Facial Nerve Palsy After Chimeric Antigen Receptor T-Cell Therapy
A man in his 60s with relapsed/refractory IgG lambda multiple myeloma underwent chimeric antigen receptor T (CART) cell therapy. Twenty-five days after infusion, he presented with new right-sided facial numbness. Physical examination showed right-sided facial paralysis (Figure 1). A magnetic resonance image of the brain with and without contrast enhancement showed new increased enhancement of the bilateral facial nerves (Figure 2). Despite bilateral enhancement on imaging, clinically his facial palsy manifested unilaterally to the right side. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - October 1, 2023 Category: Internal Medicine Authors: Alexis B. Richards, Geoffrey P. Fletcher, Javier L. Munoz Tags: Medical image Source Type: research
Association of Mild-to-Moderate Aortic Regurgitation With Outcomes in Heart Failure With Preserved Ejection Fraction
To assess aortic regurgitation (AR) prevalence, its hemodynamic effect, and long-term prognostic implications in patients admitted with de novo or worsened heart failure with preserved ejection fraction (HFpEF). (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - October 1, 2023 Category: Internal Medicine Authors: Cristina De Colle, Pasquale Paolisso, Emanuele Gallinoro, Dario Tino Bertolone, Niya Mileva, Davide Fabbricatore, Chiara Valeriano, Robert Herman, Monika Beles, Elayne Kelen De Oliveira, Costantino Mancusi, Ward Heggermont, Carlos Collet, Marc Vanderheyde Tags: Original article Source Type: research
Probable Parasomnias and Mortality: A Prospective Study in US Men
To examine the association between parasomnias, including rapid eye movement sleep behavior disorder (RBD) and sleep walking (SW), and mortality risk in a large-scale population-based cohort. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - October 1, 2023 Category: Internal Medicine Authors: Xinyuan Zhang, Samantha A. Molsberry, Milena Pavlova, Michael A. Schwarzschild, Alberto Ascherio, Xiang Gao Tags: Original article Source Type: research
Revolution or Peril? The Controversial Role of Large Language Models in Medical Manuscript Writing
The rapid development of artificial intelligence (AI) has given rise to a new era in medical writing, as AI-powered tools called large language models (LLMs) are now available to generate text based on user prompts. Is the rise of AI in medical manuscript writing ethical and effective? No matter where you stand, this debate is taking the scientific community by storm. This emerging technology has potential implications across various areas of medicine, from research reporting to scholarly manuscript preparation. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - October 1, 2023 Category: Internal Medicine Authors: Ricardo Diaz Milian, Pablo Moreno Franco, William D. Freeman, John D. Halamka Tags: Commentary Source Type: research
PAX8-Positive (Gynecologic-Type) Clear Cell Carcinoma Metastatic to the Kidney
A woman in her late 60s presented with a 3.2-cm mass involving both the liver and the right kidney. Histopathologic evaluation showed the presence of a tumor with clear cytoplasm (Figure 1A) that was diffusely positive for the paired box 8 (PAX8) transcription factor, which is frequently used to establish renal histogenesis (Figure 1B). Although the presence of a PAX8-positive tumor with clear cytoplasm suggested a clear cell renal cell carcinoma that was primary to the kidney, t his tumor had some unusual morphologic features. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - October 1, 2023 Category: Internal Medicine Authors: Sounak Gupta, Amy A. Swanson, Lori A. Erickson Tags: Path to patient image quiz Source Type: research
5-Lead Electrocardiogram Monitoring to Detect Perioperative Myocardial Infarction, Noncardiac Surgery Patients
Perioperative myocardial infarction (MI) can have a mortality rate upward of 25%. The 5-lead electrocardiogram (ECG) is one of the standard basic anesthesia monitors.1 The V5 lead is the most sensitive lead of the ECG for detecting MI.2 The diagnosis of MI usually requires an elevation in the cardiac troponin concentrations above the 99th percentile with a rising or falling pattern accompanied by clinical evidence of acute myocardial ischemia. We hypothesize that 5-lead ECG ST analysis has low sensitivity and specificity for MI in noncardiac surgery. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - October 1, 2023 Category: Internal Medicine Authors: Gregory A. Nuttall, Michael P. Merren, Yader Sandoval Tags: Letter to the editor Source Type: research
Diagnosis and Management of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic neurologic disease often preceded by infection. There has been increased interest in ME/CFS recently because of its significant overlap with the post-COVID syndrome (long COVID or post-acute sequelae of COVID), with several studies estimating that half of patients with post-COVID syndrome fulfill ME/CFS criteria. Our concise review describes a generalist approach to ME/CFS, including diagnosis, evaluation, and management strategies. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - October 1, 2023 Category: Internal Medicine Authors: Stephanie L. Grach, Jaime Seltzer, Tony Y. Chon, Ravindra Ganesh Tags: Concise review for clinicians Source Type: research
Folk Fantail, Missing you-Kotare, Sunshine Kereru, Loyal Hihi, and Morning Quails by Jane Galloway
Art is integrated into the Mayo Clinic environment. Since the original Mayo Clinic Building was finished in 1914, many pieces have been donated or commissioned for patients and staff to enjoy. Each issue of Mayo Clinic Proceedings features a work of art (as interpreted by the author) that is displayed in a building or on the grounds of Mayo Clinic campuses. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - October 1, 2023 Category: Internal Medicine Authors: Margaret R. Wentz Tags: Art at mayo clinic Source Type: research
Sleepwalking Into a Risky Path: Expanding the Concerns for Parasomnias in the Elderly
Parasomnias are abnormal behaviors occurring during sleep. In older adults, rapid eye movement (REM) sleep behavior disorder (RBD) is the most common parasomnia, with a community prevalence of approximately 1% to 2% using polysomnography (PSG)1 and 7% to 13% using questionnaires.2,3 It is characterized by dream enactment behaviors (eg, yelling, punching, kicking) in the setting of loss of normal atonia during REM sleep, which can lead to injury to patients and their bed partners.4 It is well recognized that RBD is a harbinger of neurodegeneration secondary to accumulation of α-synuclein, increasing the risk for future dev...
Source: Mayo Clinic Proceedings - October 1, 2023 Category: Internal Medicine Authors: Diego Z. Carvalho, Erik K. St. Louis Tags: Editorial Source Type: research
Obesity: Central Role in Heart Failure With Preserved Ejection Fraction?
The prevalence and incidence of heart failure with preserved ejection fraction (HFpEF) have steadily risen during the past 10 years, especially in the United States. About half of heart failure (HF) diagnoses are HFpEF, with a prevalence of 1% each year.1 In addition, it remains an important public health issue as HF care is projected to cost $69.8 billion by 2030.1 Mortality in HFpEF also remains substantial, with a recent estimate of 33.3% 1-year mortality in patients hospitalized for acute decompensated HFpEF. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - October 1, 2023 Category: Internal Medicine Authors: Megan Pelter, Tamara Horwich Tags: Editorial Source Type: research
In the Limelight: October 2023
This month ’s feature highlights three articles that appear in the current issue of Mayo Clinic Proceedings. These articles are also featured on the Mayo Clinic Proceedings’ YouTube Channel (https://youtu.be/JTG1BYMSjuY). (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - October 1, 2023 Category: Internal Medicine Authors: Karl A. Nath Tags: In the limelight Source Type: research
Editorial Board
(Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - October 1, 2023 Category: Internal Medicine Source Type: research
Table of Contents
(Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - October 1, 2023 Category: Internal Medicine Source Type: research
General Information
(Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - October 1, 2023 Category: Internal Medicine Source Type: research
Highlights From the Current Issue – Audiovisual Summary
Karl A. Nath, MBChB, Editor-in-Chief of Mayo Clinic Proceedings, discusses the Editor ’s Choice and Highlights articles appearing in the October 2023 issue. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - October 1, 2023 Category: Internal Medicine Authors: Karl A. Nath Tags: Issue summary Source Type: research
