Sarcopenic Obesity in Chronic Kidney Disease: Challenges in Diagnosis using Different Diagnostic Criteria
Obesity and muscle impairment (low muscle mass or strength) are present in chronic kidney disease (CKD) and associated to worse prognosis. However, the various existing definitions for these conditions make the diagnosis variable. The aim of the study was to evaluate the agreement between diagnostic criteria for sarcopenic obesity and its components in CKD. Two hundred and sixty seven patients with CKD were included in the study. We assessed body composition by dual energy X-ray absorptiometry (DXA) and muscle function by handgrip strength (HGS); adiposity by BMI, waist circumference (WC), fat mass index (FMI), and percent...
Source: Medical Principles and Practice - June 2, 2021 Category: Internal Medicine Source Type: research

Troponin elevation in sickle cell disease
Abstract: Objective: Sickle Cell Disease (SCD) is associated with cardiovascular abnormalities. Troponin is not typically measured in this population and significance of having abnormal troponin is unknown. We wanted to evaluate use of troponin and factors that predispose troponin elevation in patient s admitted with Sickle Cell Pain Crisis (SCPC). Methods: We reviewed data of consecutive patients admitted to a tertiary care hospital between 2006-2011 with a diagnosis of SCPC. Subjects with Elevated Troponin (ET) group (troponin I> 0.04 ng/ml) were compared with those with Normal Troponin (NT group) for d...
Source: Medical Principles and Practice - June 1, 2021 Category: Internal Medicine Source Type: research

Evaluation of the nature and etiologies of risk factors for diaphyseal atypical femoral fractures
Objectives: Differences in the mechanisms of subtrochanteric and diaphyseal atypical femoral fractures (AFFs) have been speculated in studies that have analyzed differences in the patients ’ backgrounds. However, the etiologies of each type of AFF have not been investigated in detail. Therefore, this study aimed to investigate the nature and etiologies of the risk factors for diaphyseal AFFs. Materials and Methods: Eighty consecutive Japanese patients with 91 diaphyseal AFFs (the AF F group) and 110 age-matched female patients with osteoporosis (the non-AFF control group) were included. Their clinical data were compa...
Source: Medical Principles and Practice - May 30, 2021 Category: Internal Medicine Source Type: research

Is Hair Removal Necessary after Crystallized Phenol Treatment in Pilonidal Disease?
Conclusion: Regular hair removal during, and at least 30 months after, crystallized phenol treatment reduced recurrences in patients with PSD. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - April 28, 2021 Category: Internal Medicine Source Type: research

Does hair removal necessary after crystallized phenol treatment in pilonidal disease?
Conclusion: Regular hair removal during and at least 30 months after crystalliz ed phenol treatment reduced recurrences in patients with pilonidal sinus disease. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - April 28, 2021 Category: Internal Medicine Source Type: research

Marginal Integrity of CAD/CAM Ceramic Crowns Using Two Different Finish Line Designs
Conclusions- CEREC system provides clinically acceptable crowns and can safely be utilized in dental treatment. Therefore, Contemporary Dental Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM) restorations should be considered as a safe treatment modality by dental professionals. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - April 25, 2021 Category: Internal Medicine Source Type: research

Rapid Serological Tests for Sars-Cov-2: Diagnostic Performance of Four Commercial Assays
Conclusion. Our data demonstrate the excellent performance of LFA for the diagnoses of definit e or probable SARS-CoV-2 infection. There was substantial heterogeneity in sensitivities of IgM and IgG antibodies among the manufacturers. LFA tests cannot replace molecular diagnostics, but should be used as additional screening tool. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - April 21, 2021 Category: Internal Medicine Source Type: research

Antibody-Dependent Enhancement and the Critical Pattern of COVID-19: Possibilities and Considerations
Coronavirus disease 2019 (COVID-19), a pandemic infection with profound effects on human society, has been emerged recently and rigorously challenged our ability to control viral infections. Although at the beginning of the COVID-19 outbreak, the epidemic seems controllable in Southern Iran, the disease presents a critical pattern as of May 2020. After a few months of COVID-19 emergence, in a twisted turn of events, the severity and mortality of COVID-19 increased dramatically. It has been proposed that the antibodies obtained from previous exposure to local circulating human coronaviruses or possibly SARS-CoV-2 might cont...
Source: Medical Principles and Practice - April 20, 2021 Category: Internal Medicine Source Type: research

Antithrombotic Management in Ischemic Stroke with Essential Thrombocythemia: Current Evidence and Dilemmas
Thrombotic diseases like ischemic stroke are common complications of essential thrombocythemia (ET) due to abnormal megakaryopoiesis and platelet dysfunction. Ischemic stroke in ET can occur as a result of both cerebral arterial and venous thrombosis. Management of ET is aimed at preventing vascular complications including thrombosis. Acute management of ischemic stroke in ET is the same as that in the general population without myeloproliferative disorder. However, an ET patient with ischemic stroke is at high risk for re-thrombosis and therefore additionally managed with cytoreductive therapy and antithrombotic agents. G...
Source: Medical Principles and Practice - April 12, 2021 Category: Internal Medicine Source Type: research

Effect of Photobiomodulation Therapy Following Direct Pulp Capping on Postoperative Sensitivity by Thermal Stimulus: A Retrospective Study
Conclusion: Photobiomodulation therapy is an effective method for enhancing patient comfort by reducing thermal sensitivity following direct pulp capping procedures. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - April 6, 2021 Category: Internal Medicine Source Type: research

Screening a prognosis-related target gene in patients with HER-2 positive breast cancer by bioinformatics analysis
Conclusions: The present study identified RRM2 as a target gene associated with the initiation, progression and prognosis of HER-2 positive breast cancer, which may contribute to provide a new biomarker and therapeutic target. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - April 5, 2021 Category: Internal Medicine Source Type: research

In vitro and in vivo Evaluation of Ibuprofen Nanosuspensions for Enhanced Oral Bioavailability
Conclusion: IBU/PP/TW nanosuspensions showed enhanced in vitro dissolution as well as faster rate and higher extent of absorption as indicated from the higher Cmax, shorter tmax and larger AUC. The in vivo data supported the in vitro results. Nanosuspensions prepared by ultra-high-pressure-homogenization technique can be used as a good formulation strategy to enhance the rate and extent of absorption of poorly soluble drugs. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - April 5, 2021 Category: Internal Medicine Source Type: research

High-Level Resistance to Erythromycin and Tetracycline and Dissemination of Resistance Determinants among Clinical Enterococci in Iran
Conclusion: A high prevalence of high-level resistance to both erythromycin and tetracycline was documented. Alterations at the ribosomal level was more frequently detected in erythromycin and tetracycline resistance than efflux systems. Concurrent resistance mechanisms were more involved in resistance to erythromycin than tetracycline. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - March 30, 2021 Category: Internal Medicine Source Type: research

High level resistance to Erythromycin and Tetracycline and dissemination of resistance determinants among clinical enterococci in Kerman-Iran
Conclusion: High prevalence of high level resistance to both erythr omycin and tetracycline was documented. The alteration at ribosomal level, had bigger role in erythromycin and tetracycline resistance than efflux systems. Concurrent resistance mechanisms were more involved in resistance to erythromycin than tetracycline. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - March 30, 2021 Category: Internal Medicine Source Type: research

Reply to β€œIs Ventricular Arrhythmias the End for All Conditions?”
Med Princ Pract (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - March 30, 2021 Category: Internal Medicine Source Type: research

Dysfunctional coping mediates the relationship between stress and mental health in health care staff working amid COVID-19 pandemic.
Conclusion: Our observations support the assumption about a controlling role of coping in the relationship between work-related stress and mental health outcomes in the medical staff working amid pandemic. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - March 28, 2021 Category: Internal Medicine Source Type: research

Renal involvement in Mediterranean spotted fever – clinical and histopathological data
Conclusion: Renal pathology associated with MSF rickettsial infection consists of systemic small vessel vasculitis and vascular injury leading to ARF in the most severe cases. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - March 28, 2021 Category: Internal Medicine Source Type: research

Coffee Consumption and Cancer Risk; An Assessment of the Health Implications Based on Recent Knowledge
A significant number of studies suggests that coffee consumption reduces cancer risk. This beneficial effect is usually ascribed to the presence of polyphenolic antioxidants and anti- inflammatory agents, including caffeine, cafestol, kahweol and chlorogenic acids. To summarize recent literature on this subject we performed a bibliographic search in PubMed and Embase over the period January 2005 to December 2020 to identify cohort studies and meta-analysis (with data collection ensuring quality of selected reports) that could provide quantitative data on the relationship between coffee consumption and common cancers. The t...
Source: Medical Principles and Practice - March 23, 2021 Category: Internal Medicine Source Type: research

A refinement of clinical tumour marker monitoring - why not use an inverse value of doubling time?
We report that implementation of inverse value (ePSA) rather than HT or DT has distinct advantages: (1) values are valid when PSA is unchanged (ePSA equals zero), (2) the concept of ePSA is ea sily comprehendible – it is a growth fraction, (3) ePSA fluctuates in a narrow range – easy to interpret, no large numbers, (4) no mathematical flaws (no positive skewing). Exploring ePSA norm as (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - March 18, 2021 Category: Internal Medicine Source Type: research

Reported and unreported potentially important incidental findings in urgent nonenhanced abdominal CT for renal colic
PURPOSE: To retrospectively evaluate the prevalence of reported and unreported potentially important incidental findings in consecutive nonenhanced abdominal CTs performed specifically for renal colic in the urgent setting. METHOD: One radiologist, blinded to the finalized report, retrospectively re-evaluated nonenhanced abdominal CTs performed from January through December 2017 on adult patients from the Emergency Department with the specific request of urgent evaluation for renal colic, searching for potentially important incidental findings. RESULTS: The CTs of 312 patients were included in the study. Thirty-eight fin...
Source: Medical Principles and Practice - March 14, 2021 Category: Internal Medicine Source Type: research

Clinical and Radiological Follow-Up Results of Patients with Sequestered Lumbar Disc Herniation: A Prospective Cohort Study
Conclusions: Spontaneous regression was observed in the 6th month MRI in most of the nonoperated sequestered LDH patients with conservative treatment. Improvements in pain and disability scores were higher among the operated patients at the early stage, whereas they were found to have no difference with spontaneous regression patients at the 6th month. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - February 17, 2021 Category: Internal Medicine Source Type: research

Sleep deprivation interferes with jak/stat signaling pathway and myogenesis in masseter muscle of rats
Conclusion. The results showed the presence of inflammatory infiltrate in the PSD+V and PSD+MET groups and atrophy. Histomorphometry showed that Cellular Profile Area decreased while Cellular Density increased in both experimental groups. Expression of p-STAT 3, MyoD and MyoG increased in PSD+V group, while the PSD+MET group increased expression of IL-6 and p-STAT 3. Our results are consistent with notion that sleep deprivation induced inflammatory response and atrophy in masseter muscle of rats. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - February 17, 2021 Category: Internal Medicine Source Type: research

Performance Comparison of GeneXpert MTB/RIF and ProbeTec ET Tests for Rapid Molecular Diagnosis of Extrapulmonary Tuberculosis in a Low TB/MDR-TB Incidence Country
Conclusions: Although performance of both tests was suboptimal for AFB-negative/culture-positive samples, Xpert performed better than PTec-ET and also detected more cases of AFB-negative/culture-nagative/histopathology-positive samples. PTec-ET was positive in three while Xpert was positive in all six culture-positive CSF specimens for rapid diagnosis of TB meningitis. Xpert was thus superior to PTec-ET or smear microscopy in rapidly diagnosing EPTB. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - February 15, 2021 Category: Internal Medicine Source Type: research

An Update on the Epidemiological Features of Imported Schistosomiasis and Cystic Echinococcosis in Kuwait, 2010-2018
Objective: Kuwait is considered a non-endemic country for most parasitic infections. However, ~70% of 4.7 million residents in Kuwait are expatriates from Asian and African countries which are endemic for parasitic infections. Results of microbiological investigations for schistosomiasis and cystic echinococcosis performed in a reference national laboratory were retrospectively collected and analyzed to provide an insight on the epidemiology of these two neglected tropical diseases in Kuwait. Subjects and Methods: Schistosoma infection in fecal and urine specimens from suspected patients was detected by microscopy. Schist...
Source: Medical Principles and Practice - January 31, 2021 Category: Internal Medicine Source Type: research

Visual Acuity Outcomes after Phacoemulsification in Eyes with Good Visual Acuity before Cataract Surgery
Abstract Objective: To analyze cataract surgery outcomes and related factors in eyes presenting with good visual acuity. Subject and Methods: Retrospective longitudinal of patients undergoing phacoemulsification between the years 2014-2018 in Moorfields Eye Hospital and satellite units. Pre- and postoperative visual acuity (unaided, with glasses, with pinhole) were analyzed. Inclusion criteria were age ≥40 years and pinhole visual acuity ≥6/9 preoperatively. Exclusion criteria were no postoperative visual acuity data. VA change variable was also defined according to postoperative visual acuity being above or below ...
Source: Medical Principles and Practice - January 24, 2021 Category: Internal Medicine Source Type: research

Acceptance of a COVID-19 Vaccine and its Related Determinants among the General Adult Population in Kuwait
Objective: To determine the acceptance of a potential coronavirus disease 2019 (COVID-19) vaccine among the general adult population in Kuwait and assess its determinants. Subjects and Methods: A web-based cross-sectional study was conducted by enrolling adults living in Kuwait (n = 2368; aged ≥21 years). Acceptance of a COVID-19 vaccine was inferred if participants indicated that they “definitely or probably will accept vaccination against COVID-19 once a vaccine is available.” Associations were explored by applying a modified Poisson regression to estimate and infer adjusted preva lence ratios (aPR) and t...
Source: Medical Principles and Practice - January 21, 2021 Category: Internal Medicine Source Type: research

Is ventricular arrhythmias the end for all conditions?
Dear Editor, We read the article entitled “Abnormal Dispersion of Ventricular Repolarization as a Risk Factor in Patients with Human Immunodeficiency Virus: Tp-e Interval, Tp-e/QTc Ratio” by Unal Evren et al. with interest[1]. The authors evaluated the changes in Tp-e interval, Tp-e/QT and Tp-e/corrected QT (QTc) ratios, and traditional electrocardiographic features of electrical dispersion in adults infected with Human Immunodeficiency Virus (HIV) and their study revealed that the cTp-e interval, Tp-e/QT and Tp-e/QTc ratios were prolonged and correlated to the severity of the disease in HIV-infected patients....
Source: Medical Principles and Practice - January 12, 2021 Category: Internal Medicine Source Type: research

Is ventricular arrhythmias the end for all conditions ?
Dear Editor, We read the article entitled “Abnormal Dispersion of Ventricular Repolarization as a Risk Factor in Patients with Human Immunodeficiency Virus: Tp-e Interval, Tp-e/QTc Ratio” by Unal Evren et al. with interest[1]. The authors evaluated the changes in Tp-e interval, Tp-e/QT and Tp-e/corrected QT (QTc) ratios, and traditional electrocardiographic features of electrical dispersion in adults infected with Human Immunodeficiency Virus (HIV) and their study revealed that the cTp-e interval, Tp-e/QT and Tp-e/QTc ratios were prolonged and correlated to the severity of the disease in HIV-infected patients....
Source: Medical Principles and Practice - January 12, 2021 Category: Internal Medicine Source Type: research

Preoperative Controlling Nutritional Status plus Tumor Burden Score for the Assessment of Prognosis after Curative Liver Resection for Hepatocellular Carcinoma
Conclusion: The CONUT-TB score is a valuable predictor of survival in patients with HCC after liver resection. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - December 23, 2020 Category: Internal Medicine Source Type: research

Preoperative Controlling Nutritional Status plus Tumor Burden (CONUT-TB) Score for the Assessment of Prognosis after Curative Liver Resection for Hepatocellular Carcinoma
Conclusions: The CONUT-TB score is a valuable predictor of survival in patients with HCC after liver resection. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - December 23, 2020 Category: Internal Medicine Source Type: research

Plasma Levels of Alpha and Gamma Synucleins in Autism Spectrum Disorder: An Indicator of Severity
Conclusions: Our study showed that alteration in α-synuclein and γ-synuclein might be associated with ASD pathogenesis and could be an indicator of the severity of the disorder. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - December 20, 2020 Category: Internal Medicine Source Type: research

Plasma levels of Alpha and Gamma Synuclein in Autism Spectrum Disorder: A Severity Indicator
Objectives: To correlate plasma levels of α-synuclein and γ-synuclein in ASD children in order to elucidate their possible contribution to the pathogenesis of ASD and to study their association with the severity of the disorder. Subjects and methods: plasma level of Alpha and Gamma Synuclein in 38 male children diagnosed with autism spect rum disorder (ASD) compared with 40 healthy age-matched male children by using enzyme linked immunosorbent assay (ELISA). Results: Our results showed that plasma levels of α-synuclein (18.02 ± 5.3 pg/mL) were significantly higher in ASD children compared to contro...
Source: Medical Principles and Practice - December 20, 2020 Category: Internal Medicine Source Type: research

Heart rate variability-measured stress and academic achievement in medical students
Conclusion: This study shows that medical students with higher stress measured by HRV have higher academic achievement, especially in written exam. Further studies are needed to reconfirm the results of this study and to assess the long-term effects of HRV measured stress on medical education. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - December 15, 2020 Category: Internal Medicine Source Type: research

Contents Vol. 29, 2020
Med Princ Pract 2020;29:I –VIII (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - December 9, 2020 Category: Internal Medicine Source Type: research

List of Reviewers Vol. 29, 2020
Med Princ Pract 2020;29:591 –592 (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - December 9, 2020 Category: Internal Medicine Source Type: research

Metabolomics - the stethoscope for the 21st century
Metabolomics offers systematic identification and quantification of all metabolic products from the human body. This field could provide clinicians with new sets of diagnostic biomarkers for disease states in addition to quantifying treatment response to medications at an individualised level. This literature review aims to highlight the technology underpinning metabolic profiling, identify potential applications of metabolomics in clinical practice and discuss the translational challenges that the field faces. We searched PubMed, Medline and Embase for primary and secondary research articles regarding clinical application...
Source: Medical Principles and Practice - December 2, 2020 Category: Internal Medicine Source Type: research

Periodization in Anterior Cruciate Ligament Rehabilitation: A Novel Framework
More than 250,000 anterior cruciate ligament (ACL) injuries occur each year in the USA, and approximately 65% of these injuries undergo reconstructive surgery. Appropriate rehabilitation after ACL reconstruction can yield predictably good outcomes, with return to previous levels of activity and high knee function. At present, periodization is used at all levels of sports training. Whether conceptualized and directed by coaches, or by athletes themselves, competitors structure their training in a cyclic fashion, enabling athletes to best realize their performance goals. In practical application, sport physical therapists us...
Source: Medical Principles and Practice - December 2, 2020 Category: Internal Medicine Source Type: research

Pulseless Electrical Activity: Detection of Underlying Causes in a Prehospital Setting
The proportion of out-of-hospital cardiac arrests (OHCA) with pulseless electrical activity (PEA) as initial rhythm is increasing. PEA should be managed by identifying the underlying cause of the arrest and treating it accordingly. This often poses a challenge in the chaotic prehospital environment with only limited resources available. The aim of this study was to review the diagnostic tools, available in a prehospital setting, and their interpretation during cardiac arrest with PEA as initial rhythm. A systematic literature search of the Pubmed database was performed. Articles were assessed for eligibility by title, abst...
Source: Medical Principles and Practice - November 29, 2020 Category: Internal Medicine Source Type: research

Assessment of clinical characteristics and mortality-associated factors in COVID-19 Critical cases in Kuwait
Conclusion This study describes the clinical characteristics and predictors of mortality among ICU patients. Early identification of risk factors to mortality might help in their better outcome. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - November 15, 2020 Category: Internal Medicine Source Type: research

Hyperhaemolytic Syndrome in Sickle cell disease: clearing the cobwebs
Sickle cell anaemia presents with a dynamic background haemolysis and deepening anaemia. This increases the demand for transfusion if any additional strain on haemopoiesis is encountered due to any other physiological or pathological. Patients with cerebrovascular accident are placed on chronic blood transfusion; those with acute sequestration and acute chest syndrome are likewise managed with blood transfusion. These patients are prone to develop blood transfusion complications including alloimmunization and hyperhaemolytic syndrome (HHS). This term is used to describe haemolysis of both transfused and ‘own’ r...
Source: Medical Principles and Practice - November 10, 2020 Category: Internal Medicine Source Type: research

Are there differences in arteriovenous fistulae created for hemodialysis between nephrologists and vascular surgeons?
Objective: Arteriovenous fistulae can be a reason for frustration among nephrologists dependent on surgeons. This is why nephrologists in many centers have begun to create arteriovenous fistulas themselves. The aim of this study was to determine possible differences and predictive parameters for arteriovenous fistula function in patients whose fistulas were created by a nephrologist or a vascular surgeon. Methods. The study was organized as a retrospective, descriptive-analytical study of interventions by nephrologists and vascular surgeons during a period of 15 years. The total number of arteriovenous fistulae created by...
Source: Medical Principles and Practice - October 28, 2020 Category: Internal Medicine Source Type: research

The usefulness of fecal calprotectin testing in pediatric gastroenterology clinical practice
Abstract Gastrointestinal tract symptoms such as abdominal pain, constipation, diarrhea, and fever are frequent causes of visits to the pediatrician. The increasing prevalence of chronic gastrointestinal tract diseases, and the falling median age of their onset, indicate the need to identify new diagnostic methods that can differentiate inflammatory bowel diseases from other gastrointestinal tract conditions. A promising non-invasive and useful marker of intestinal inflammation is fecal calprotectin. The manuscript summarizes currently available information on the use of fecal calprotectin in the diagnosis and monitoring ...
Source: Medical Principles and Practice - October 28, 2020 Category: Internal Medicine Source Type: research

CircHIPK3 Promotes Thyroid Cancer Tumorigenesis and Invasion through the Mirna-338-3p/RAB23 Axis
Conclusion: The downregulation of circHIPK3 significantly reduced the migration, invasion and proliferation of thyroid carcinoma. Then, we demonstrated that circHIPK3 up-regulated the expression of its targe t gene RAB23 by sponging miR-338-3p to promote the tumorigenesis and invasiveness of thyroid cancer. This study is the first to find that circHIPK3 plays the role of oncogenetic circRNA in thyroid cancer, which may provide new insights into how circRNA affects the progression of thyroid cancer. Our study also showed that circHIPK3 could be a novel biomarker for thyroid cancer. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - October 25, 2020 Category: Internal Medicine Source Type: research

ARIA 2019 Care pathways for allergic rhinitis in Kuwait health care system
This article presents the specificity of heath care system in Kuwait in regards to management of AR, with the intention to introduce proposed ICP and adopt latest ARIA recommendations. Guidelines for ICP includes views of patients and healthcare providers and covers key areas of allergic rhinitis management. This model of guidelines support real life health care better than traditional mod-els. Aiming at improving both pharmacotherapy and allergy immunotherapy (AIT), ARIA recommendations will be locally integrated in the health care system. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - October 22, 2020 Category: Internal Medicine Source Type: research

Elevated IL-38 Serum Levels in Newly Diagnosed Multiple Sclerosis and Systemic Sclerosis Patients
Conclusion: The higher serum levels of IL-38 in new or recently untreated cases of MS and SSc patients than in treated patients and healthy controls suggest the possible role of this cytokine in the development of these diseases or as part of a feedback loop to attenuate the inflammatory conditions in early stages of these diseases.Med Princ Pract (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - October 20, 2020 Category: Internal Medicine Source Type: research

Pentoxifylline, a drug with antiviral, anti-inflammatory and bronchodilatory effects may be a possible drug candidate for SARS-CoV-2
In December 2019, a new coronavirus, named SARS-CoV-2, has emerged from China causing pneumonia outbreaks first in the Wuhan region and have now spread worldwide but there are still no “specific drug” available. In the difficulty where new synthesized drug cannot be applied immediately to patients, “conventional drug in new use” becomes a feasible solution. Chloroquine, remdesivir, favipiravi, lopinavir, ribavirin or ritonavir have shown efficacy to inhibit coronavirus in vitro. Pentoxifylline, a drug with anti-inflammatory, immunomodulatory and bronchodilatory effects, previously showed efficacy to...
Source: Medical Principles and Practice - October 12, 2020 Category: Internal Medicine Source Type: research

Association of patients ’ perception of quality of healthcare received and colorectal cancer screening uptake: An analysis of two national surveys in the United States
Conclusion: Our study suggested that patients who reported receiving lower quality of healthcare servi ces were less likely to have undergone and be compliant with CRC screening recommendations. It is important to pay close attention to patient feedback surveys in order to improve healthcare delivery. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - October 12, 2020 Category: Internal Medicine Source Type: research

Clinical Effects of Xanthine Oxidase Inhibitors in Hyperuricemic Patients
In conclusion, xanthine oxidase inhibitors remain the first choice uric acid lowering drug for chronic treatment. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - October 8, 2020 Category: Internal Medicine Source Type: research

Efficacy of low carbohydrate ketogenic diet in the treatment of Type 2 Diabetes
Low carbohydrate ketogenic diet (LCKD), originally used as a treatment for childhood epilepsy is currently gaining acceptance as a nutritional therapy for obesity and type 2 diabetes. In addition, this diet has a positive effect on body weight, blood glucose level, glycosylated hemoglobin, plasma lipid profile, neurological disorders and cancer. This review focus on the therapeutic effectiveness, negative effects and the rationale of using LCKD for the treatment Type 2 diabetes. It is shown that LCKD contributes to the reduction in the intake of insulin and oral antidiabetic drugs in patients with type 2 diabetes. Furtherm...
Source: Medical Principles and Practice - October 8, 2020 Category: Internal Medicine Source Type: research

Modulation of Immune Cell Subsets by HCV Compared to Healthy Subjects and by Antiviral Therapy in Early Virologic Response HCV Genotype 4 Compensated Liver Disease Patients
This study aimed to investigate the absolute count of certain immune cell subsets in untreated HCV-infected patients compared to healthy subjects and during pegylated interferon- α and ribavirin (PegIFN/RBV) therapy. Materials and Methods: Sixty HCV genotype 4-infected patients were treated with PegIFN/RBV therapy for 52 weeks. Efficacy was measured by the early virologic response (EVR) at post-therapy. Absolute count of mature T, T helper, T cytotoxic, T activated, Natura l Killer (NK), Natural Killer/T (NKT), B, T regulatory cells (Treg) and T helper: T cytotoxic cells ratio were longitudinally analyzed by flow cyt...
Source: Medical Principles and Practice - September 22, 2020 Category: Internal Medicine Source Type: research