New advances of the androgen receptor in prostate cancer: report from the 1st International Androgen Receptor Symposium
The androgen receptor (AR) is a crucial player in various aspects of male reproduction and has been associated with the development and progression of prostate cancer (PCa). Therefore, the protein is the linch... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 18, 2024 Category: Research Authors: Sherif Mehralivand, Christian Thomas, Martin Puhr, Frank Claessens, Arjanneke F. van de Merbel, Anna Dubrovska, Guido Jenster, Christof Bernemann, Ulrich Sommer and Holger H. H. Erb Tags: Meeting report Source Type: research
Unraveling the underlying pathogenic factors driving nonalcoholic steatohepatitis and hepatocellular carcinoma: an in-depth analysis of prognostically relevant gene signatures in hepatocellular carcinoma
Nonalcoholic steatohepatitis (NASH) is a progressive manifestation of nonalcoholic fatty liver disease (NAFLD) that can lead to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Despite the growing know... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 18, 2024 Category: Research Authors: Yuan Ni, Maoqing Lu, Ming Li, Xixi Hu, Feng Li, Yan Wang and Dong Xue Tags: Research Source Type: research
MTFR2-dependent mitochondrial fission promotes HCC progression
The role of mitochondrial dynamics, encompassing fission, fusion, and mitophagy, in cancer progression has been extensively studied. However, the specific impact of mitochondrial dynamics on hepatocellular car... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 18, 2024 Category: Research Authors: La Zhang, Xiuzhen Zhang, Haichuan Liu, Changhong Yang, Jiyao Yu, Wei Zhao, Jiao Guo, Baoyong Zhou and Ning Jiang Tags: Research Source Type: research
Pharmacological and cell-based treatments to increase local skin flap viability in animal models
Local skin flaps are frequently employed for wound closure to address surgical, traumatic, congenital, or oncologic defects. (1) Despite their clinical utility, skin flaps may fail due to inadequate perfusion,... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 17, 2024 Category: Research Authors: Charlotte E. Berry, Thalia Le, Nicholas An, Michelle Griffin, Micheal Januszyk, Carter B. Kendig, Alexander Z. Fazilat, Andrew A. Churukian, Phoebe M. Pan and Derrick C. Wan Tags: Review Source Type: research
Vein wall thickness and severity of pulmonary involvement due to sars n-cov2 virus infection
An observational study involving patients recovered from COVID-19 was conducted in order to evaluate the presence/absence of vein wall thickness increasing, according to the severity of pulmonary involvement q... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 17, 2024 Category: Research Authors: Gennaro Quarto, Giacomo Benassai, Annamaria Colao, Antonio Cittadini, Paolo Antonio Ascierto, Rosario Pivonello, Andrea Elefante, Marialuisa Bocchino, Alberto Maria Marra, Ivan Gentile, Gianluca Benassai, Andrea Miletti, Francesca Calemma and Ermenegildo Tags: Research Source Type: research
Tumor-associated macrophages in colorectal cancer metastasis: molecular insights and translational perspectives
Metastasis is the leading cause of high mortality in colorectal cancer (CRC), which is not only driven by changes occurring within the tumor cells, but is also influenced by the dynamic interaction between can... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 16, 2024 Category: Research Authors: Siyu Hou, Yuanchun Zhao, Jiajia Chen, Yuxin Lin and Xin Qi Tags: Review Source Type: research
Intracellular delivery of Parkin-RING0-based fragments corrects Parkin-induced mitochondrial dysfunction through interaction with SLP-2
Loss-of-function mutations in the PRKN gene, encoding Parkin, are the most common cause of autosomal recessive Parkinson ’s disease (PD). We have previously identified mitoch (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 16, 2024 Category: Research Authors: Alessandra Zanon, Marianna Guida, Alexandros A. Lavdas, Corrado Corti, Maria Paulina Castelo Rueda, Alessandro Negro, Peter P. Pramstaller, Francisco S. Domingues, Andrew A. Hicks and Irene Pichler Tags: Research Source Type: research
Gastroesophageal reflux disease and the risk of respiratory diseases: a Mendelian randomization study
Observational studies have suggested a suspected association between gastroesophageal reflux disease (GERD) and respiratory diseases, but the causality remains equivocal. The goal of this study was to evaluate... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 16, 2024 Category: Research Authors: Rui Dong, Qianqian Zhang and Hongxing Peng Tags: Research Source Type: research
Inhibition of soluble epoxide hydrolase enhances the dentin-pulp complex regeneration mediated by crosstalk between vascular endothelial cells and dental pulp stem cells
Revascularization and restoration of normal pulp-dentin complex are important for tissue-engineered pulp regeneration. Recently, a unique periodontal tip-like endothelial cells subtype (POTCs) specialized to d... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 16, 2024 Category: Research Authors: Lingwenyao Kong, Juanjuan Li, Yuwen Bai, Shaoyang Xu, Lin Zhang, Weixian Chen, Lu Gao and Fu Wang Tags: Research Source Type: research
Integrating single-cell and bulk RNA sequencing data unveils antigen presentation and process-related CAFS and establishes a predictive signature in prostate cancer
Cancer-associated fibroblasts (CAFs) are heterogeneous and can influence the progression of prostate cancer in multiple ways; however, their capacity to present and process antigens in PRAD has not been invest... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 14, 2024 Category: Research Authors: Wenhao Wang, Tiewen Li, Zhiwen Xie, Jing Zhao, Yu Zhang, Yuan Ruan and Bangmin Han Tags: Research Source Type: research
Melatonin as an immunomodulator in CD19-targeting CAR-T cell therapy: managing cytokine release syndrome
Chimeric antigen receptor CAR-T cell therapies have ushered in a new era of treatment for specific blood cancers, offering unparalleled efficacy in cases of treatment resistance or relapse. However, the emerge... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 14, 2024 Category: Research Authors: Na Zheng, Yihao Long, Zixuan Bai, Jianing Li, Hongyu Wang, Dan-Dan Song, Hong-Lin Liu, Jian-Hong Shi and Shuli Zhao Tags: Research Source Type: research
Metabolic reprogramming based on RNA sequencing of gemcitabine-resistant cells reveals the FASN gene as a therapeutic for bladder cancer
Bladder cancer (BLCA) is the most frequent malignant tumor of the genitourinary system. Postoperative chemotherapy drug perfusion and chemotherapy are important means for the treatment of BLCA. However, once d... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 13, 2024 Category: Research Authors: Lijie Zhou, Kaixuan Du, Yiheng Dai, Youmiao Zeng, Yongbo Luo, Mengda Ren, Wenbang Pan, Yuanhao Liu, Lailai Zhang, Ronghui Zhu, Dapeng Feng, Fengyan Tian and Chaohui Gu Tags: Research Source Type: research
Whole-orbit radiomics: machine learning-based multi- and fused- region radiomics signatures for intravenous glucocorticoid response prediction in thyroid eye disease
Radiomics analysis of orbital magnetic resonance imaging (MRI) shows preliminary potential for intravenous glucocorticoid (IVGC) response prediction of thyroid eye disease (TED). The current region of interest... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 13, 2024 Category: Research Authors: Haiyang Zhang, Mengda Jiang, Hoi Chi Chan, Huijie Zhang, Jiashuo Xu, Yuting Liu, Ling Zhu, Xiaofeng Tao, Duojin Xia, Lei Zhou, Yinwei Li, Jing Sun, Xuefei Song, Huifang Zhou and Xianqun Fan Tags: Research Source Type: research
Brain-targeted delivery of neuroprotective survival gene minimizing hematopoietic cell contamination: implications for Parkinson ’s disease treatment
Neurodegenerative diseases, including Parkinson's disease, Amyotropic Lateral Sclerosis (ALS) and Alzheimer's disease, present significant challenges for therapeutic development due to drug delivery restrictio... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 13, 2024 Category: Research Authors: Min Hak Lee, Sukyeong Kang, Ki-Hwan Um, Seok Won Lee, Hyorin Hwang, Kyunghwa Baek and Jin Woo Choi Tags: Research Source Type: research
MicroRNA-93-5p regulates odontogenic differentiation and dentin formation via KDM6B
Epigenetic factors influence the odontogenic differentiation of dental pulp stem cells and play indispensable roles during tooth development. Some microRNAs can epigenetically regulate other epigenetic factors... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 13, 2024 Category: Research Authors: Si Wu, Xin Xu, Shiqi Gao, Sibei Huo, Mian Wan, Xin Zhou, Xuedong Zhou, Liwei Zheng and Yachuan Zhou Tags: Research Source Type: research
