusionOur results suggest that metabolomics has huge prospects for elucidating pathophysiology of ONFH. (Source: Metabolomics)
Source: Metabolomics - April 1, 2023 Category: Biology Source Type: research
Metabolomics of early myocardial ischemia
ConclusionWe investigated the earliest changes in metabolites of patients undergoing brief myocardial ischemia and found that ischemia led to changes throughout the lipid metabolism as early as 15 min post-intervention. (Source: Metabolomics)
Source: Metabolomics - April 1, 2023 Category: Biology Source Type: research
Evaluation of BAYESIL for automated annotation of 1H NMR data using limited sample volumes: application to African elephant serum
ConclusionsBAYESIL is valuable for limited sample1H NMR data analyses. (Source: Metabolomics)
Source: Metabolomics - March 30, 2023 Category: Biology Source Type: research
