From Womb to Tomb: In Utero Exposure to Tobacco Smoke and Adult Cancers
It is hardly a surprise nowadays to read a new report on tobacco smoking being linked to yet another adult cancer, nor a sense of novelty to hear news on second-hand smoking also a contributor, but it is appalling to learn that in utero exposure to tobacco smoke could lead to deadly cancers decades later. This is exactly the finding published in this issue by He et al.1 Moreover, genetic predisposition measured as cancer polygenic risk score (PRS) was simultaneously analyzed in their study to establish the comparative impact of environment and genes on cancer incidence, demonstrating that high PRS combined with in utero ...
Source: Mayo Clinic Proceedings - August 1, 2023 Category: Internal Medicine Authors: Ping Yang Tags: Editorial Source Type: research
Air Pollution, Physical Activity, and Lifespan
Traditional cardiovascular disease (CVD) risk factors, such as diabetes, hypertension, dyslipidemia, and smoking, have been well recognized in terms of their effect on CVD and all-cause mortality.1 However, nontraditional CVD risk factors, such as inflammatory markers, environmental exposures, and genetic polymorphisms, have only recently begun to be studied extensively.2 (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - August 1, 2023 Category: Internal Medicine Authors: Chayakrit Krittanawong, Yusuf Kamran Qadeer, Carl J. Lavie Tags: Editorial Source Type: research
Age or Functional Debility to Predict Death After Percutaneous Coronary Intervention: Age Is More Than a Number
As the population of the United States ages, the number of older adults with cardiovascular disease is expected to significantly increase.1 Millions of these patients will undergo coronary revascularization for acute or chronic coronary syndromes. Risk stratification in older adults undergoing coronary revascularization is challenging. Prior efforts have largely focused on traditional cardiovascular risk factors and established cardiovascular disease to predict long-term mortality risk.2 Older age is a widely recognized demographic risk factor associated with short- and long-term outcomes after coronary revascularization. ...
Source: Mayo Clinic Proceedings - August 1, 2023 Category: Internal Medicine Authors: Nathaniel R. Smilowitz, Sunil V. Rao Tags: Editorial Source Type: research
Association of Glucosamine Supplementation and Incidence of Heart Failure
It is estimated that 2.6% of the population worldwide is using glucosamine supplements, most commonly for osteoarthritis. Glucosamine, a popular over-the-counter supplement used for osteoarthritis, has been speculated to help with pain relief and to slow degenerative joint disease.1 One in every 4 American adults have some form of osteoarthritis,2 and half of them are aged 65 years or older, which is also the age group with the highest prevalence of cardiovascular disease (CVD).3 (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - August 1, 2023 Category: Internal Medicine Authors: Maria Irene Barillas-Lara, Adrian daSilva-deAbreu, Hector O. Ventura Tags: Editorial Source Type: research
In the Limelight: August 2023
This month ’s feature highlights three articles that appear in the current issue of Mayo Clinic Proceedings. These articles are also featured on the Mayo Clinic Proceedings’ YouTube Channel (https://youtu.be/BPQzVkrjiNA). (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - August 1, 2023 Category: Internal Medicine Authors: Karl A. Nath Tags: In the limelight Source Type: research
Editorial Board
(Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - August 1, 2023 Category: Internal Medicine Source Type: research
Table of Contents
(Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - August 1, 2023 Category: Internal Medicine Source Type: research
General Information
(Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - August 1, 2023 Category: Internal Medicine Source Type: research
Highlights From the Current Issue – Audiovisual Summary
Karl A. Nath, MBChB, Editor-in-Chief of Mayo Clinic Proceedings, discusses the Editor ’s Choice and Highlights articles appearing in the August 2023 issue. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - August 1, 2023 Category: Internal Medicine Authors: Karl A. Nath Source Type: research
Prevalence of and Risk Factors for Post-traumatic Headache in Civilian Patients After Mild Traumatic Brain Injury
To ascertain the prevalence of and risk factors for post-traumatic headache (PTH) attributed to mild traumatic brain injury (mTBI). (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - July 21, 2023 Category: Internal Medicine Authors: H åkan Ashina, David W. Dodick, Jason Barber, Nancy R. Temkin, Catherine D. Chong, Jennifer S. Adler, Ken Shubin Stein, Todd J. Schwedt, Geoffrey T. Manley, TRACK-TBI Investigators Tags: Original Article Source Type: research
59-Year-Old Woman With Fever and Hematemesis
A 59-year-old woman with long-standing seropositive rheumatoid arthritis (RA) presented with cough, fevers, hematemesis, and melena. For the past 2 years, she had experienced intermittent black tarry stools and abdominal pain associated with fatigue and drenching night sweats. However, no source of bleeding was previously found by colonoscopy and esophagogastroduodenoscopy (EGD). In the 3 weeks leading to hospital admission, she began to experience persistent flu-like symptoms with subjective fever, cough productive of greenish-brown sputum, and black stools. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - July 7, 2023 Category: Internal Medicine Authors: Rebecca Yao, Daniela Guerrero Vinsard, Seth Sweetser Tags: Residents ’ Clinic Source Type: research
Subtypes of Type 2 Diabetes and Incident Cardiovascular Disease Risk: UK Biobank and All of Us Cohorts
To characterize and validate the subtypes of type 2 diabetes (T2D) using a novel clustering algorithm and to further assess their associations with the risk of incident cardiovascular disease (CVD) events. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - July 7, 2023 Category: Internal Medicine Authors: Qiaochu Xue, Xiang Li, Xuan Wang, Hao Ma, Yoriko Heianza, Lu Qi Tags: Original Article Source Type: research
81-Year-Old Woman With Symptomatic Bradycardia
An 81-year-old woman presented to the emergency department with several hours of chest tightness and lightheadedness. On evaluation at her skilled nursing facility before transfer, she was found to be bradycardic and hypotensive. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - July 7, 2023 Category: Internal Medicine Authors: Alessandra G. Tomasi, Ryan Alexander, Andrea G. Kattah Tags: Residents ’ Clinic Source Type: research
Questioning the Right to Pain Relief and Its Role in the Opioid Epidemic
The new discipline of palliative care helped to establish the right to pain relief at the end of life and the necessity of using opioids to achieve that goal. Professional pain organizations followed the United Nations ’ model for universal human rights in their declaration of a universal right to pain management. Both palliative care and pain medicine specialties worked to establish pain as a legitimate focus of medical treatment separate from its association with disease. Pain intensity became the metric used to determine the need for treatment and the success of that treatment. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - July 7, 2023 Category: Internal Medicine Authors: Mark D. Sullivan, Jane C. Ballantyne Tags: Special Article Source Type: research
Association Between the Combined Effects of Physical Activity Intensity and Particulate Matter and All-Cause Mortality in Older Adults
To investigate the association between the combined effects of physical activity (PA) intensity and particulate matter ≤10 μm in diameter (PM10) and mortality in older adults. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - July 7, 2023 Category: Internal Medicine Authors: Hanjin Park, Pil-Sung Yang, Jung-Hoon Sung, Moo-Nyun Jin, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung Tags: Original Article Source Type: research
