General Information
(Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - November 1, 2023 Category: Internal Medicine Source Type: research
Highlights From the Current Issue – Audiovisual Summary
Karl A. Nath, MBChB, Editor-in-Chief of Mayo Clinic Proceedings, discusses the Editor ’s Choice and Highlights articles appearing in the November 2023 issue. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - November 1, 2023 Category: Internal Medicine Authors: Karl A. Nath Tags: Issue summary Source Type: research
Life ’s Essential 8 and Life’s Simple 7 in Relation to Coronary Atherosclerosis: Results From the Population-Based SCAPIS Project
To examine the associations between the American Heart Association scores ( “Life’s Essential 8” [LE8] and “Life’s Simple 7” [LS7]) and 2 subclinical coronary atherosclerosis indicators: coronary computed tomographic angiography (CCTA)-stenosis and coronary artery calcium (CAC). (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - October 14, 2023 Category: Internal Medicine Authors: Ángel Herraiz-Adillo, Sara Higueras-Fresnillo, Viktor H. Ahlqvist, Daniel Berglind, Maria B. Syrjälä, Bledar Daka, Cecilia Lenander, Johan Sundström, Francisco B. Ortega, Carl-Johan Östgren, Karin Rådholm, Pontus Henriksson Tags: Original Article Source Type: research
Obesity: A Review of Pathophysiology and Classification
Obesity is a chronic, multifactorial, and morbid disease. In the United States, 69% of adults are overweight or have obesity, and the global prevalence of obesity is increasing. Obesity is influenced by genetic, neurologic, metabolic, enteric, and behavioral processes. It remains a key modifiable risk factor for many comorbid diseases, including cardiovascular disease, diabetes mellitus, and cancer. Whereas there are recent and significant advances in obesity therapy, including diets, lifestyle modifications, pharmacotherapies, endoscopic procedures, and bariatric surgeries, there is an immense need for a better understand...
Source: Mayo Clinic Proceedings - October 11, 2023 Category: Internal Medicine Authors: Bradley Busebee, Wissam Ghusn, Lizeth Cifuentes, Andres Acosta Tags: Review Source Type: research
Shock Severity Classification and Mortality in Adults With Cardiac, Medical, Surgical, and Neurological Critical Illness
To evaluate whether the Society for Cardiovascular Angiography and Interventions (SCAI) Shock Classification could perform risk stratification in a mixed cohort of intensive care unit (ICU) patients, similar to its validation in patients with acute cardiac disease. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - October 8, 2023 Category: Internal Medicine Authors: Jacob C. Jentzer, Devang Senghavi, Parag C. Patel, Anirban Bhattacharyya, Sean van Diepen, Vitaly Herasevich, Ognjen Gajic, Kianoush B. Kashani Tags: Original article Source Type: research
Fatty Liver Change in Older Adults as an Important Risk Factor for Type 2 Diabetes: A Nationwide Cohort Study
To examine the association between changes in fatty liver disease (FLD) over time and the risk of type 2 diabetes in elderly individuals with prediabetes. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - October 6, 2023 Category: Internal Medicine Authors: Kye-Yeung Park, Jung Hwan Park, Kyungdo Han, Sung Hoon Yu, Chang Beom Lee, Dong Sun Kim, Hoon-Ki Park, Hwan-Sik Hwang, Sangmo Hong Tags: Original Article Source Type: research
Mayo Clinic Consensus Report on Membranous Nephropathy: Proposal for a Novel Classification
Membranous nephropathy (MN) is a pattern of injury caused by autoantibodies binding to specific target antigens, with accumulation of immune complexes along the subepithelial region of glomerular basement membranes. The past 20 years have brought revolutionary advances in the understanding of MN, particularly via the discovery of novel target antigens and their respective autoantibodies. These discoveries have challenged the traditional classification of MN into primary and secondary forms. At least 14 target antigens have been identified, accounting for 80% –90% of cases of MN. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - October 5, 2023 Category: Internal Medicine Authors: Sanjeev Sethi, Laurence H. Beck, Richard J. Glassock, Mark Haas, An S. De Vriese, Tiffany N. Caza, Elion Hoxha, G érard Lambeau, Nicola M. Tomas, Benjamin Madden, Hanna Debiec, Vivette D. D’Agati, Mariam P. Alexander, Hatem Amer, Gerald B. Appel, Sean Tags: Consensus Recommendations Source Type: research
Primary and Secondary Diagnoses in Medicine: Insights From Mayo Clinic Consensus Report on Membranous Nephropathy--Executive Summary
Broadly considered, diagnoses designated as either primary or secondary in medicine are used in at least 4 different contexts. First, this designation may be used in the Clinical Impression/Report/Plan to differentiate the most salient diagnosis from those that are less so. Second, primary may be applied to diseases arising from a genetic abnormality (eg, polycythemia, immune deficiency diseases). Third, primary may specify the original site of a particular malignant neoplasm, with secondary indicating metastases to other organs. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - October 5, 2023 Category: Internal Medicine Authors: Karl A. Nath, Lori A. Erickson, Vesna D. Garovic Tags: Commentary Source Type: research
Community Health Partners in Unexpected Places
Overcoming barriers to accessing health services is especially difficult in minority groups and rural populations. Nontraditional sites for delivering health care in the United States offer opportunities to reduce health disparities. Actually realizing these reductions, however, requires health systems to partner with trusted, convenient community services where people who experience health disparities spend substantial time — and, in turn, for those trusted service sites to seek partnerships with health systems. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - October 4, 2023 Category: Internal Medicine Authors: Michael K. Hole, Sunjay Letchuman, Allister Chang, Leonard L. Berry Tags: Special article Source Type: research
Using Augmented Mean Arterial Pressure to Identify High Mortality Risk Patients With Moderate Aortic Stenosis
To study the usefulness of a novel echocardiographic marker, augmented mean arterial pressure (AugMAP = [(mean aortic valve gradient + systolic blood pressure) + (2 × diastolic blood pressure)] / 3), in identifying high-risk patients with moderate aortic stenosis (AS). (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - October 1, 2023 Category: Internal Medicine Authors: Chieh-Ju Chao, Pradyumma Agasthi, Marlene Girardo, Timothy Barry, Amith R. Seri, Lisa Brown, Rachel E. Wraith, Anusha Shanbhag, Yuxiang Wang, Yi-Chieh Chen, Steven J. Lester, Said Alsidawi, William K. Freeman, Tasneem Z. Naqvi, Mackram Eleid, David Fortui Tags: Original article Source Type: research
44-Year-Old Woman With Cough and Shortness of Breath
A 44-year-old woman with a body mass index (BMI) of 36 kg/m2, hypertension, depression, and previous gastric banding presented to the emergency department for persistent dry cough, dyspnea, and myalgias. A recent evaluation at her local emergency department confirmed COVID-19 pneumonia by polymerase chain reaction (PCR) and chest imaging (chest x-ray [CXR], computed tomography [CT] angiography) without coexisting pulmonary embolism (PE). Following 2 visits to the emergency department, she was treated conservatively. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - October 1, 2023 Category: Internal Medicine Authors: James F. Howick V, David M. Harmon, Robert D. McBane Tags: Residents ’ clinic Source Type: research
91-Year-Old Woman With Hyperkalemia
A 91-year-old woman presented to the clinic with nighttime delirium and dysuria. The patient's medical history was provided by the patient and her daughter. Her medical history was significant for coronary artery disease, heart failure with preserved ejection fraction, hypertension, hyperlipidemia, obstructive sleep apnea, hypothyroidism, chronic kidney disease (CKD) stage 3b, chronic constipation, and depression. Her medications included levothyroxine, paroxetine, melatonin, cyanocobalamin, as-needed loratadine, and as-needed polyethylene glycol. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - October 1, 2023 Category: Internal Medicine Authors: Yuan Yao, Hadiyah Y. Audil, Christopher A. Aakre Tags: Residents ’ clinic Source Type: research
56-Year-Old Man With Hiccups
A 56-year-old man presented to the emergency department for a 5-day history of persistent hiccups. He had never experienced this problem before. The hiccups had been causing him significant distress. He had not slept during this time, and he expressed significant frustration with the hiccups ’ interference with daily activities including eating, drinking, and speaking. He endorsed associated symptoms of mild chest pain and abdominal pain with 1/10 intensity which he attributed to muscle soreness from the hiccups, as well as belching more than usual since the hiccups began. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - October 1, 2023 Category: Internal Medicine Authors: Tyler A. Bahr, Derick D. Jones Tags: Residents ’ clinic Source Type: research
Nail Changes in a Patient With Cancer
A man in his 30s with adenoid cystic carcinoma of the lung presented with nail changes of several months ’ duration. Chemotherapy with docetaxel and cisplatin was initiated for tumor recurrence, and nail changes developed 5 months later. Skin examination revealed onycholysis, splinter hemorrhage, and subungual hyperkeratosis on the fingernails with Beau lines and melanonychia on the toenails (Figure) . There were no symptoms of peripheral neuropathy. Fungal culture yielded negative results. Chemotherapy-associated nail changes were diagnosed and the patient was treated with topical emollients. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - October 1, 2023 Category: Internal Medicine Authors: Po-Chien Wu, Jennifer Wu, Yi-Teng Hung Tags: Medical image Source Type: research
Idiopathic Familial Acro-osteolysis
A man in his 40s and his child presented to our hospital with complaints of weakness and pain in their fingers and feet for the previous 3 years. A physical examination revealed massive osteolysis of the parent and a number of mildly clubbed fingers in the child. The results of tests for antinuclear antibody (titer, 1:1280), anti –double-stranded DNA, antiribonucleoprotein, and anti-Scl-70 antibodies were negative. Radiographs of the parent showed sharply demarcated osteolysis of the middle and distal phalanges of the fingers on both hands and the feet (Figure A, B). (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - October 1, 2023 Category: Internal Medicine Authors: Xinru Ba, Guowei Zhang, Hao Guo Tags: Medical image Source Type: research
