MicroRNA-21a-5p inhibition alleviates systemic sclerosis by targeting STAT3 signaling
MicroRNA (miRNA)-21-5p participates in various biological processes, including cancer and autoimmune diseases. However, its role in the development of fibrosis in the in vivo model of systemic sclerosis (SSc) ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 1, 2024 Category: Research Authors: Jin-Sil Park, Chongtae Kim, JeongWon Choi, Ha Yeon Jeong, Young-Mee Moon, Hoin Kang, Eun Kyung Lee, Mi-La Cho and Sung-Hwan Park Tags: Research Source Type: research
Very low-calorie ketogenic diet (VLCKD): a therapeutic nutritional tool for acne?
Acne, a chronic inflammatory disease impacting the pilosebaceous unit, is influenced significantly by inflammation and oxidative stress, and is commonly associated with obesity. Similarly, obesity is also asso... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 31, 2024 Category: Research Authors: Ludovica Verde, Evelyn Frias-Toral, Sara Cacciapuoti, Daniel Simancas-Racines, Matteo Megna, Giuseppina Caiazzo, Luca Potestio, Maria Maisto, Gian Carlo Tenore, Annamaria Colao, Silvia Savastano, Giovanna Muscogiuri and Luigi Barrea Tags: Research Source Type: research
Focused ultrasound-mediated blood –brain barrier opening is safe and feasible with moderately hypofractionated radiotherapy for brainstem diffuse midline glioma
Diffuse midline glioma (DMG) is a pediatric tumor with dismal prognosis. Systemic strategies have been unsuccessful and radiotherapy (RT) remains the standard-of-care. A central impediment to treatment is the ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 30, 2024 Category: Research Authors: Masih Tazhibi, Nicholas McQuillan, Hong-Jian Wei, Matthew Gallitto, Ethan Bendau, Andrea Webster Carrion, Xander Berg, Danae Kokossis, Xu Zhang, Zhiguo Zhang, Chia-Ing Jan, Akiva Mintz, Robyn D. Gartrell, Hasan R. Syed, Adriana Fonseca, Jovana Pavisic & h Tags: Research Source Type: research
An integrated framework for prognosis prediction and drug response modeling in colorectal liver metastasis drug discovery
Colorectal cancer (CRC) is the third most prevalent cancer globally, and liver metastasis (CRLM) is the primary cause of death. Hence, it is essential to discover novel prognostic biomarkers and therapeutic dr... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 30, 2024 Category: Research Authors: Xiuman Zhou, Yuzhen Qian, Chen Ling, Zhuoying He, Peishang Shi, Yanfeng Gao and Xinghua Sui Tags: Research Source Type: research
Enhanced predictive validity of integrative models for refractory hyperthyroidism considering baseline and early therapy characteristics: a prospective cohort study
A subset of Graves ’ disease (GD) patients develops refractory hyperthyroidism, posing challenges in treatment decisions. The predictive value of baseline characteristics and early therapy indicators in identif... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 29, 2024 Category: Research Authors: Xinpan Wang, Tiantian Li, Yue Li, Qiuyi Wang, Yun Cai, Zhixiao Wang, Yun Shi, Tao Yang and Xuqin Zheng Tags: Research Source Type: research
Language and cultural bias in AI: comparing the performance of large language models developed in different countries on Traditional Chinese Medicine highlights the need for localized models
(Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 29, 2024 Category: Research Authors: Lingxuan Zhu, Weiming Mou, Yancheng Lai, Junda Lin and Peng Luo Tags: Letter to the Editor Source Type: research
Propofol improves survival in a murine model of sepsis via inhibiting Rab5a-mediated intracellular trafficking of TLR4
Propofol is a widely used anesthetic and sedative, which has been reported to exert an anti-inflammatory effect. TLR4 plays a critical role in coordinating the immuno-inflammatory response during sepsis. Wheth... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 28, 2024 Category: Research Authors: Bo-Wei Zhou, Wen-Juan Zhang, Fang-Ling Zhang, Xiao Yang, Yu-Qi Ding, Zhi-Wen Yao, Zheng-Zheng Yan, Bing-Cheng Zhao, Xiao-Dong Chen, Cai Li and Ke-Xuan Liu Tags: Research Source Type: research
Getting more bang for their buck: BCL2 inhibitors boost dendritic-cell function to enhance anti-cancer immune surveillance
The anti-apoptotic BCL-2 protein family regulates cancer cell survival, thus it represents an important therapeutic target. Indeed, a drug class, called BH3-mimetics, have been developed to directly target BCL... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 28, 2024 Category: Research Authors: Alfredo E. Montes-G ómez and Stephen W. G. Tait Tags: Commentary Source Type: research
Characterizing and forecasting neoantigens-resulting from MUC mutations in COAD
The treatment for colon adenocarcinoma (COAD) faces challenges in terms of immunotherapy effectiveness due to multiple factors. Because of the high tumor specificity and immunogenicity, neoantigen has been con... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 27, 2024 Category: Research Authors: Min Chen, Xin Zhang, Zihe Ming, Lingyu, Xiaorong Feng, Zhenguo Han and Han-Xiang An Tags: Research Source Type: research
Dihydromyricetin ameliorates hepatic steatosis and insulin resistance via AMPK/PGC-1 α and PPARα-mediated autophagy pathway
Dihydromyricetin (DHM), a flavonoid compound of natural origin, has been identified in high concentrations in ampelopsis grossedentata and has a broad spectrum of biological and pharmacological functions, particu... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 26, 2024 Category: Research Authors: Yan Yang, Wen Qiu, Jiyuan Xiao, Jie Sun, Xuan Ren and Luxia Jiang Tags: Research Source Type: research
Exosomes from senescent epithelial cells activate pulmonary fibroblasts via the miR-217-5p/Sirt1 axis in paraquat-induced pulmonary fibrosis
Paraquat (PQ) is a widely used and highly toxic herbicide that poses a significant risk to human health. The main consequence of PQ poisoning is pulmonary fibrosis, which can result in respiratory failure and ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 26, 2024 Category: Research Authors: Min Zhang, Xiang Xue, Zhenshuai Lou, Yanhong Lin, Qian Li and Changbao Huang Tags: Research Source Type: research
Identifying flaws in the GWAS datasets of a published Mendelian randomization study: complementary re-evaluation and suggestion for analytical refinements
(Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 26, 2024 Category: Research Authors: Jia-Cheng Xiang, Yi-Fan Xiong, Shao-Gang Wang and Qi-Dong Xia Tags: Letter to the Editor Source Type: research
Recent advances in endothelial colony-forming cells: from the transcriptomic perspective
Endothelial colony-forming cells (ECFCs) are progenitors of endothelial cells with significant proliferative and angiogenic ability. ECFCs are a promising treatment option for various diseases, such as ischemi... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 26, 2024 Category: Research Authors: Yaqiong Liu, Caomh án J. Lyons, Christine Ayu and Timothy O’Brien Tags: Review Source Type: research
Identification of novel protein biomarkers from the blood and urine for the early diagnosis of bladder cancer via proximity extension analysis
In this study, we identified BC biomarkers and described a new noninvasive detection method using serum an... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 26, 2024 Category: Research Authors: Tong Kong, Yang Qu, Taowa Zhao, Zitong Niu, Xiuyi Lv, Yiting Wang, Qiaojiao Ding, Pengyao Wei, Jun Fu, Liang Wang, Jing Gao, Cheng Zhou, Suying Wang, Junhui Jiang, Jianping Zheng, Kaizhe Wang & hellip; Tags: Research Source Type: research
Integrative multi-omics analysis identifies genetically supported druggable targets and immune cell specificity for myasthenia gravis
Myasthenia gravis (MG) is a chronic autoimmune disorder characterized by fluctuating muscle weakness. Despite the availability of established therapies, the management of MG symptoms remains suboptimal, partia... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 24, 2024 Category: Research Authors: Jiao Li, Fei Wang, Zhen Li, Jingjing Feng, Yi Men, Jinming Han, Jiangwei Xia, Chen Zhang, Yilai Han, Teng Chen, Yinan Zhao, Sirui Zhou, Yuwei Da, Guoliang Chai and Junwei Hao Tags: Research Source Type: research
