Capillary electrophoresis-mass spectrometry as a tool for Caenorhabditis elegans metabolomics research
ConclusionCE-MS was successfully applied inC. elegans metabolomics, being able to recover known as well as identify novel putative biomarkers of longevity. (Source: Metabolomics)
Source: Metabolomics - June 23, 2023 Category: Biology Source Type: research
Inter-laboratory comparison of plant volatile analyses in the light of intra-specific chemodiversity
ConclusionOur ring trial shows that despite large efforts to standardise each VOC measurement step, the outcomes differed both qualitatively and quantitatively. Our results reveal sources of variation in plant VOC research and may help to avoid systematic errors in similar experiments. (Source: Metabolomics)
Source: Metabolomics - June 23, 2023 Category: Biology Source Type: research
Capillary electrophoresis-mass spectrometry as a tool for Caenorhabditis elegans metabolomics research
ConclusionCE-MS was successfully applied inC. elegans metabolomics, being able to recover known as well as identify novel putative biomarkers of longevity. (Source: Metabolomics)
Source: Metabolomics - June 23, 2023 Category: Biology Source Type: research
Metabolomics unravels subtype-specific characteristics related to neoadjuvant therapy response in breast cancer patients
ConclusionsIt is possible to identify differential metabolomics patterns between complete and partial responses to neoadjuvant therapy, being this metabolomic profile specific for each breast cancer subtype. (Source: Metabolomics)
Source: Metabolomics - June 21, 2023 Category: Biology Source Type: research
Metabolic signature of cervical mucus in ewe breeds with divergent cervical sperm transport: a focus on metabolites involved in amino acid metabolism
ConclusionThe suboptimal amino acid profile in the cervical mucus of the low fertility Suffolk breed may have negative consequences for sperm transport. (Source: Metabolomics)
Source: Metabolomics - June 20, 2023 Category: Biology Source Type: research
The metabolic contribution of SKN-1/Nrf2 to the lifespan of Caenorhabditis elegans
ConclusionOur multi-omics results consistently revealed that the cytoprotective mechanisms, including cellular redox reactions and xenobiotic detoxification system, contribute to the roles of SKN-1/Nrf2 in the lifespan of worms. (Source: Metabolomics)
Source: Metabolomics - June 8, 2023 Category: Biology Source Type: research
Mitochondrial damage-induced abnormal glucose metabolism with ageing in the hippocampus of APP/PS1 mice
ConclusionThis study investigated the abnormal glucose metabolism associated with age-related damage to mitochondria in the hippocampus of APP/PS1 mice. These findings provide new insights into the pathogenesis of AD. (Source: Metabolomics)
Source: Metabolomics - June 8, 2023 Category: Biology Source Type: research
MetaPro: a web-based metabolomics application for LC-MS data batch inspection and library curation
ConclusionWe offer MetaPro as a web-based application characterized by fast batch QC inspection and credible spectral curation towards high-throughput metabolomics data. It aims to resolve the analysis difficulty in semi-targeted metabolomics. (Source: Metabolomics)
Source: Metabolomics - June 8, 2023 Category: Biology Source Type: research
The metabolic contribution of SKN-1/Nrf2 to the lifespan of Caenorhabditis elegans
ConclusionOur multi-omics results consistently revealed that the cytoprotective mechanisms, including cellular redox reactions and xenobiotic detoxification system, contribute to the roles of SKN-1/Nrf2 in the lifespan of worms. (Source: Metabolomics)
Source: Metabolomics - June 8, 2023 Category: Biology Source Type: research
Mitochondrial damage-induced abnormal glucose metabolism with ageing in the hippocampus of APP/PS1 mice
ConclusionThis study investigated the abnormal glucose metabolism associated with age-related damage to mitochondria in the hippocampus of APP/PS1 mice. These findings provide new insights into the pathogenesis of AD. (Source: Metabolomics)
Source: Metabolomics - June 8, 2023 Category: Biology Source Type: research
MetaPro: a web-based metabolomics application for LC-MS data batch inspection and library curation
ConclusionWe offer MetaPro as a web-based application characterized by fast batch QC inspection and credible spectral curation towards high-throughput metabolomics data. It aims to resolve the analysis difficulty in semi-targeted metabolomics. (Source: Metabolomics)
Source: Metabolomics - June 8, 2023 Category: Biology Source Type: research
Tuberculosis is associated with sputum metabolome variations, irrespective of patient sex or HIV status: an untargeted GCxGC-TOFMS study
ConclusionsOur findings highlight the importance of considering confounders in metabolomics studies in order to identify unambiguous disease biomarkers. (Source: Metabolomics)
Source: Metabolomics - June 7, 2023 Category: Biology Source Type: research
