CD19/CD20 dual-targeted chimeric antigen receptor-engineered natural killer cells exhibit improved cytotoxicity against acute lymphoblastic leukemia
Chimeric antigen receptor natural killer (CAR-NK) cells represent a promising advancement in CAR cell therapy, addressing limitations observed in CAR-T cell therapy. However, our prior study revealed challenge... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 13, 2024 Category: Research Authors: Na Yang, Caili Zhang, Yingchun Zhang, Yuting Fan, Jing Zhang, Xiaojin Lin, Ting Guo, Yangzuo Gu, Jieheng Wu, Jianmei Gao, Xing Zhao and Zhixu He Tags: Research Source Type: research
Impact of myelofibrosis on patients with myelodysplastic syndromes following allogeneic hematopoietic stem cell transplantation
The prognostic significance of myelofibrosis (MF) grade in patients with myelodysplastic syndrome (MDS) following an allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains elusive. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 13, 2024 Category: Research Authors: Panpan Zhu, Xiaoyu Lai, Lizhen Liu, Jimin Shi, Jian Yu, Yanmin Zhao, Luxin Yang, Tingting Yang, Weiyan Zheng, Jie Sun, Wenjun Wu, Yi Zhao, Zhen Cai, He Huang and Yi Luo Tags: Research Source Type: research
Bacterial DnaK reduces the activity of anti-cancer drugs cisplatin and 5FU
Chemotherapy is a primary treatment for cancer, but its efficacy is often limited by cancer-associated bacteria (CAB) that impair tumor suppressor functions. Our previous research found that Mycoplasma fermentans (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 12, 2024 Category: Research Authors: Francesca Benedetti, Emmanuel F. Mongodin, Jonathan H. Badger, Arshi Munawwar, Ashley Cellini, Weirong Yuan, Giovannino Silvestri, Carl N. Kraus, Simone Marini, Chozha V. Rathinam, Marco Salemi, Herv é Tettelin, Robert C. Gallo and Davide Zella Tags: Research Source Type: research
HBV DNA polymerase upregulates the transcription of PD-L1 and suppresses T cell activity in hepatocellular carcinoma
In HBV-associated HCC, T cells often exhibit a state of functional exhaustion, which prevents the immune response from rejecting the tumor and allows HCC to progress. Moreover, polymerase-specific T cells exhi... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 12, 2024 Category: Research Authors: Yan Jia, Jianing Zhao, Chunqing Wang, Jing Meng, Liqing Zhao, Hongwei Yang and Xiaoqing Zhao Tags: Research Source Type: research
CAR T cells and T cells phenotype and function are impacted by glucocorticoid exposure with different magnitude
Chimeric antigen receptor (CAR) T cell therapy is associated with high risk of adverse events. Glucocorticoids (GCs) are cornerstone in the management of high-grade cytokine release syndrome (CRS) and immune e... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 12, 2024 Category: Research Authors: Thomas Poiret, Sara Vikberg, Esther Schoutrop, Jonas Mattsson and Isabelle Magalhaes Tags: Research Source Type: research
Kynurenine in IDO1high cancer cell-derived extracellular vesicles promotes angiogenesis by inducing endothelial mitophagy in ovarian cancer
Mitophagy, a prominent cellular homeostasis process, has been implicated in modulating endothelial cell function. Emerging evidence suggests that extracellular vesicles (EVs) participate in intercellular commu... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 11, 2024 Category: Research Authors: Xiang Ying, Xiaocui Zheng, Xiaoqian Zhang, Yujia Yin and Xipeng Wang Tags: Research Source Type: research
Predicting long-term progression of Alzheimer ’s disease using a multimodal deep learning model incorporating interaction effects
Identifying individuals with mild cognitive impairment (MCI) at risk of progressing to Alzheimer ’s disease (AD) provides a unique opportunity for early interventions. Therefore, accurate and long-term predicti... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 11, 2024 Category: Research Authors: Yifan Wang, Ruitian Gao, Ting Wei, Luke Johnston, Xin Yuan, Yue Zhang and Zhangsheng Yu Tags: Research Source Type: research
Routine evaluation of HBV-specific T cell reactivity in chronic hepatitis B using a broad-spectrum T-cell epitope peptide library and ELISpot assay
The clinical routine test of HBV-specific T cell reactivity is still limited due to the high polymorphisms of human leukocyte antigens (HLA) in patient cohort and the lack of universal detection kit, thus the ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 11, 2024 Category: Research Authors: Yandan Wu, Xiaotao Liu, Yuan Mao, Ruixue Ji, Lingzhi Xia, Zining Zhou, Yan Ding, Pinqing Li, Yu Zhao, Min Peng, Jie Qiu and Chuanlai Shen Tags: Research Source Type: research
Proteomic analysis of mitochondria associated membranes in renal ischemic reperfusion injury
The mitochondria and endoplasmic reticulum (ER) communicate via contact sites known as mitochondria associated membranes (MAMs). Many important cellular functions such as bioenergetics, mitophagy, apoptosis, a... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 10, 2024 Category: Research Authors: Yi Li, Hua-bin Wang, Jin-long Cao, Wen-jun Zhang, Hai-long Wang, Chang-hong Xu, Kun-peng Li, Yi Liu, Ji-rong Wang, Hua-lan Ha, Sheng-jun Fu and Li Yang Tags: Research Source Type: research
A strategy to pioneer key agent(s) in Cephalotaxus alkaloids against pan-cancer via filtering methodology based on integrated pharmacology
(Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 10, 2024 Category: Research Authors: Ki-Kwang Oh, Sang-Jun Yoon, Jung-A Eom, Kyeong Jin Lee, Goo-Hyun Kwon, Dong Joon Kim and Ki-Tae Suk Tags: Letter to the Editor Source Type: research
Exosomal circRNAs in the plasma serve as novel biomarkers for IPF diagnosis and progression prediction
Idiopathic Pulmonary Fibrosis (IPF) is a type of chronic interstitial pneumonia, often fatal, with elusive causes and a bleak prognosis. Its treatment options are limited and largely ineffective. Early detecti... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 10, 2024 Category: Research Authors: Wenhua Gan, Wenwen Song, Yujuan Gao, Xuexue Zheng, Fengjuan Wang, Zirui Zhang, Ke Zen, Hongwei Liang and Xin Yan Tags: Research Source Type: research
Identification and functional activity of Nik related kinase (NRK) in benign hyperplastic prostate
Benign prostatic hyperplasia (BPH) is common in elder men. The current study aims to identify differentially expressed genes (DEGs) in hyperplastic prostate and to explore the role of Nik related kinase (NRK) ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 9, 2024 Category: Research Authors: Weixiang He, Zelin Tian, Bingchen Dong, Yitong Cao, Wei Hu, Peng Wu, Lei Yu, Xinhua Zhang and Shanshan Guo Tags: Research Source Type: research
CircGLIS3 promotes gastric cancer progression by regulating the miR-1343-3p/PGK1 pathway and inhibiting vimentin phosphorylation
Circular RNAs (circRNAs) have been proved to play crucial roles in the development of various cancers. However, the molecular mechanism of circGLIS3 involved in gastric cancer (GC) tumorigenesis has not been e... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 8, 2024 Category: Research Authors: Yongxin Zhang, Xiaofeng Wang, Wenwei Liu, Tianxiang Lei, Tang Qiao, Wei Feng and Wu Song Tags: Research Source Type: research
Association of domain-specific physical activity with albuminuria among prediabetes and diabetes: a large cross-sectional study
Albuminuria, the presence of excess of protein in urine, is a well-known risk factor for early kidney damage among diabetic/prediabetic patients. There is a complex interaction between physical activity (PA) a... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 8, 2024 Category: Research Authors: Bingquan Xiong, Yufan Wang, Juan He, Lisha Wang, Rui He, Min Zhu, Jiaxing Wang, Yingrui Li, Bin Liu, Kaihu Xiao and Qiang She Tags: Research Source Type: research
Integrated mRNA- and miRNA-sequencing analyses unveil the underlying mechanism of tobacco pollutant-induced developmental toxicity in zebrafish embryos
Tobacco pollutants are prevalent in the environment, leading to inadvertent exposure of pregnant females. Studies of these pollutants' toxic effects on embryonic development have not fully elucidated the poten... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 8, 2024 Category: Research Authors: Jiasheng Chen, Yuxin Lin, Deyi Gen, Wanxian Chen, Rui Han, Hao Li, Shijie Tang, Shukai Zheng and Xiaoping Zhong Tags: Research Source Type: research
