Integrated mRNA- and miRNA-sequencing analyses unveil the underlying mechanism of tobacco pollutant-induced developmental toxicity in zebrafish embryos
Tobacco pollutants are prevalent in the environment, leading to inadvertent exposure of pregnant females. Studies of these pollutants' toxic effects on embryonic development have not fully elucidated the poten... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 8, 2024 Category: Research Authors: Jiasheng Chen, Yuxin Lin, Deyi Gen, Wanxian Chen, Rui Han, Hao Li, Shijie Tang, Shukai Zheng and Xiaoping Zhong Tags: Research Source Type: research
PTEN deficiency potentiates HBV-associated liver cancer development through augmented GP73/GOLM1
Although hepatitis B virus (HBV) infection is a major risk factor for hepatic cancer, the majority of HBV carriers do not develop this lethal disease. Additional molecular alterations are thus implicated in th... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 8, 2024 Category: Research Authors: Fuqiang Huang, Jing Guo, Na Zhao, Mengjie Hou, Xiaochen Gai, Shuhui Yang, Pei Cai, Yanan Wang, Qian Ma, Qi Zhao, Li Li, Huayu Yang, Yanling Jing, Di Jin, Zhongdong Hu, Xiaojun Zha & hellip; Tags: Research Source Type: research
Impaired balance between neutrophil extracellular trap formation and degradation by DNases in COVID-19 disease
Thrombo-inflammation and neutrophil extracellular traps (NETs) are exacerbated in severe cases of COVID-19, potentially contributing to disease exacerbation. However, the mechanisms underpinning this dysregula... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 7, 2024 Category: Research Authors: Geoffrey Garcia, Sylvie Labrouche-Colomer, Alexandre Duvignaud, Etienne Clequin, Charles Dussiau, David-Alexandre Tr égouët, Denis Malvy, Renaud Prevel, Atika Zouine, Isabelle Pellegrin, Julien Goret, Maria Mamani-Matsuda, Antoine Dewitte and Chloe Jame Tags: Research Source Type: research
Characterization of the proteome of stable and unstable carotid atherosclerotic plaques using data-independent acquisition mass spectrometry
Currently, noninvasive imaging techniques and circulating biomarkers are still insufficient to accurately assess carotid plaque stability, and an in-depth understanding of the molecular mechanisms that contrib... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 7, 2024 Category: Research Authors: Zhichao Lai, Chaonan Wang, Xiaoyan Liu, Haidan Sun, Zhengguang Guo, Jiang Shao, Kang Li, Junye Chen, Jiaxian Wang, Xiangling Lei, Keqiang Shu, Yuyao Feng, Deqiang Kong, Wei Sun and Bao Liu Tags: Research Source Type: research
Inhibition of OGFOD1 by FG4592 confers neuroprotection by activating unfolded protein response and autophagy after ischemic stroke
Acute ischemic stroke is a common neurological disease with a significant financial burden but lacks effective drugs. Hypoxia-inducible factor (HIF) and prolyl hydroxylases (PHDs) participate in the pathophysi... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 7, 2024 Category: Research Authors: Jian Xie, Yuan Zhang, Bin Li, Wen Xi, Yu Wang, Lu Li, Chenchen Liu, Ling Shen, Bing Han, Yan Kong, HongHong Yao and Zhijun Zhang Tags: Research Source Type: research
PLA2G4A and ACHE modulate lipid profiles via glycerophospholipid metabolism in platinum-resistant gastric cancer
Bioactive lipids involved in the progression of various diseases. Nevertheless, there is still a lack of biomarkers and relative regulatory targets. The lipidomic analysis of the samples from platinum-resistan... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 7, 2024 Category: Research Authors: Menglin Chen, Cancan Zhang, Huaizhi Li, Shanshan Zheng, Yaqi Li, Mengyun Yuan, Yuxuan Chen, Jian Wu and Qingmin Sun Tags: Research Source Type: research
Inducing expression of ICOS-L by oncolytic adenovirus to enhance tumor-specific bi-specific antibody efficacy
Intratumoral injection of oncolytic viruses (OVs) shows promise in immunotherapy: ONCOS-102, a genetically engineered OV that encodes Granulocyte –Macrophage Colony-Stimulating Factor (GM-CSF) demonstrated effi... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 7, 2024 Category: Research Authors: Neshat Saffarzadeh, Emelie Foord, Eoghan O ’Leary, Rand Mahmoun, Thomas Birkballe Hansen, Victor Levitsky, Thomas Poiret and Michael Uhlin Tags: Research Source Type: research
Prediction model for EBV infection following HLA haploidentical matched hematopoietic stem cell transplantation
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for hematological malignancies. However, viral infections, particularly EBV infection, frequently occur following allo-H... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 6, 2024 Category: Research Authors: Xun-Hong Cao, Ze-Ying Fan, Ying-Jun Chang, Lan-Ping Xu, Xiao-Hui Zhang, Xiao-Jun Huang and Xiang-Yu Zhao Tags: Research Source Type: research
WNT-inhibitory factor 1-mediated glycolysis protects photoreceptor cells in diabetic retinopathy
In diabetic retinopathy (DR), hypoxia-inducible factor (HIF-1 α) induces oxidative stress by upregulating glycolysis. This process leads to neurodegeneration, particularly photoreceptor cell damage, which furth... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 6, 2024 Category: Research Authors: Bolin Chen, Jing Zou, Lihui Xie, Yinjun Cai, Bowen Li, Wei Tan, Jinhaohao Huang, Fangling Li and Huizhuo Xu Tags: Research Source Type: research
MORN2 regulates the morphology and energy metabolism of mitochondria and is required for male fertility in mice
Mitochondria produce adenosine triphosphate through respiratory activities to power sperm differentiation and motility, and decreased mitochondrial respiratory activity can result in poor sperm motility and as... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 5, 2024 Category: Research Authors: Yining Liu, Tongtong Li, Mingze Shi, Yanling Wan, Hanzhen Li, Mingyu Zhang, Ziqi Wang, Shiyu Wang, Yue Lv, Gang Lu, Hongbin Liu, Haobo Zhang and Tao Huang Tags: Research Source Type: research
Comparing anti-tumor and anti-self immunity in a patient with melanoma receiving immune checkpoint blockade
This study was undertaken to investi... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 5, 2024 Category: Research Authors: Shuming Chen, Tracee L. McMiller, Abha Soni, Farah Succaria, John-William Sidhom, Laura C. Cappelli, Livia A. Casciola-Rosen, Isaac R. Morales, Preethi Sankaran, Alan E. Berger, Julie Stein Deutsch, Qingfeng C. Zhu, Robert A. Anders, Jody E. Hooper, Drew Tags: Research Source Type: research
Sex-related differences in serum biomarker levels predict the activity and efficacy of immune checkpoint inhibitors in advanced melanoma and non-small cell lung cancer patients
Immune Checkpoint Inhibitors (ICIs) lead to durable response and a significant increase in long-term survival in patients with advanced malignant melanoma (MM) and Non-Small Cell Lung Cancer (NSCLC). The ident... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 5, 2024 Category: Research Authors: Giulia Pasello, Aline S. C. Fabricio, Paola Del Bianco, Valentina Salizzato, Adolfo Favaretto, Luisa Piccin, Fable Zustovich, Alessio Fabozzi, Costanza De Rossi, Jacopo Pigozzo, Mattia De Nuzzo, Elia Cappelletto, Laura Bonanno, Dario Palleschi, Gian Luca Tags: Research Source Type: research
Keratinocyte-derived circulating microRNAs in extracellular vesicles: a novel biomarker of psoriasis severity and potential therapeutic target
Psoriasis is a chronic inflammatory disorder characterized by pathogenic hyperproliferation of keratinocytes and immune dysregulation. Currently, objective evaluation tools reflecting the severity of psoriasis... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 4, 2024 Category: Research Authors: Young Joon Park, Dong Chan Kim, Soo-Jin Lee, Han Seul Kim, Ji Young Pak, Junho Kim, Jae Youn Cheong and Eun-So Lee Tags: Research Source Type: research
Development and validation of a machine learning-based predictive model for assessing the 90-day prognostic outcome of patients with spontaneous intracerebral hemorrhage
Spontaneous intracerebral hemorrhage (sICH) is associated with significant mortality and morbidity. Predicting the prognosis of patients with sICH remains an important issue, which significantly affects treatm... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 4, 2024 Category: Research Authors: Zhi Geng, Chaoyi Yang, Ziye Zhao, Yibing Yan, Tao Guo, Chaofan Liu, Aimei Wu, Xingqi Wu, Ling Wei, Yanghua Tian, Panpan Hu and Kai Wang Tags: Research Source Type: research
The interaction between intratumoral bacteria and metabolic distortion in hepatocellular carcinoma
Intratumoral bacteria might play essential roles in tumorigenesis in different cancer types. However, its features and potential roles in hepatocellular carcinoma (HCC) are largely unknown. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 4, 2024 Category: Research Authors: Chen Xue, Xinyu Gu, Qingmiao Shi, Xiao Ma, Junjun Jia, Yuanshuai Su, Zhengyi Bao, Juan Lu and Lanjuan Li Tags: Research Source Type: research
