The Imperative of Clinical Trial Diversity: Lessons From the SARS-CoV-2 Pandemic
The National Academy of Science, Engineering, and Medicine recently published a report on the lack of diversity in clinical trials.1 This concern, highlighting the importance of research equity, proved especially relevant during the COVID-19 pandemic. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 1, 2024 Category: Internal Medicine Authors: Amanda Sinderovsky, Eli Y. Adashi Tags: Letter to the Editor Source Type: research
Eosinophilic Esophagitis: Clinical Pearls for Primary Care Providers and Gastroenterologists
Eosinophilic esophagitis (EoE) is a chronic and progressive immune-mediated esophageal disorder. Given its increasing incidence, it is now a leading cause of dysphagia and food impaction in the United States. Eosinophilic esophagitis is most common in adult White men and has a high concurrence rate with other atopic conditions like allergic rhinitis, bronchial asthma, and eczema. The initial presentation includes symptoms of esophageal dysfunction, classically solid-food dysphagia. Without treatment, inflammation can progress to fibrosis with the formation of strictures, leading to complications such as food impaction. (So...
Source: Mayo Clinic Proceedings - April 1, 2024 Category: Internal Medicine Authors: Rohit Goyal, Amrit K. Kamboj, Diana L. Snyder Tags: Concise Review Source Type: research
Secondary Involvement of the Urinary Bladder by Endometrial Carcinoma
A woman in her late 50s presented with pelvic pain and on transvaginal ultrasound examination was noted to have a bladder mass. Cystoscopy revealed the presence of a 6.0-cm mass, which was resected. Histopathologic examination revealed the presence of a glandular neoplasm underlying the surface urothelium (Figure 1A, B). No evidence of a precursor urothelial neoplasm, such as urothelial carcinoma in situ or papillary urothelial carcinoma, was identified. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 1, 2024 Category: Internal Medicine Authors: Burak Tekin, Lori A. Erickson, Sounak Gupta Tags: Path to patient image quiz Source Type: research
Rainbow Trout # 5, Brook Trout # 2, Rockfish # 5, Walley # 5 by Bonnie Murray
Art is integrated into the Mayo Clinic environment. Since the original Mayo Clinic Building was finished in 1914, many pieces have been donated or commissioned for patients and staff to enjoy. Each issue of Mayo Clinic Proceedings features a work of art (as interpreted by the author) that is displayed in a building or on the grounds of Mayo Clinic campuses. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 1, 2024 Category: Internal Medicine Authors: Margaret R. Wentz Tags: Art at mayo clinic Source Type: research
Bringing the Potential Benefits of Omega-3 to a Higher Level
Eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids, the main long-chain omega-3 polyunsaturated fatty acids present in seafood, have been proposed for use in the prevention and treatment of cardiovascular diseases (CVDs). Diet is the primary source of protective fatty acids, but personal preferences and dietary restrictions, among other factors, can prevent people from eating a sufficient amount of food rich in EPA and DHA, so adequate intake of omega-3 fatty acids is not always achieved. Therefore, the use of omega-3 supplements containing EPA and DHA can be recommended to increase EPA and DHA to the appropriate level...
Source: Mayo Clinic Proceedings - April 1, 2024 Category: Internal Medicine Authors: Jari A. Laukkanen, Aldo A. Bernasconi, Carl J. Lavie Tags: Editorial Source Type: research
Is Medical Cannabis a Solution for Controlling Fibromyalgia Symptoms?
Fibromyalgia syndrome (FMS) represents a complex chronic pain disorder primarily characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and cognitive impairment. Because of the complexities it entails, FMS is also manifested with significant challenges in diagnosis and management. Despite numerous approved pharmacologic and nonpharmacologic interventions, the clinical outcomes of patients with FMS remain suboptimal, prompting exploration into new therapeutic modalities. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 1, 2024 Category: Internal Medicine Authors: Paula David, Aia Mohsen, Howard Amital Tags: Editorial Source Type: research
In the Limelight: April 2024
This month ’s feature highlights three articles that appear in the current issue of Mayo Clinic Proceedings. These articles are also featured on the Mayo Clinic Proceedings’ YouTube Channel (https://youtu.be/9emMAR65ZTo). (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 1, 2024 Category: Internal Medicine Authors: Karl A. Nath Tags: In the limelight Source Type: research
Editorial Board
(Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 1, 2024 Category: Internal Medicine Source Type: research
Table of Contents
(Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 1, 2024 Category: Internal Medicine Source Type: research
General Information
(Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 1, 2024 Category: Internal Medicine Source Type: research
Highlights From the Current Issue – Audiovisual Summary
Karl A. Nath, MBChB, Editor-in-Chief of Mayo Clinic Proceedings, discusses the Editor ’s Choice and Highlights articles appearing in the April 2024 issue. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 1, 2024 Category: Internal Medicine Authors: Karl A. Nath Tags: Issue summary Source Type: research
Immunogammopathy Maculopathy
A male in his mid-50s presented with painless and progressive blurred vision on his left eye for several weeks. The patient denied any comorbidities and past ophthalmic history. Best corrected visual acuity was 20/20 on his right eye and 20/40 on the left eye. The right eye examination was unremarkable. The left eye showed vascular and macular alterations (Figure 1). The patient underwent complete multimodal retinal imaging, including a normal indocyanine green angiography. Given this presentation, differentials included retinal, systemic, optic nerve, and inflammatory and neoplastic diseases. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - March 28, 2024 Category: Internal Medicine Authors: Luca Goncalves, Jose Pulido Tags: Medical Image Source Type: research
Metabolic Syndrome and Metabolic Dysfunction-Associated Steatotic Liver Disease in Premenopausal Women
To quantify the burden of metabolic dysfunction –associated steatotic liver disease (MASLD) and related metabolic disorders in premenopausal women. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - March 28, 2024 Category: Internal Medicine Authors: Pojsakorn Danpanichkul, Cheng Han Ng, Mark D. Muthiah, Kwanjit Duangsonk, Siwanart Kongarin, Karan Srisurapanont, Phakkamon Pingwang, Nonlawan Songmueang, Chalida Nonthasoot, Worapaka Manosroi, Surakit Nathisuwan, Fang Li, Ju Dong Yang, Vincent L. Chen, D Tags: Original article Source Type: research
50-Year-Old Man With Fevers, Cough, and Night Sweats
A 50-year-old man presented to the emergency department in August with a 1-month history of progressive nonproductive cough, daily fevers, and drenching night sweats. His medical comorbidities included rheumatoid arthritis. Medications at the time of presentation included adalimumab and occasional acetaminophen as needed. He reported social alcohol use and no tobacco or recreational drug use. He endorsed intermittent headaches, mild dyspnea on exertion, several episodes of feeling off balance, and mild difficulties with short-term memory. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - March 27, 2024 Category: Internal Medicine Authors: Joelle N. Friesen, Alexandra Allman, Omar Abu Saleh Tags: Residents ’ clinic Source Type: research
Laryngeal Amyloidosis
Amyloidosis is a disease characterized by abnormal extracellular deposition of fibrillar proteins in tissues that creates a chronic inflammatory response leading to local tissue injury. The larynx is estimated to be involved in up to 15% of all amyloidosis cases.1 Symptoms of amyloidosis are nonspecific, and the diagnosis is determined by the severity and laryngeal site involved. It typically presents with dysphonia, but patients can also have dyspnea, stridor, odynophagia, cough, and hemoptysis. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - March 27, 2024 Category: Internal Medicine Authors: Renata M. Knoll, Peter M. Sadow, Matthew R. Naunheim Tags: Medical image Source Type: research
