Inhibition of ferroptosis reverses heart failure with preserved ejection fraction in mice
Heart failure with preserved ejection fraction (HFpEF) accounts for approximately 50% of heart failure cases. The molecular mechanisms by which HFpEF leads to impaired diastolic function of the heart have not ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 24, 2024 Category: Research Authors: Yixiao Xiong, Xin Liu, Ling Jiang, Tao Hao, Yanyan Wang and Tao Li Tags: Research Source Type: research
Acute venous thromboembolism plasma and red blood cell metabolomic profiling reveals potential new early diagnostic biomarkers: observational clinical study
Venous thromboembolism (VTE) is a leading cause of cardiovascular mortality. The diagnosis of acute VTE is based on complex imaging exams due to the lack of biomarkers. Recent multi-omics based research has co... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 24, 2024 Category: Research Authors: Cl áudia Febra, Joana Saraiva, Fátima Vaz, João Macedo, Hamza Mohammad Al-Hroub, Mohammad Harb Semreen, Rui Maio, Vitor Gil, Nelson Soares and Deborah Penque Tags: Research Source Type: research
Cytosolic Cadherin 4 promotes angiogenesis and metastasis in papillary thyroid cancer by suppressing the ubiquitination/degradation of β-catenin
Although the long-term prognosis of papillary thyroid cancer (PTC) is favorable, distant metastasis significantly compromises the prognosis and quality of life for patients with PTC. The Cadherin family plays ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 24, 2024 Category: Research Authors: Luyao Wu, Jian Xiao, Dandan Yi, Haoran Ding, Ru Wang, Zehua Duan, Zhijian Liu, Xianbiao Shi, Meiping Shen and Jianfeng Sang Tags: Research Source Type: research
ACACA reduces lipid accumulation through dual regulation of lipid metabolism and mitochondrial function via AMPK- PPAR α- CPT1A axis
Non-alcoholic fatty liver disease (NAFLD) is a multifaceted metabolic disorder, whose global prevalence is rapidly increasing. Acetyl CoA carboxylases 1 (ACACA) is the key enzyme that controls the rate of fatt... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 23, 2024 Category: Research Authors: Jian Dong, Muzi Li, Runsheng Peng, Yuchuan Zhang, Zilin Qiao and Na Sun Tags: Research Source Type: research
Adaptation of a standardized lifestyle intervention to maximize health outcomes in adolescent metabolic and bariatric surgery patients
Metabolic and bariatric surgery (MBS) is safe and efficacious in treating adolescents with severe obesity. Behavioral/lifestyle programs can support successful preparation for surgery and post-MBS weight loss,... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 23, 2024 Category: Research Authors: Maral Misserian, Alicia Wheelington, Rashon King, Jackson Francis, M. Sunil Mathew, Marlyn A. Allicock, Bethany R. Cartwright, Adejumoke Adewunmi, Aparajita Chandrasekhar, Dhatri Polavarapu, Faisal G. Qureshi, Sarah E. Barlow and Sarah E. Messiah Tags: Methodology Source Type: research
Magnetic resonance imaging-based approaches for detecting the efficacy of combining therapy following VEGFR-2 and PD-1 blockade in a colon cancer model
Angiogenesis inhibitors have been identified to improve the efficacy of immunotherapy in recent studies. However, the delayed therapeutic effect of immunotherapy poses challenges in treatment planning. Therefo... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 23, 2024 Category: Research Authors: Xi Xu, Mengjie Ma, Kunlin Ye, Dong Zhang, Xinhui Chen, Jiayang Wu, Xukai Mo, Zeyu Xiao, Changzheng Shi and Liangping Luo Tags: Research Source Type: research
Ubiquitin-specific protease 14 targets PFKL-mediated glycolysis to promote the proliferation and migration of oral squamous cell carcinoma
In this study, we further demonstrated that aberrantl... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 22, 2024 Category: Research Authors: Xingming Zhang, Lou Geng, Yi Tang, Yingying Wang, Youping Zhang, Chujiao Zhu, Hu Lei, Hanzhang Xu, Qi Zhu, Yingli Wu and Wenli Gu Tags: Research Source Type: research
From pixels to patient care: deep learning-enabled pathomics signature offers precise outcome predictions for immunotherapy in esophageal squamous cell cancer
This study aimed to perform a... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 22, 2024 Category: Research Authors: Butuo Li, Wenru Qin, Linlin Yang, Haoqian Li, Chao Jiang, Yueyuan Yao, Shuping Cheng, Bing Zou, Bingjie Fan, Taotao Dong and Linlin Wang Tags: Research Source Type: research
A proteomic classifier panel for early screening of colorectal cancer: a case control study
Diagnosis of colorectal cancer (CRC) during early stages can greatly improve patient outcome. Although technical advances in the field of genomics and proteomics have identified a number of candidate biomarker... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 21, 2024 Category: Research Authors: Hanju Hua, Tingting Wang, Liangxuan Pan, Xiaoyao Du, Tianxue Xia, Zhenzhong Fa, Lei Gu, Fei Gao, Chaohui Yu, Feng Gao, Lujian Liao and Zhe Shen Tags: Research Source Type: research
A community challenge to predict clinical outcomes after immune checkpoint blockade in non-small cell lung cancer
Predictive biomarkers of immune checkpoint inhibitor (ICI) efficacy are currently lacking for non-small cell lung cancer (NSCLC). Here, we describe the results from the Anti –PD-1 Response Prediction DREAM Chal... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 21, 2024 Category: Research Authors: Mike Mason, Óscar Lapuente-Santana, Anni S. Halkola, Wenyu Wang, Raghvendra Mall, Xu Xiao, Jacob Kaufman, Jingxin Fu, Jacob Pfeil, Jineta Banerjee, Verena Chung, Han Chang, Scott D. Chasalow, Hung Ying Lin, Rongrong Chai, Thomas Yu & hellip; Tags: Research Source Type: research
Fatigue and symptom-based clusters in post COVID-19 patients: a multicentre, prospective, observational cohort study
This study aimed to determine the occurrence of fatigue and other symptoms, to ass... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 21, 2024 Category: Research Authors: Merel E. B. Cornelissen, Lizan D. Bloemsma, Anouk W. Vaes, Nadia Baalbaki, Qichen Deng, Rosanne J. H. C. G. Beijers, Lieke C. E. Noij, Laura Houweling, Somayeh Bazdar, Martijn A. Spruit and Anke H. Maitland-van der Zee Tags: Research Source Type: research
ZSWIM4 inhibition improves chemosensitivity in epithelial ovarian cancer cells by suppressing intracellular glycine biosynthesis
In this study, we aimed to investigate the clin... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 21, 2024 Category: Research Authors: Kunxiang Gong, Yinger Huang, Yanqin Zheng, Wenbo Hao and Kun Shi Tags: Research Source Type: research
Multi-modal assessment of a cardiac stem cell therapy reveals distinct modulation of regional scar properties
The initial idea of functional tissue replacement has shifted to the concept that injected cells positively modulate myocardial healing by a non-specific immune response of the transplanted cells within the ta... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 21, 2024 Category: Research Authors: Moritz Schweins, Ralf G äbel, Matti Raitza, Praveen Vasudevan, Heiko Lemcke, Markus Joksch, Anna Schildt, Jens Kurth, Tobias Lindner, Felix G. Meinel, Alper Öner, Hüseyin Ince, Brigitte Vollmar, Bernd Joachim Krause, Robert David and Cajetan Immanuel L Tags: Research Source Type: research
An angel or a devil? Current view on the role of CD8+ T cells in the pathogenesis of myasthenia gravis
Myasthenia gravis (MG) and the experimental autoimmune MG (EAMG) animal model are characterized by T-cell-induced and B-cell-dominated autoimmune diseases that affect the neuromuscular junction. Several subtyp... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 20, 2024 Category: Research Authors: Yong Peng, Huan Yang, Quan Chen, Hong Jin, Ya-hui Xue, Miao-qiao Du, Shu Liu and Shun-yu Yao Tags: Review Source Type: research
High somatic mutations in circulating tumor DNA predict response of metastatic pancreatic ductal adenocarcinoma to first-line nab-paclitaxel plus S-1: prospective study
We previously showed that the nab-paclitaxel plus S-1 (NPS) regimen had promising effects against metastatic pancreatic ducal adenocarcinoma (mPDAC), whose efficacy however could not be precisely predicted by ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 20, 2024 Category: Research Authors: Lei Huang, Yao Lv, Shasha Guan, Huan Yan, Lu Han, Zhikuan Wang, Quanli Han, Guanghai Dai and Yan Shi Tags: Research Source Type: research
