Acute changes in the metabolome following resistance exercise combined with intake of different protein sources (cricket, pea, whey)
ConclusionThe blood, urine and muscle metabolome showed different and supplementary responses to exercise and ingestion of the different protein sources, and in synergy the summarized results provided a more complete picture of the metabolic state of the body. (Source: Metabolomics)
Source: Metabolomics - November 24, 2023 Category: Biology Source Type: research

High fat diet reveals sex-specific fecal and liver metabolic alterations in C57BL/6J obese mice
This study utilizes a mouse (C57BL/6J) model of obesity to analyze liver and fecal metabolic profiles at various time points of dietary exposure: 5, 9, and 12 months in control or high fat diet (HFD)-exposed mice. Our study discovered that the female HFD group has a more discernable perturbation and set of significant changes in metabolic profiles than the male HFD group. In the female mice, HFD fecal metabolites including pyruvate, aspartate, and glutamate were lower than control diet-exposed mice after both 9th and 12th month exposure time points, while lactate and alanine were significantly downregulated only at the 12t...
Source: Metabolomics - November 24, 2023 Category: Biology Source Type: research

Maternal exposure to polystyrene nanoplastics alters fetal brain metabolism in mice
ConclusionMaternal exposure to polystyrene nanoplastics caused abnormal fetal brain metabolism in mice. The present study demonstrates the potential impacts of nanoplastic exposure during fetal development and motivates further studies to evaluate the risk to human pregnancies. (Source: Metabolomics)
Source: Metabolomics - November 21, 2023 Category: Biology Source Type: research

Highlights of three metabolites HDL and reduction in blood pressure values after dietary fiber supplementation in overweight and obese normotensive women: a metabolomic study
ConclusionThe synergism of the functions of these statistically highlighted metabolites contributed to prevention the increase in SBP after fiber intervention in overweight and obese normotensive women. (Source: Metabolomics)
Source: Metabolomics - November 17, 2023 Category: Biology Source Type: research

Bone marrow plasma metabonomics of idiopathic acquired aplastic anemia patients using 1H nuclear magnetic resonance spectroscopy
ConclusionThe study highlights the significant metabolic alterations in the BM plasma of AA patients which may have implication in the disease pathobiology.Graphical Abstract (Source: Metabolomics)
Source: Metabolomics - November 17, 2023 Category: Biology Source Type: research

Highlights of three metabolites HDL and reduction in blood pressure values after dietary fiber supplementation in overweight and obese normotensive women: a metabolomic study
ConclusionThe synergism of the functions of these statistically highlighted metabolites contributed to prevention the increase in SBP after fiber intervention in overweight and obese normotensive women. (Source: Metabolomics)
Source: Metabolomics - November 17, 2023 Category: Biology Source Type: research

Bone marrow plasma metabonomics of idiopathic acquired aplastic anemia patients using 1H nuclear magnetic resonance spectroscopy
ConclusionThe study highlights the significant metabolic alterations in the BM plasma of AA patients which may have implication in the disease pathobiology.Graphical Abstract (Source: Metabolomics)
Source: Metabolomics - November 17, 2023 Category: Biology Source Type: research

Clinical metabolomics by NMR revealed serum metabolic signatures for differentiating sarcoidosis from tuberculosis
ConclusionThe metabolic disturbances not only found to be well in concordance with various previous reports, these further demonstrated very high sensitivity and specificity to distinguish SAR from TB patients suggesting serum metabolomics analysis can serve as surrogate method in the diagnosis and clinical management of SAR. (Source: Metabolomics)
Source: Metabolomics - November 8, 2023 Category: Biology Source Type: research

Metabolomics 2022 workshop report: state of QA/QC best practices in LC –MS-based untargeted metabolomics, informed through mQACC community engagement initiatives
ConclusionsOngoing efforts will continue to identify, catalog, harmonize, and disseminate QA/QC best practices, including outreach activities, to establish and continually update QA/QC guidelines. (Source: Metabolomics)
Source: Metabolomics - November 8, 2023 Category: Biology Source Type: research

Clinical metabolomics by NMR revealed serum metabolic signatures for differentiating sarcoidosis from tuberculosis
ConclusionThe metabolic disturbances not only found to be well in concordance with various previous reports, these further demonstrated very high sensitivity and specificity to distinguish SAR from TB patients suggesting serum metabolomics analysis can serve as surrogate method in the diagnosis and clinical management of SAR. (Source: Metabolomics)
Source: Metabolomics - November 8, 2023 Category: Biology Source Type: research

Metabolomics 2022 workshop report: state of QA/QC best practices in LC –MS-based untargeted metabolomics, informed through mQACC community engagement initiatives
ConclusionsOngoing efforts will continue to identify, catalog, harmonize, and disseminate QA/QC best practices, including outreach activities, to establish and continually update QA/QC guidelines. (Source: Metabolomics)
Source: Metabolomics - November 8, 2023 Category: Biology Source Type: research

Metabolomic profiling of preterm birth in pregnant women living with HIV
ConclusionThis study identified previously known as well as novel metabolomic features of preterm birth in pregnant women living with HIV. Validation of these models in a larger, independent cohort is necessary to ascertain whether they can be utilized to predict preterm birth during a stage of gestation that allows for therapeutic intervention or more effective resource allocation. (Source: Metabolomics)
Source: Metabolomics - October 25, 2023 Category: Biology Source Type: research

Identification of potential quality markers in Indonesia ’s Arabica specialty coffee using GC/MS-based metabolomics approach
ConclusionGC/MS combined with OPLS regression analysis suggested galactinol as a quality marker and provide an early screening method for Arabica coffee quality that complements the cupping test performed by certified panelists. (Source: Metabolomics)
Source: Metabolomics - October 25, 2023 Category: Biology Source Type: research

Metabolomic profiling of preterm birth in pregnant women living with HIV
ConclusionThis study identified previously known as well as novel metabolomic features of preterm birth in pregnant women living with HIV. Validation of these models in a larger, independent cohort is necessary to ascertain whether they can be utilized to predict preterm birth during a stage of gestation that allows for therapeutic intervention or more effective resource allocation. (Source: Metabolomics)
Source: Metabolomics - October 25, 2023 Category: Biology Source Type: research