Qualitative Evaluation of α-Synuclein: A Critical Step in Unravelling the Complexities of Autism Spectrum Disorder
(Source: Medical Principles and Practice)
Source: Medical Principles and Practice - October 29, 2022 Category: Internal Medicine Source Type: research
Qualitative Evaluation of α-Synuclein – A Critical Step in Unraveling the Complexities of Autism Spectrum Disorder
α-synuclein is a widely studied biomarker in neurodevelopmental disorders such as autism spectrum disorder (ASD) and neurodegenerative diseases (termed synucleinopathies), including Alzheimer’s disease (AD), Parkinson’s disease (PD), dementia with Lewy bodies (DLBs), and multiple system atroph y. There are conflicting reports on the levels of α-synuclein in children with ASD compared to normal matched controls, with some reporting increased plasma levels and others decreased levels. Al-Mazidi, S., et al have reported that plasma Levels of α-synuclein in ASD is an indicator of disease se verity. We go a step further ...
Source: Medical Principles and Practice - October 29, 2022 Category: Internal Medicine Source Type: research
Etiology and Antibiotic Susceptibility Patterns of Urinary Tract Infections in Children in A General Hospital in Kuwait: A 5-Year Retrospective Study
Conclusion: E. coli remains the most common uropathogen. A high percentage of the uropathogens causing UTI in children w as highly resistant to the first- and second-line antibiotics for the therapy of UTI. ESBL-producing bacteria are highly prevalent in children in our hospital. Local antibiograms should be used to assist with empirical UTI treatment. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - October 29, 2022 Category: Internal Medicine Source Type: research
Risk Factors for New Onset Atrial Fibrillation During Thyroid Gland Surgery
Conclusions: Incidence of NOAF during thyroid surgery is similar to other type of surgery, if the values of thyroid hormones are normal. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - October 21, 2022 Category: Internal Medicine Source Type: research
Allergy, Anaphylaxis, and Nonallergic Hypersensitivity: IgE, Mast Cells, and Beyond
IgE-mediated type I hypersensitivity reactions have many reported beneficial functions in immune defense against parasites, venoms, toxins, etc. However, they are best known for their role in allergies, currently affecting almost one third of the population worldwide. IgE-mediated allergic diseases result from a maladaptive type 2 immune response that promotes the synthesis of IgE antibodies directed at a special class of antigens called allergens. IgE antibodies bind to type I high-affinity IgE receptors (Fc εRI) on mast cells and basophils, sensitizing them to get triggered in a subsequent encounter with the cognate all...
Source: Medical Principles and Practice - October 11, 2022 Category: Internal Medicine Source Type: research
Allergy, Anaphylaxis and Non-Allergic Hypersensitivity: IgE, Mast Cells and Beyond
IgE-mediated type I hypersensitivity reactions have many reported beneficial functions in the immune defense against parasites, venoms, toxins etc. However, they are best-known for their role in allergy affecting nowadays almost one third of the population worldwide. IgE-mediated allergic diseases result from a maladaptive type 2 immune response that promotes the synthesis of IgE antibodies directed to a special class of antigens called allergens. IgE antibodies bind to type I high affinity IgE receptors (FcepsilonRI) on mast cells and basophils licensing them to get triggered in a subsequent encounter with the cognate all...
Source: Medical Principles and Practice - October 11, 2022 Category: Internal Medicine Source Type: research
Extrahepatic Portal Vein Thrombosis in Childhood: Risk Factors, Clinical Manifestations, and Management
Conclusion: Patients with known systemic or local risk factors for EHPVT are indicated for proactive ultrasound screening for early diagnosis and timely management.Med Princ Pract (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - October 10, 2022 Category: Internal Medicine Source Type: research
Extrahepatic Portal Vein Thrombosis in Childhood: Risk factors, Clinical Manifestations and Management
Conclusion: Patients with known systemic or local risk factors for EHPVT are indicated for proact ive ultrasound screening for early diagnosis and timely management. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - October 10, 2022 Category: Internal Medicine Source Type: research
Reconsideration of the Role of Regulatory T Cells During Pregnancy: Differential Characteristics of Regulatory T Cells Between the Maternal-Fetal Interface And Peripheral Sites and Between Early and Late Pregnancy
Regulatory T (Treg) cells play an important role in embryo implantation and pregnancy maintenance after allogeneic mating. Implantation failure, miscarriage, and preeclampsia are associated with decreased Treg cell numbers or dysfunctional Treg cells. Memory naturally occurring Treg (nTreg or thymus-derived Treg (tTreg)) cells were recently reported to accumulate in the uterus during the early pregnancy period and contribute to pregnancy establishment. Miscarriage cases are characterized by the downregulation of the total Treg cell numbers rather than the downregulation of paternal/fetal antigen-specific Treg cell numbers....
Source: Medical Principles and Practice - October 4, 2022 Category: Internal Medicine Source Type: research
Trends in Imaging Patterns of Bronchogenic Carcinoma: Reality or a Statistical Variation? A Single-Center Cross-Sectional Analysis of Outcomes
Conclusion: CT is the imaging modality of choice for evaluating bronchogenic carcinoma and provides for precise characterization of the size, extent, and staging of the carcinoma. Among 162 bronchogenic carcinoma cases evaluated in the current study, a definite changing trend in the radiological pattern of squamous cell carcinoma and adenocarcinoma was observed. Squamous cell carcinoma was predominantly noted to be a peripheral tumor, and adenocarcinoma is predominantly noted to be a central tumor. Surveillance or restaging scans are recommended, considering the high mortality rate in patients with bronchogenic carcinoma.M...
Source: Medical Principles and Practice - October 4, 2022 Category: Internal Medicine Source Type: research
Trends in imaging patterns of bronchogenic carcinoma – Reality or a statistical variation? A single-center cross-sectional analysis of outcomes
Conclusion: Computed tomography is the imaging modality of choice for evaluating bronchogenic carcinoma and provides for precise characterization of the size, extent and staging. Amongst 162 bronchogenic carcinoma cases evaluated in the current study, a definite changing trend in the radiological pattern of squamous cell carcinoma and adenocarcinoma was witnessed. In the current study, squamous cell carcinoma is predominantly noted to be a peripheral tumor and adenocarcinoma is predominantly noted to be a central tumor. Surveillance or restaging scans are recommended considering the high mortality rate in patients with bro...
Source: Medical Principles and Practice - October 4, 2022 Category: Internal Medicine Source Type: research
Thrombolysis in Myocardial Infarction Risk Index Predicts One-Year Mortality in Patients with Heart Failure: An Analysis of the SELFIE-TR Study
Objective: Predicting outcomes is an essential part of evaluation in patients with heart failure (HF). While there are multiple individual laboratory and imaging variables, as well as risk scores available for this purpose, they are seldom useful during the initial evaluation. In this analysis, we aimed to understand predictive usefulness of Thrombosis in Myocardial Infarction Risk Index (TIMI-RI), a simple index that is calculated at bedside using three commonly available variables, using data from a multicenter HF registry. Subjects and Methods: A total of 728 patients from 23 centers were included to this analysis. Data...
Source: Medical Principles and Practice - September 27, 2022 Category: Internal Medicine Source Type: research
A deep-learning model for idiopathic osteosclerosis detection on panoramic radiographs
Conclusion: Deep learning-based AI algorithm have the potential to detect IOs accurately on panoramic radiographs. AI systems may reduce of dentist diagnostic efforts in the future. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - September 27, 2022 Category: Internal Medicine Source Type: research
The Role of Serum Resolvin D1 Levels in Determining the Presence and Prognosis of ST-Segment Elevation Myocardial Infarction
Conclusion: Serum Resolvin D1 levels were detected to be lower in the group with STEMI compared to the control group. Admission RvD1 levels were associated with poor prognostic markers of STEMI. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - September 21, 2022 Category: Internal Medicine Source Type: research
Factors Associated with a High-Risk Profile for Developing Pressure Injuries in Long-Term Residents of Nursing Homes
Conclusion: The pr evalence of NH residents at high risk of pressure injuries was very high using the Norton scale, but the percentage of residents who develop these ulcers is definitely lower. Female NH residents with advanced age, dementia and a history of cerebrovascular disease should be carefully monitored. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - September 19, 2022 Category: Internal Medicine Source Type: research
