Modulation of Immune Cell Subsets by HCV Compared to Healthy Subjects and by Antiviral Therapy in Early Virologic Response HCV Genotype 4 Compensated Liver Disease Patients
This study aimed to investigate the absolute count of certain immune cell subsets in untreated HCV-infected patients compared to healthy subjects and during pegylated interferon- α and ribavirin (PegIFN/RBV) therapy. Materials and Methods: Sixty HCV genotype 4-infected patients were treated with PegIFN/RBV therapy for 52 weeks. Efficacy was measured by the early virologic response (EVR) at post-therapy. Absolute count of mature T, T helper, T cytotoxic, T activated, Natura l Killer (NK), Natural Killer/T (NKT), B, T regulatory cells (Treg) and T helper: T cytotoxic cells ratio were longitudinally analyzed by flow cyt...
Source: Medical Principles and Practice - September 23, 2020 Category: Internal Medicine Source Type: research

First isolation of Candida nivariensis, an emerging fungal pathogen, in Kuwait
Conclusions: This report extends the geographic distribution of C. nivariensis to the Arabian Peninsula. MALDI-TOF MS with updated software and molecular tests are needed to correctly identify C. nivariensis. Since C. nivariensis may exhibit reduced susceptibility to antifungal agents, accurate identification and antifungal susceptibility testing is essential, particularly for isolates from sterile sites, for optimal patient management. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - September 14, 2020 Category: Internal Medicine Source Type: research

Comparison of Two Single-Incision Mini-Slings for the Treatment of Incontinence
Conclusions: The present study showed that the treatment of female SUI with two different SIMS systems had similar efficacy, complication rates and scores in QoL questionnaires. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - September 10, 2020 Category: Internal Medicine Source Type: research

The positive rate of pulmonary embolism by CT pulmonary angiography is high in an emergency department —even in low-risk or young patients
Objective: The clinical presentation of pulmonary embolism (PE) can be various and misleading. We analysed patients with suspicion of PE and subsequently performed computed tomography pulmonary angiography (CTPA) in an emergency department of Internal Medicine, focusing on patient groups in which PE might be underestimated in the emergency setting, such as young patients and patients with low clinical probability. Material and Methods: In 2016 and 2017, all patients receiving a CTPA for the question of PE were retrospectively evaluated for clinical (age, symptoms, vital parameters) and D-Dimers. The Wells score was calcul...
Source: Medical Principles and Practice - September 10, 2020 Category: Internal Medicine Source Type: research

The Genetic and Clinical Significance of Fetal Hemoglobin Expression in Sickle Cell Disease
Sickle cell disease (SCD) is phenotypically heterogenic. One major genetic modifying factor is the patient ’s level of fetal hemoglobin (HbF). The latter is determined by the patient’s β-globin gene cluster haplotype and cis-acting and trans-acting single gene polymorphisms (SNP) at other distant quantitative trait loci (QTL). The Arab/India haplotype is associated with persistently high HbF levels and also a relatively mild phenotype. This haplotype carries the Xmn1 (C/T) SNP, rs 7482144 in the HBG2 locus. The major identified trans-acting QTL contain SNPs residing in the BCL11A in chromosome 2 and the HM...
Source: Medical Principles and Practice - September 4, 2020 Category: Internal Medicine Source Type: research

Personalized Immuno-oncology
In conclusion, immuno-oncology, one of the most promising approaches to management of cancer fits in well with the principles of personalized medicine. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - August 25, 2020 Category: Internal Medicine Source Type: research

Prognostic significance of red cell distribution width in idiopathic pulmonary fibrosis and combined pulmonary fibrosis emphysema
Objective: The red cell distribution width (RDW) test is an inexpensive and available prognostic indicator of various diseases. RDW has to date been assessed in only one study as a prognostic biomarker in patients with idiopathic pulmonary fibrosis (IPF), while the relationship between the RDW and combined pulmonary fibrosis emphysema (CPFE) has yet to be reported. Subject and Method: This single-center ambidirectional study was conducted between January 2015 and December 2018 in the Atat ürk Chest Diseases and Chest Surgery Education and Research Hospital. The baseline characteristics, laboratory results and surviva...
Source: Medical Principles and Practice - August 25, 2020 Category: Internal Medicine Source Type: research

Management of Type 2 Diabetes: Current Strategies, Unfocussed Aspects, Challenges and Alternatives
Type-2 diabetes mellitus (T2DM) accounts for more than 90 percent cases of diabetes in adults. Resistance to insulin action is the major cause that leads to chronic hyperglycemia in diabetic patients. T2DM is the consequence of activations of multiple pathways and factors that are involved in insulin resistance and β-cells dysfunction. Also, the etiology of T2DM involves the complex interplays between genetics and environmental factors. These interplays can be efficiently governed by lifestyle modifications to achieve a better management of diabetes. The present review aims at discussing the major factors inv olved in...
Source: Medical Principles and Practice - August 20, 2020 Category: Internal Medicine Source Type: research

Ceramic-on-Ceramic Total Hip Arthroplasty with Large Diameter Heads: A Systematic Review
Ceramic-on-ceramic (COC) total hip arthroplasties (THAs) with large heads (#x3e;36 mm) were introduced to reduce dislocation rates and restore the hip anatomy as closely as possible to the native one. To date, the literature is scarce and fragmented; a review is desirable to point out the outcomes and the possible specific complications (noise, groin pain, and taperosis). A systematic review about large-diameter COC THAs was conducted according to the PRISMA guidelines. The PubMed and Cochrane databases were searched using the terms “large”, “big”, “head”, “hip”, and “c...
Source: Medical Principles and Practice - August 5, 2020 Category: Internal Medicine Source Type: research

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Source: Medical Principles and Practice - July 28, 2020 Category: Internal Medicine Source Type: research

Clinical significance of serum Kallistatin and ENOX1 levels in patients with coronary heart disease
BACKGROUND: Kallistatin and ENOX1 are regulators of inflammation and oxidative stress which are typical pathological reactions in atherosclerosis. However, there is limited information of kallistatin and ENOX1 in CHD. METHODS: 50 healthy controls, 56 SAP patients and 47 ACS patients were included in this study. Kallistatin and ENOX1 in serum were measured by ELISA. Chi-square test was performed to analyze categorical data. ANOVA, Pearson correlation analysis, and multiple linear regression were performed to analyze the numerical data. Finally, ROC curve was applied to assess the diagnostic value of kallistatin in CHD. RE...
Source: Medical Principles and Practice - July 24, 2020 Category: Internal Medicine Source Type: research

Defining Euthanasia and the Need to be Circumspect in the Usage of the Term
Med Princ Pract (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - July 9, 2020 Category: Internal Medicine Source Type: research

Mitochondrial Haplogroup Reveals the Genetic Basis of Diabetes Mellitus Type 2 Comorbidity in Psoriasis
Objective: Published data has shown a clear link between psoriasis (Ps) and the increasing prevalence of comorbid conditions, such as diabetes mellitus type 2 (DM2). The mitochondrial genomic haplogroup's role in the potential coexistence of psoriasis and DM2 comorbidity is the subject of this study. Material and method: Ninety-eight Kuwaiti individuals were recruited in 4 cohorts (20 healthy controls (HC), 15 with DM2, 34 with psoriasis, and 29 with psoriasis and diabetes mellitus (PsDM2). An Ion Torrent S5xL was used to sequence mitochondrial DNA (mtDNA). Chi-square test (x2) was used to assess differences in the distrib...
Source: Medical Principles and Practice - July 6, 2020 Category: Internal Medicine Source Type: research

Principles of clinical ethics and their application to practice
An overview of ethics and clinical ethics is given. The 4 main ethical principles- beneficence, nonmaleficance, autonomy and justice- are defined and explained. Informed consent, truth-telling and confidentiality spring from the principle of autonomy and each of them is discussed. In patient care situations, not infrequently, there are conflicts between ethical principles (especially between beneficence and autonomy). A four-pronged systematic approach to ethical problem-solving and illustrative cases of conflicts are presented. Comments following the cases clarify the resolution of these conflicts. A model for patient car...
Source: Medical Principles and Practice - June 4, 2020 Category: Internal Medicine Source Type: research

< b > < i > ACTN3 < /i > < /b > ’s R577X Single Nucleotide Polymorphism Allele Distribution Differs Significantly in Professional Football Players according to Their Field Position
Conclusions: Genetic biomarkers may be important when analysing performance capability in elite professional football. Identifying the genetic characteristics of a player to adapt his playing position may lead to orientation of positions based on physical capabilities and tissue quality in young football players, and also to performance enhancement in those who are already playing in professional teams. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - June 3, 2020 Category: Internal Medicine Source Type: research

ACTN3 ’s R577x Single Nucleotide Polymorphism Allele Distribution Differs Significantly in Professional Football Players According to their Field Position
Conclusions: Genetic biomarkers may be important when analysing performance capability in elite professional football. Identifying the genetic characteristics of a player to adapt his playing position may lead to a position orientation based on physical capabilities and tissue quality in young football players and to performance enhancement in those who are already playing in professional teams. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - June 3, 2020 Category: Internal Medicine Source Type: research

How to reduce the potential harmful effects of light on blastocyst development during IVF
Purpose: Earlier findings revealed the damaging effect of visible light on zygotes and gametes. The aim of our study is to eliminate or significantly reduce the potential harmful effect of light exposure during in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) and to investigate the effect of light protection on embryo development and implantation. Materials/methods: To protect sperm cells, oocytes and embryos from the potential harmful effects of light exposure during laboratory procedures, we created a dark environment for the cells and applied red filters on laboratory lamps and UV or infrared filt...
Source: Medical Principles and Practice - May 29, 2020 Category: Internal Medicine Source Type: research

Beta Thalassemia Minor: Patients Are Not Tired but Depressed and Anxious
Conclusion: We found that both depression and anxiety were higher in BTm patients than in healthy individuals, but this difference was not feasible for fatigue.Med Princ Pract (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - May 27, 2020 Category: Internal Medicine Source Type: research

Beta thalassemia minor patients: not tired, but depressed and anxious
We aimed to investigate whether the severity of fatigue and the incidences of depression and anxiety of patients with beta thalassemia minor (BTm) are different than healthy individuals using Fatigue Severity Scale (FSS) and Hospital Anxiety and Depression Scale (HADS) BTm patients who were followed in University of Health Sciences Istanbul Training and Research Hospital Hematology Clinic between 2016 and 2017, who had normal biochemical parameters, thyroid function tests and C-reactive protein (CRP) levels, and didn ’t use any medications, consume alcohol or tobacco, have any chronic diseases or sleep disturbances w...
Source: Medical Principles and Practice - May 27, 2020 Category: Internal Medicine Source Type: research

Several Cases of Ocular Dirofilariasis in Bulgaria
Conclusion: The most reliable and easily accessible diagnostic method is morphological analysis by microscopy of histological preparations of the parasite. In dirofilariasis, ocular location is one of the most common cases in humans, and it deserves special attention of clinicians. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - May 27, 2020 Category: Internal Medicine Source Type: research

Prevalence of asymptomatic coronary artery stenosis based on coronary computed tomography angiography in adults with erectile dysfunction: a cross-sectional study
Objectives: To investigate the prevalence of asymptomatic coronary artery stenosis (CAS) using coronary computed tomography angiography (CCTA) in Korean men with erectile dysfunction (ED). Subjects and Methods: A cross-sectional study was conducted. Subjects were 108 men who underwent CCTA at a health promotion center in Pusan National University Yangsan Hospital. Each subject who was evaluated for ED using the International Index of Erectile Dysfunction (IIEF) questionnaire, did not have past history and symptoms of coronary artery disease. We assessed association between ED and CCTA-based CAS. Results: The overall preval...
Source: Medical Principles and Practice - May 25, 2020 Category: Internal Medicine Source Type: research

Correlation of Serum Adipolin with Epicardial Fat Thickness and Severity of Coronary Artery Diseases in Acute Myocardial Infarction and Stable Angina Pectoris Patients
Objective: Adipolin/C1q/TNF-related protein-12 is a family of CTRPs that is highly expressed in adipose tissue and has glucose-lowering and anti-inflammatory effects. Various risk factors have been suggested in the incidence of cardiovascular diseases such as a decrease in anti-inflammatory or an increase in inflammatory factors. The purpose of the present study was to investigate the correlation of adipolin with anthropometric, angiographic, echocardiographic, and biochemical parameters. Subject and Methods: A total of 90 patients who were candidates for angiography were included in the study and divided into three groups...
Source: Medical Principles and Practice - May 21, 2020 Category: Internal Medicine Source Type: research

Nocardiosis: a neglected disease
Nocardiosis is a well-read but neglected tropical disease. It has varied geographical presence and a spectrum of clinical presentations. This review aims to concentrate on national and international epidemiology of nocardial infections with a systematic approach to their diagnosis and treatment. Nocardia masquerades chronic infections and ailments, may remain cryptic but progressive in its course. Unless suspected, diagnosis can be easily missed resulting in increased morbidity and mortality. Thorough knowledge of local epidemiology, demography, clinical course and presentation, diagnostic modalities and antibiotic suscept...
Source: Medical Principles and Practice - May 18, 2020 Category: Internal Medicine Source Type: research

Association of HLA Alleles with Primary Sj ögren’s Syndrome in the South Tunisian Population
Conclusion: The results of this study support the hypothesis of the existence of a susceptibility gene for pSS loc ated in the HLA class I and III regions. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - July 5, 2019 Category: Internal Medicine Source Type: research

Cyanotic Congenital Cardiac Disease and Scoliosis: Pre-operative Assessment, Surgical Treatment and Outcomes
Conclusion: Scoliosis surgery in patients with complex cardiac disease may be indicated to treat progressive deformities which produce severe symptoms. A multidisciplinary approach including a spinal surgeon, as well as a cardiologist, haematologist, respiratory paediatrician and spinal anaesthetist can evaluate the general medical condition and weigh the benefits and risks of surgery. Deformity correction can be performed using a meticulous technique and has produced a series of satisfactory outcomes. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - July 3, 2019 Category: Internal Medicine Source Type: research

Antimicrobial Resistance Patterns in Methicillin-Resistant Staphylococcus aureus from Patients Hospitalized during 2015 - 2017 in Hospitals in Poland
Conclusion: This study demonstrates that in the hospital environment, MRSA isolates can quickly acquire new antimicrobial resistance determi nants and that knowledge of current resistance patterns is important for the effective treatment of infections caused by MDR MRSA. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - July 1, 2019 Category: Internal Medicine Source Type: research

Ultrasound-Guided Continuous Femoral Nerve Block with Dexmedetomidine Combined with Low Concentrations of Ropivacaine for Postoperative Analgesia in Elderly Knee Arthroplasty
Conclusion: The protocol of 0.05 μg × kg–1× h–1 of DEX combined with 0.15% ro ­pivacaine in ultrasound-guided continuous femoral nerve block for postoperative analgesia in elderly patients with TKA provides a better analgesic effect than without DEX performance.Med Princ Pract (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - June 28, 2019 Category: Internal Medicine Source Type: research

Coronally Repositioned Flap with Bioresorbable Collagen Membrane for Miller ’s Class I and II Recession Defects: A Case Series
Conclusion: Recession coverage with a coronally repositioned and bioresorbable collagen membrane demonstrated good results in terms of root coverage as well as increase in the width of keratinized tissue.Med Princ Pract (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - June 28, 2019 Category: Internal Medicine Source Type: research

In-vitro Post-antifungal Effect of Posaconazole and its Impact on Adhesion related Traits and Hemolysin Production of Oral Candida dubliniensis Isolates
Objective: Candidal adherence to denture acrylic surfaces (DAS) and oral buccal epithelial cells (BEC), formation of candidal germ tubes (GT), candidal cell surface hydrophobicity (CSH) and hemolysin production are important pathogenic traits of Candida. Antifungal drug-induced post-antifungal effect (PAFE) also impact the virulence of Candida. Candida dubliniensis isolates are associated with the causation of oral candidiasis which could be managed with posaconazole. Thus far there is no evidence on posaconazole-induced PAFE and its impact on adhesion-related attributes and production of hemolysin by C. dubliniensis. Henc...
Source: Medical Principles and Practice - June 28, 2019 Category: Internal Medicine Source Type: research

Clinicopathologic Features and Treatment Characteristics of Congenital Corneal Opacity Infants and Children Aged 3 Years or Less: A Retrospective Single Institution Analysis
Conclusion: Our study demonstrates that CCO has varied manifestations in infants and young children in China. A thorough medical history, careful clinical examination and the use of accessory examinations such as ultrasound biomicroscopy are critical for the accurate diagnosis and classification of CCO and to provide guidance on therapeutic choices. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - June 28, 2019 Category: Internal Medicine Source Type: research

A Formula to Predict the Magnitude of Achilles Tendon Lengthening Required to Correct Equinus Deformity
Conclusions: The required dimension of ATL can be calculated preoperatively using the mathematical formula presented here. The advantages of this approach are that it allows accurate tendon lengthening and reduces the size of the surgical incision. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - June 21, 2019 Category: Internal Medicine Source Type: research

Intravitreal Ranibizumab Injection for the Treatment of Retinopathy of Prematurity
Conclusion: One injection of 0.3 mg intravitreal ranibizumab is effective in treating ROP stage III mainly in zones I and II.Med Princ Pract (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - June 19, 2019 Category: Internal Medicine Source Type: research

Assessing HIV/AIDS Knowledge, Awareness, and Attitudes among Senior High School Students in Kuwait
Conclusion: This study provides a benchmark for further elaborate studies in the community to develop appropriate health education and awareness programs.Med Princ Pract (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - June 18, 2019 Category: Internal Medicine Source Type: research

Reply to Correspondence on “Glomerular Filtration Rate as a Prognostic Factor for Long-Term Mortality after Acute Pulmonary Embolism”
Med Princ Pract (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - June 17, 2019 Category: Internal Medicine Source Type: research

Added Value of Contrast Medium in Whole-Body Hybrid PET/MRI: Comparison Between Contrast-Enhanced and Non-Contrast-Enhanced Protocols
Objective: To compare the diagnostic ability and time efficiency of contrast-enhanced (CE) whole body FDG PET/MRI protocol and non-contrast-enhanced (NCE) protocol. Subjects and Methods: Ninety-three patients with known primary tumors underwent whole-body hybrid FDG PET/MRI during the follow-up of their malignancies with the use of NCE and CE protocols. The NCE PET/MRI protocol consisted of diffusion-weighted (b = 0 s/mm2 and 800 s/mm2) and T1-weighted Turbo Flash in the axial plane and T2-weighted HASTE sequence in the coronal planes ( ∑ = 25 minutes). The CE PET/MRI protocol was performed by acquiring axial serial CE...
Source: Medical Principles and Practice - June 17, 2019 Category: Internal Medicine Source Type: research

Laparoscopy in Acute Care Surgery: Repair of Perforated Duodenal Ulcer
Conclusions: Laparoscopy in the treatment of perforated duodenal ulcer is safe and can be utilized as a routine approach for the treatment of this pathology.Med Princ Pract (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - June 12, 2019 Category: Internal Medicine Source Type: research

Suicidal Carbon Monoxide Poisoning Using Motor Vehicle Exhaust in an Open Space
Conclusions: This case was studied to observe the pattern of fatal carbon monoxide poisoning in an open space. This might be helpful for forensic medicine, emergency medicine, and occupational medicine.Med Princ Pract (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - June 12, 2019 Category: Internal Medicine Source Type: research

Diffuse Coronary Artery Fistula Leading to Syncope and Treated with Transcatheter Coil Occlusion and a Defibrillator: A Case Report
Conclusion: The present case describes extensive fistulas complicated with fatal ventricular arrhythmias due to ischemia and left ventricle dysfunction. A cardioverter defibrillator was implanted to prevent sudden cardiac death.Med Princ Pract (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - June 12, 2019 Category: Internal Medicine Source Type: research

Perception and Attitudes of Dental Students ’ Towards Their Role in the Delivery of a Brief Smoking Cessation Intervention
Conclusions: Students need more client-centered skills and knowledge to bolster their confidence in cessation counseling. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - June 12, 2019 Category: Internal Medicine Source Type: research

NT-proBNP and Echocardiographic Parameters in Liver Cirrhosis: Correlations with Disease Severity
Conclusion: NT-proBNP is increased in patients with cirrhosis and is correlated with the severity of liver disease as established by Child-Pugh class, MELD score, and the presence of ascites.Med Princ Pract (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - June 11, 2019 Category: Internal Medicine Source Type: research

Serum Adropin Levels Are Reduced in Adult Patients with Nonalcoholic Fatty Liver Disease
Conclusion: We observed a decrease in serum adropin levels among adult patients with NAFLD. We also found lower levels of serum adropin in patients with insulin resistance, supporting previous data in the literature. Studies investigating the association of adropin levels with other inflammatory parameters are warranted to define its exact role in the pathogenesis of hepatosteatosis.Med Princ Pract (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - June 5, 2019 Category: Internal Medicine Source Type: research

Phenotypic and Genotypic Characterization of ESBL-, AmpC-, and Carbapenemase-Producing < b > < i > Klebsiella pneumoniae < /i > < /b > and < b > < i > Escherichia coli < /i > < /b > Isolates
Conclusion: In this study, 3K. pneumoniae isolates simultaneously carried ESBL, AmpC, and carbapenemase genes. Up-to-date strategies such as combination therapy or utilization of new antimicrobial agents might help to combat such drug-resistant organisms.Med Princ Pract (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - June 5, 2019 Category: Internal Medicine Source Type: research

Occlusal Caries Detection and Diagnosis Using Visual ICDAS Criteria, Laser Fluorescence Measurements and Near- İnfrared Light Transillumination Images
Objective: Current diagnostic tools for non-cavitated occlusal caries are not very reliable. For this reason, newer systems need to be developed. The aim of this study was to compare the performance of visual inspection (ICDAS-II), laser fluorescence (DIAGNOdent pen), and near-infrared transillumination technique (DIAGNOcam) in the detection of non-cavitated occlusal caries lesions under clinical and laboratory conditions in 90 third molar teeth planned for extraction. Materials and methods: Ninety third molar teeth were firstly examined in clinical conditions, scored according to ICDAS II criteria and examined with DIAGNO...
Source: Medical Principles and Practice - June 4, 2019 Category: Internal Medicine Source Type: research

Multi-Modal Intra-Operative Spinal Cord Monitoring (IOM) During Spinal Deformity Surgery: Efficacy, Diagnostic Characteristics and Algorithm Development
Conclusion: Multimodal IOM is highly sensitive and specific for spinal cord injury. This technique is reliable for the assessment of the condition of the spinal cord during major deformity surger y. We propose an algorithm of intra-operative action to allow close cooperation between the surgical, anaesthetic and neurophysiology teams and to prevent neurological deficits. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - June 4, 2019 Category: Internal Medicine Source Type: research

The utility of ocular ultrasonography to evaluate the influence of Tourniquet application on intracranial pressure
(Source: Medical Principles and Practice)
Source: Medical Principles and Practice - May 31, 2019 Category: Internal Medicine Source Type: research

Association Between Growth Differentiation Factor 15 and Non-Dipping Circadian Pattern in Patients with Newly Diagnosed Essential Hypertension
Objective: Non-dipper hypertension (HT) confers greater risk compared with dipper hypertension. Growth differentiation factor 15 (GDF-15) recently emerged as a novel and independent marker of cardiovascular disease, both in diagnostic and prognostic scopes. Our aim was to evaluate the relationship of circadian blood pressure (BP) pattern with serum GDF-15 level in newly diagnosed HT patients without left ventricular hypertrophy. Subjects and Methods: Newly diagnosed non-dipper (n = 66) and dipper (n = 60) HT patients were selected according to 24-hour ambulatory blood pressure monitoring (ABPM). Healthy normotensive subjec...
Source: Medical Principles and Practice - May 23, 2019 Category: Internal Medicine Source Type: research

Value of Multidetector Computed Tomography in the Assessment of Achalasia Subtypes and Detection of Pulmonary and Thoracic Complications
Objective: To evaluate multidetector computed tomography (MDCT) findings in patients with achalasia, to assess its role in differentiating subtypes in detecting lung involvement and extra-esophageal thoracic complications. Subjects and Methods: This clinical retrospective study included 51 patients with manometrically-confirmed achalasia who underwent chest X-ray and MDCT in diagnostic work-up. Esophageal wall thickness and morphology, luminal dilatation, lung changes and extra-esophageal manifestations were analyzed on MDCT by two readers. Wilcoxon, Kruskal-Wallis and Mann-Whitney test were used for assessing the differen...
Source: Medical Principles and Practice - May 22, 2019 Category: Internal Medicine Source Type: research

The Prognostic Impact of the Lymphocyte-to-Monocyte Ratio in Resected Pancreatic Head Adenocarcinoma < br > < br >
Objective: Although the prognostic significance of systematic inflammation-based scores, such as the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), and the prognostic nutritional index (PNI), have been explored in pancreatic cancers, few reports have investigated the lymphocyte-to-monocyte ratio (LMR). We aimed to retrospectively investigate the prognostic value of the preoperative LMR in patients with resectable pancreatic head cancer (PHC). Methods: From 2005 to 2016, 165 patients underwent pancreatoduodenectomy for PHC. All samples of peripheral blood were collected within two weeks prior ...
Source: Medical Principles and Practice - May 20, 2019 Category: Internal Medicine Source Type: research

Highly Porous Titanium Cups versus Hydroxyapatite-Coated Sockets: Mid-Term Results in Metachronous Bilateral Total Hip Arthroplasty
Conclusion: Highly porous titanium cups produced using an additive manufacturing and electron beam melting technology achieved reliable mid-term clinical and radiographic results, not inferior to second generation cups. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - May 13, 2019 Category: Internal Medicine Source Type: research

Preoperative Serum Leptin Level is Associated with Preoperative Pain Threshold and Postoperative Analgesic Consumption in Patients Undergoing Cesarean Section
Conclusion: Preoperative levels of serum leptin were higher in C-section patients with labor pain than in those without labor pain, and increased serum leptin levels were associated with decreased preoperative pain t hreshold and increased postoperative analgesic consumption in our study population. Postoperative analgesic requirements may vary among patients, and their requirements might be predicted using preoperative indicators. Serum levels of leptin might be one such indicator and this warrants further stud ies with larger sample sizes. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - April 26, 2019 Category: Internal Medicine Source Type: research