In Utero and Childhood/Adolescence Exposure to Tobacco Smoke, Genetic Risk, and Cancer Incidence in Adulthood: A Prospective Cohort Study
To evaluate the association of early-life tobacco smoke exposure, especially interacting with cancer genetic variants, with adult cancer. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - July 7, 2023 Category: Internal Medicine Authors: Heng He, Qian Shen, Ming-ming He, Weihong Qiu, Haoxue Wang, Shanshan Zhang, Shifan Qin, Zequn Lu, Ying Zhu, Jianbo Tian, Jiang Chang, Kai Wang, Xuehong Zhang, Xiaoping Miao, Mingyang Song, Rong Zhong Tags: Original Article Source Type: research
Association Between Glucosamine Use and the Risk of Incident Heart Failure
To evaluate the association between regular glucosamine intake and heart failure (HF) and to explore whether the association is mediated by relevant cardiovascular disease. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - July 7, 2023 Category: Internal Medicine Authors: Jiazhen Zheng, Daniel Nyarko Hukportie, Yingchai Zhang, Jinghan Huang, Can Ni, Gregory Y.H. Lip, Shaojun Tang Tags: Original article Source Type: research
The Association Between Thyroid Stimulating Hormone and Depression
To investigate the association between thyroid-stimulating hormone (TSH) and clinically relevant depression (CRD) in a population-based study. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - July 1, 2023 Category: Internal Medicine Authors: Rakesh Kumar, Allison M. LeMahieu, Marius N. Stan, Ashok Seshadri, Aysegul Ozerdem, Vanessa K. Pazdernik, Tara L. Haynes, David H. Daugherty, Vishnu Sundaresh, Marin Veldic, Paul E. Croarkin, Mark A. Frye, Balwinder Singh Tags: Original article Source Type: research
Management of Premature Ventricular Complexes in the Outpatient Setting
With an aging population and an explosion in ambulatory electrocardiographic monitoring, primary care clinicians will undoubtedly see an increase in patients presenting with premature ventricular complexes (PVCs), especially given how common they are in the general population. A sizable number of patients with PVCs are asymptomatic, and these PVCs have no significant clinical implications. In contrast, PVCs can predispose patients to or are a clinical marker of an underlying cardiomyopathy, heart failure, or sudden cardiac death. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - July 1, 2023 Category: Internal Medicine Authors: Andrew S. Tseng, Gurukripa N. Kowlgi, Christopher V. DeSimone Tags: Review Source Type: research
SGLT2 Inhibitors Are Associated With Reduced Cardiovascular Disease in Patients With Type 2 Diabetes
To assess the association between sodium-glucose cotransporter-2 (SGLT2) inhibitors and other second-line diabetes therapies with risk of cardiovascular disease (CVD), as well as conduct head-to-head comparisons between SGLT2 inhibitors. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - July 1, 2023 Category: Internal Medicine Authors: Wendy Wang, Lin Yee Chen, Rob F. Walker, Lisa S. Chow, Faye L. Norby, Alvaro Alonso, James S. Pankow, Pamela L. Lutsey Tags: Original article Source Type: research
Contemporary Use of Ticagrelor vs Clopidogrel in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention
To evaluate potential gains in outcomes from ticagrelor-based strategy according to risk stratification by Global Registry of Acute Coronary Events (GRACE) score. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - July 1, 2023 Category: Internal Medicine Authors: Miaohan Qiu, Kun Na, Zizhao Qi, He Zhou, Pengxiao Li, Kai Xu, Bin Wang, Haiwei Liu, Jing Li, Yi Li, Yaling Han Tags: Original article Source Type: research
Progressive Orthopnea and Bendopnea Due to Diaphragmatic Paralysis Associated With IgLON5 Autoimmunity
A man in his late 60s presented with a 2-year history of rapid eye movement behavioral disorder (RBD), progressive dyspnea, and orthopnea. He also reported marked shortness of breath when he bent over (bendopnea).1 He had vocal cord paralysis 11 years ago. Neurological examination revealed right deltoid fasciculations. Deep tendon reflexes were brisk. Babinski sign was absent. Thorough cardiac work-up including echocardiography was unremarkable. Because of the presence of brisk reflexes, fasciculations, and progressive dyspnea, the patient was referred for evaluation of motor neuron disease (MND). (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - July 1, 2023 Category: Internal Medicine Authors: Smathorn Thakolwiboon, Christopher J. Klein, Divyanshu Dubey Tags: Medical image Source Type: research
Rising Rates of Suicidal Behaviors and Large Unmet Treatment Needs Among US Adults With a Major Depressive Episode, 2009 to 2020
To examine recent 12-year trends in the incidence of suicidal ideation (SI) and suicide attempts (SAs) and receipt of mental health treatment among individuals experiencing a past-year major depressive episode (MDE). (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - July 1, 2023 Category: Internal Medicine Authors: Tanner J. Bommersbach, Robert A. Rosenheck, Taeho Greg Rhee Tags: Original article Source Type: research
HES and EGPA
Elevated eosinophil counts are implicated in multiple diseases, from relatively prevalent organ-specific disorders such as severe eosinophilic asthma, to rare multisystem disorders such as hypereosinophilic syndrome (HES) and eosinophilic granulomatosis with polyangiitis (EGPA). Patients with these multisystem diseases, often associated with markedly elevated eosinophil counts, have a substantial risk of morbidity and mortality due to delayed diagnosis or inadequate treatment. A thorough workup of symptomatic patients presenting with elevated eosinophil counts is essential, although in some cases the differential diagnosis...
Source: Mayo Clinic Proceedings - July 1, 2023 Category: Internal Medicine Authors: Paneez Khoury, Praveen Akuthota, Namhee Kwon, Jonathan Steinfeld, Florence Roufosse Tags: Review Source Type: research
Risk of Chronic Systemic Inflammation and Disease Disparities in the LGBTQ+ Community
We have endured a seemingly ever-expanding chronic disease health crisis over the last several decades. While the coronavirus disease 2019 (COVID-19) pandemic transiently lessened the world ’s focus on chronic disease prevention and management, the chronic disease health crisis remains. In fact, the increase in unhealthy lifestyle behaviors during the COVID-19 pandemic may ultimately further accelerate chronic disease incidence and prevalence. We have known for some time that dispari ties exist in health trajectory and chronic disease risk, with underserved communities and under-represented individuals bearing a far grea...
Source: Mayo Clinic Proceedings - July 1, 2023 Category: Internal Medicine Authors: Ross Arena, Annamaria Arena Tags: Perspective and controversy Source Type: research
Skin Cancer Associated With Chronic Leg Ulcers in the Population of Olmsted County, Minnesota
Malignant skin tumors in the setting of chronic leg ulcers (CLUs) are often underdiagnosed which may contribute to treatment delay and poor outcomes. The aims of our study were to determine the incidence and clinical characteristics of skin cancers in leg ulcers in the Olmsted County population from 1995 to 2020. We used the Rochester Epidemiology Project (a collaboration between health care providers) infrastructure to describe this epidemiology, allowing “population-based” research. Electronic medical records of adult patients with International Classification of Diseases diagnosis codes for leg ulcers and skin cance...
Source: Mayo Clinic Proceedings - July 1, 2023 Category: Internal Medicine Authors: Gina R. Chacon Osorio, Saranya P. Wyles, Nneka I. Comfere, Paul Y. Takahashi, Jennifer M. Manggaard, Karen M. Fischer, Heather N. Jett, Abhinav Singla, Nahid Y. Vidal Tags: Brief report Source Type: research
Takayasu Arteritis
A 50-year-old man presented for a second opinion regarding management of a recently diagnosed ascending aorta aneurysm. He had history of cutaneous psoriasis, gout, and recurrent sinus infections. He had no complaints, and physical examination was unremarkable. He was recently treated for an acute episode of sinusitis with a 10-day course of prednisone and doxycycline. His C-reactive protein level decreased from 120 mg/dL to 31 mg/dL (normal: ≤8.0 mg/L) but did not fully normalize after treatment. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - July 1, 2023 Category: Internal Medicine Authors: Fatima M. Ezzeddine, Philip D. Hurst, Candice A. Bookwalter Tags: Medical image Source Type: research
Bullous Systemic Lupus Erythematosus With Lupus Nephritis
A young woman with systemic lupus erythematosus on hydroxychloroquine, mycophenolate mofetil, and prednisone presented to the dermatology clinic with a 3-week history of a bullous eruption involving the face, oral mucosa, elbows, and hands (Figure 1). A skin biopsy with direct immunofluorescence revealed a neutrophil-rich subepidermal vesiculobullous dermatitis and linear deposition of immunoglobulin G (IgG), IgM, IgA, and fibrinogen at the basement membrane zone, consistent with bullous systemic lupus erythematosus (BSLE) (Supplemental Fig ure, available online at http://www.mayoclinicproceedings.org). (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - July 1, 2023 Category: Internal Medicine Authors: Meryl Musicante, Whitney Shroyer, Mariantonieta Tirado Tags: Medical image Source Type: research
Post-COVID Conditions
Postinfectious syndromes have been described since the Spanish influenza pandemic of 1918. A similar syndrome —post-COVID condition (PCC)—is common; it occurs months after COVID-19 infection and involves fatigue, postexertional malaise, dyspnea, memory loss, diffuse pain, and orthostasis. The medical, psychosocial, and economic impact of PCC is immense. In the United States, PCC has caused widespread un employment and billions in lost wages. Risk factors for development of PCC are female sex and severity of acute COVID-19 infection. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - July 1, 2023 Category: Internal Medicine Authors: Michael R. Mueller, Ravindra Ganesh, Ryan T. Hurt, Thomas J. Beckman Tags: Concise review for clinicians Source Type: research
Skilled Health Workforce Emigration
Trained and equitably distributed health workers are the foundation for effective and sustainable health systems. The World Health Organization (WHO) developed the Global Strategy on Human Resources for Health: Workforce 2030 with an aim to accelerate progress towards universal health coverage and the United Nations Sustainable Development Goals.1 To meet the targets for universal health coverage, the world needs at least 43 million additional health workers.2 The most acute health workforce shortages are in sub-Saharan Africa, South Asia, North Africa, and the Middle East. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - July 1, 2023 Category: Internal Medicine Authors: Rohina Joshi, Kenneth Yakubu, Vikash Ranjan Keshri, Vivekanand Jha Tags: Commentary Source Type: research
