Facial Nerve Palsy After Chimeric Antigen Receptor T-Cell Therapy

A man in his 60s with relapsed/refractory IgG lambda multiple myeloma underwent chimeric antigen receptor T (CART) cell therapy. Twenty-five days after infusion, he presented with new right-sided facial numbness. Physical examination showed right-sided facial paralysis (Figure  1). A magnetic resonance image of the brain with and without contrast enhancement showed new increased enhancement of the bilateral facial nerves (Figure 2). Despite bilateral enhancement on imaging, clinically his facial palsy manifested unilaterally to the right side.

Source: Mayo Clinic Proceedings - October 1, 2023 Category: Internal Medicine Authors: Alexis B. Richards, Geoffrey P. Fletcher, Javier L. Munoz Tags: Medical image Source Type: research