List of Reviewers Vol. 31, 2022
Med Princ Pract 2022;31:596 (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - January 4, 2023 Category: Internal Medicine Source Type: research
The Association between < b > < i > Helicobacter pylori < /i > < /b > and Colorectal Neoplasia
Conclusions: We found a clustered co-occurrence of CRN andH. pylori. This association persisted after correction for shared cardiometabolic risk factors. We suggest that our analysis emphasizes the clinical value ofH. pylori eradication. Whether “test and treat”H. pylori is warranted to prevent CRN remains unclear but is at least a possibility given the simplicity of “test and treat.”Med Princ Pract (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - December 29, 2022 Category: Internal Medicine Source Type: research
The Association between < b > < i > Helicobacter pylori < /i > < /b > and Colorectal Neoplasia
Conclusions: We found a clustered co-occurrence of CRN andH. pylori. This association persisted after correction for shared cardiometabolic risk factors. We suggest that our analysis emphasizes the clinical value ofH. pylori eradication. Whether “test and treat”H. pylori is warranted to prevent CRN remains unclear but is at least a possibility given the simplicity of “test and treat.” (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - December 29, 2022 Category: Internal Medicine Source Type: research
The Association between Helicobacter pylori and Colorectal Neoplasia
Objectives: Both Helicobacter pylori (H. pylori) and colorectal neoplasia (CRN) are frequent entities in gastroenterology. Epidemiological data suggest an association between H. pylori positivity (H. pylori +) and CRN, whereas pathophysiologic considerations substantiate a possible causal relationship. However, the relationship between CRN and H. pylori+ may also be mediated by shared risk factors. Therefore, the aim of this cross-sectional study was to evaluate a possible independent relationship between H.pylori and CRN in a Central European cohort.
Methods: We included 5,707 asymptomatic patients in this study. All pat...
Source: Medical Principles and Practice - December 29, 2022 Category: Internal Medicine Source Type: research
Tei Index Complements Conventional Echocardiographic Parameters in Diagnostic Workup of Suspected Takotsubo Syndrome
Background: Tei index (TI) is a combined myocardial performance index for overall cardiac function, the sensitivity of which seems to be better than that of systolic and diastolic parameters alone. Evidence for TI in the context of Takotsubo syndrome (TTS) is currently limited, which is why we chose to investigate this parameter in affected patients. Subjects and Methods: Patients with TTS (n = 51), acute coronary syndrome (ACS; n = 29) and controls (n = 58) were retrospectively investigated. Laboratory and echocardiographic parameters including TI were analyzed for their ability to discriminate TTS in the total study coho...
Source: Medical Principles and Practice - December 26, 2022 Category: Internal Medicine Source Type: research
The SCN5A Gene Is a Predictor of Phenotype Severity in Brugada Syndrome: A Comprehensive Literature Review
Conclusion: In this review, we show how the SCN5A mutation status predicts phenotypic characteristics and prognosis in patients with BrS. We conclude that SCN5A mutations weakly predict greater malignant arrhythmic event risk in BrS patients. However, SCN5A mutations do not show robust enough associations with severity indicators to be an independent part of current risk stratification strategies. With advancing knowledge of BrS genetics, the integration of data on rare variants of SCN5A and polygenic risk scores could make an impact on clinical decision-making. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - November 29, 2022 Category: Internal Medicine Source Type: research
The SCN5A gene is a phenotype severity predictor in Brugada syndrome – a comprehensive literature review
Conclusion: In this review, we show how the SCN5A mutation status predicts phenotypic characteristics and prognosis in patients with BrS. We conclude that SCN5A mutations weakly predict greater malignant arrhythmic event risk in BrS patients. However, SCN5A mutations do not show robust enough associations with severity indicators to be an independent part of current risk stratification strategies. With advancing knowledge of BrS genetics, the integration of data on rare variants of SCN5A and polygenic risk scores could make an impact on clinical decision making. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - November 29, 2022 Category: Internal Medicine Source Type: research
Nuclear Factor- κB Clinical Significance in Breast Cancer: An Immunohistochemical Study
Objectives: Nuclear factor κB (NF-κB) is a superfamily of transcription factors that plays a key role in cancer genesis and progression. The present study aimed to explore the exact role of NF-κB/p65 as a marker in breast cancer and its relationship with other prognostic markers, such as tumour grade, tumour size, hormone receptors, and HER-2 expression. Methods: Ninety-nine unselected formalin-fixed paraffin-embedded invasive ductal and lobular tissue sections were evaluated by immunohistochemistry methods to measure NF-κB/p65 expression, ER, PR, HER-2 and Ki-67. The correlation between NF-κB/p65 and clinicopathol og...
Source: Medical Principles and Practice - November 22, 2022 Category: Internal Medicine Source Type: research
Association of the bioimpedance phase angle and quality of life in postmenopausal osteoporosis
Objectives: Osteoporosis patients with fragility fractures and vertebral deformities have impaired quality of life (QOL). The phase angle is an index calculated from bioelectrical impedance analysis (BIA) measurements that has been reported to be related to clinical outcomes, mortality, and QOL in various diseases. The aim was to investigate the relationship between the phase angle and QOL in patients with postmenopausal osteoporosis. Methods: A total of 81 female patients treated for postmenopausal osteoporosis from September 2019 to March 2020 underwent measurement of bone mineral density (BMD) by dual-energy X-ray absor...
Source: Medical Principles and Practice - November 10, 2022 Category: Internal Medicine Source Type: research
Impact of Preoperative Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios on Long-Term Survival in Patients with Operable Pancreatic Ductal Adenocarcinoma
Conclusions: NLR and PLR measurements cannot provide important prognostic results in patients with resectable PDAC. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - November 2, 2022 Category: Internal Medicine Source Type: research
Impact of Preoperative Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios on Long Term Survival in Patients with Operable Pancreatic Ductal Adenocarcinoma
The objective of study was to identify whether the preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are associated with the prognosis of PDAC of the pancreas head after curative pancreato-duodenectomy.
Materials and methods: Seventy-six patients were enrolled in this prospective observational clinical study. The optimal NLR and PLR cut-off values were calculated using a receiver operating characteristic (ROC) curve analysis. ROC curve analysis revealed an optimal NLR and PLR cut-off point of 5.41 and 205.56 respectively. Consequently, the NLR and PRL scores were classified as NLR (S...
Source: Medical Principles and Practice - November 2, 2022 Category: Internal Medicine Source Type: research
Retraction Statement
Med Princ Pract (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - November 1, 2022 Category: Internal Medicine Source Type: research
Relationship between the Atherogenic Index of Plasma and Nondipping Circadian Pattern in Hypertensive Patients
Conclusion: AIP levels are higher in patients with nondipping pattern compared to dipper patients. Additionally, higher levels of AIP are independently associated with the presence of the nondipping pattern in hypertensive patients.Med Princ Pract (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - October 31, 2022 Category: Internal Medicine Source Type: research
Relationship between the Atherogenic Index of Plasma and Non-dipping Circadian Pattern in Hypertensive Patients
Background: Hypertension is considered a major cause for the presence of cardiovascular diseases. Many studies have pointed out that the atherogenic index of plasma (AIP), which demonstrates plasma atherogenicity, is correlated with all-cause mortality, cardiovascular morbidity, atherosclerosis, and severity of coronary artery disease. Within this context, we tried to evaluate the correlation between non-dipping circadian pattern and AIP. Methods: We enrolled 1030 hypertensive patients (mean age: 53.6 ± 11.4) in total as part of the target population, who are separated into two different groups considering the circadian b...
Source: Medical Principles and Practice - October 31, 2022 Category: Internal Medicine Source Type: research
