Multi-institutional prognostic modeling of survival outcomes in NSCLC patients treated with first-line immunotherapy using radiomics
Immune checkpoint inhibitors (ICIs) have emerged as one of the most promising first-line therapeutics in the management of non-small cell lung cancer (NSCLC). However, only a subset of these patients responds ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 10, 2024 Category: Research Authors: Sevinj Yolchuyeva, Leyla Ebrahimpour, Marion Tonneau, Fabien Lamaze, Michele Orain, Fran çois Coulombe, Julie Malo, Wiam Belkaid, Bertrand Routy, Philippe Joubert and Venkata SK. Manem Tags: Research Source Type: research
Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis
Hepatocellular carcinoma (HCC) remains a leading life-threatening health challenge worldwide, with pressing needs for novel therapeutic strategies. Sphingosine kinase 1 (SphK1), a well-established pro-cancer e... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 10, 2024 Category: Research Authors: Xin Tracy Liu, Yu Huang, Da Liu, Yingxin Celia Jiang, Min Zhao, Long Hoa Chung, Xingxing Daisy Han, Yinan Zhao, Jinbiao Chen, Paul Coleman, Ka Ka Ting, Collin Tran, Yingying Su, Claude Vincent Dennis, Atul Bhatnagar, Ken Liu & hellip; Tags: Research Source Type: research
Sex-differences in Mediterranean diet: a key piece to explain sex-related cardiovascular risk in obesity? A cross-sectional study
Mediterranean Diet (MD) has many health benefits, particularly in reducing cardiovascular risk (CVR). However, it is still little known if there are any sex differences in following this nutritional pattern an... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 10, 2024 Category: Research Authors: Luigi Barrea, Ludovica Verde, Rosario Su árez, Evelyn Frias-Toral, Celina Andrade Vásquez, Annamaria Colao, Silvia Savastano and Giovanna Muscogiuri Tags: Research Source Type: research
DEL-1: a promising treatment for AMD-associated ER stress in retinal pigment epithelial cells
Age-related macular degeneration (AMD) is an irreversible eye disease that can cause blurred vision. Regular exercise has been suggested as a therapeutic strategy for treating AMD, but how exercise improves AM... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 9, 2024 Category: Research Authors: ChangHyuk Kwon, Wonjun Cho, Sung Woo Choi, Heeseung Oh, A. M. Abd El-Aty, Ibrahim Gecili, Ji Hoon Jeong and Tae Woo Jung Tags: Research Source Type: research
Expression of HLA-DR by mesenchymal stromal cells in the platelet lysate era: an obsolete release criterion for MSCs?
According to the definition of the International Society for Cell and Gene Therapy (ISCT), mesenchymal stromal cells (MSCs) do not express HLA-DR. This phenotypic marker as a release criterion for clinical use... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 9, 2024 Category: Research Authors: Zyrafete Ku çi, Natascha Piede, Kathrin Vogelsang, Lisa-Marie Pfeffermann, Sibylle Wehner, Emilia Salzmann-Manrique, Miriam Stais, Hermann Kreyenberg, Halvard Bonig, Peter Bader and Selim Kuçi Tags: Research Source Type: research
Dietary sulfur amino acid restriction in humans with overweight and obesity: a translational randomized controlled trial
In this study, we investigated the effect of dietary SAAR on body weight, body composition, resting metabolic rate, gene expre... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 9, 2024 Category: Research Authors: Thomas Olsen, Emma Stolt, Bente Øvrebø, Amany Elshorbagy, Elena C. Tore, Sindre Lee-Ødegård, Hannibal Troensegaard, Hanna Johannessen, Beate Doeland, Anna A. D. Vo, Anja F. Dahl, Karianne Svendsen, Magne Thoresen, Helga Refsum, Russell Rising, Kristý Tags: Research Source Type: research
Central 5-HTergic hyperactivity induces myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)-like pathophysiology
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a significant medical challenge, with no indisputable pathophysiological mechanism identified to date. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 8, 2024 Category: Research Authors: Jin-Seok Lee, Ji-Yun Kang, Samuel-Young Park, Seung-Ju Hwang, Sung-Jin Bae and Chang-Gue Son Tags: Research Source Type: research
Novel cellular systems unveil mucosal melanoma initiating cells and a role for PI3K/Akt/mTOR pathway in mucosal melanoma fitness
Mucosal Melanomas (MM) are highly aggressive neoplasms arising from mucosal melanocytes. Current treatments offer a limited survival benefit for patients with advanced MM; moreover, the lack of pre-clinical ce... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 8, 2024 Category: Research Authors: Matilde Monti, Luisa Benerini Gatta, Mattia Bugatti, Irene Pezzali, Sara Picinoli, Marcello Manfredi, Antonio Lavazza, Virginia Vita Vanella, Veronica De Giorgis, Lucia Zanatta, Francesco Missale, Silvia Lonardi, Benedetta Zanetti, Giovanni Bozzoni, Moris Tags: Research Source Type: research
Correction: Epithelial cell adhesion molecule (EpCAM) regulates HGFR signaling to promote colon cancer progression and metastasis
(Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 8, 2024 Category: Research Authors: Chi-Chiu Lee, Chia-Jui Yu, Sushree Shankar Panda, Kai-Chi Chen, Kang-Hao Liang, Wan-Chen Huang, Yu-Shiuan Wang, Pei-Chin Ho and Han-Chung Wu Tags: Correction Source Type: research
Single-cell transcriptome sequencing reveals aberrantly activated inter-tumor cell signaling pathways in the development of clear cell renal cell carcinoma
Aberrant intracellular or intercellular signaling pathways are important mechanisms that contribute to the development and progression of cancer. However, the intercellular communication associated with the de... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 8, 2024 Category: Research Authors: Junfeng Zhang, Fuzhong Liu, Wenjia Guo, Xing Bi, Shuai Yuan, Fuerhaiti Shayiti, Ting Pan, Kailing Li and Peng Chen Tags: Research Source Type: research
The spike-specific TCR β repertoire shows distinct features in unvaccinated or vaccinated patients with SARS-CoV-2 infection
The evolving variants of SARS-CoV-2 may escape immunity from prior infections or vaccinations. It ’s vital to understand how immunity adapts to these changes. Both infection and mRNA vaccination induce T cells ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 7, 2024 Category: Research Authors: Eleonora Vecchio, Salvatore Rotundo, Claudia Veneziano, Antonio Abatino, Ilenia Aversa, Raffaella Gallo, Caterina Giordano, Francesca Serapide, Paolo Fusco, Giuseppe Viglietto, Giovanni Cuda, Francesco Costanzo, Alessandro Russo, Enrico Maria Trecarichi, Tags: Research Source Type: research
Myeloid leukemia-derived galectin-1 downregulates CAR expression to hinder cytotoxicity of CAR T cells
Chimeric antigen receptor (CAR) T cells have shown significant activity in B-lineage malignancies. However, their efficacy in myeloid leukemia has not been successful due to unclear molecular mechanisms. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 6, 2024 Category: Research Authors: Chuo Li, Shiyu Zuo, Lingling Shan, Huifang Huang, Haidong Cui and Xiaoming Feng Tags: Research Source Type: research
LIPCAR levels in plasma-derived extracellular vesicles is associated with left ventricle remodeling post-myocardial infarction
Long Intergenic noncoding RNA predicting CARdiac remodeling (LIPCAR) is a long noncoding RNA identified in plasma of patients after myocardial infarction (MI) to be associated with left ventricle remodeling (L... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 6, 2024 Category: Research Authors: Annie Turkieh, Olivia Beseme, Ouriel Saura, Henri Charrier, Jean-Baptiste Michel, Philippe Amouyel, Thomas Thum, Christophe Bauters and Florence Pinet Tags: Research Source Type: research
Noninvasive electrical stimulation as a neuroprotective strategy in retinal diseases: a systematic review of preclinical studies
Electrical activity has a crucial impact on the development and survival of neurons. Numerous recent studies have shown that noninvasive electrical stimulation (NES) has neuroprotective action in various retin... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 6, 2024 Category: Research Authors: Jiaxian Li, Wei Zhou, Lina Liang, Yamin Li, Kai Xu, Xiaoyu Li, Ziyang Huang and Yu Jin Tags: Review Source Type: research
Comprehensive genomic profiling on metastatic Melanoma: results from a network screening from 7 Italian Cancer Centres
The current therapeutic algorithm for Advanced Stage Melanoma comprises of alternating lines of Targeted and Immuno-therapy, mostly via Immune-Checkpoint blockade. While Comprehensive Genomic Profiling of soli... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 6, 2024 Category: Research Authors: Matteo Pallocca, Ivan Molineris, Enrico Berrino, Benedetta Marcozzi, Martina Betti, Lauretta Levati, Stefania D ’Atri, Chiara Menin, Gabriele Madonna, Paola Ghiorzo, Jenny Bulgarelli, Virgina Ferraresi, Tiziana Venesio, Monica Rodolfo, Licia Rivoltini, Tags: Research Source Type: research
