Recent advances of engineered oncolytic viruses-based combination therapy for liver cancer
Liver cancer is a major malignant tumor, which seriously threatens human health and increases the economic burden on patients. At present, gene therapy has been comprehensively studied as an excellent therapeu... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 2, 2024 Category: Research Authors: Junhe Zhang, Yunxi Xiao, Jie Zhang, Yun Yang, Liao Zhang and Fan Liang Tags: Review Source Type: research

TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis
Tandem C2 domains, nuclear (TC2N) is a C2 domain-containing protein that belongs to the carboxyl-terminal type (C-type) tandem C2 protein family, and acts as an oncogenic driver in several cancers. Previously,... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 2, 2024 Category: Research Authors: Xiang-lin Hao, Yang-fan Lv, De-feng Li, Fu-hai Bai, Ji Gong, Guang-qiang Pan, Lin-xi Su, Ya-li Wang, Wan-lei Fu, Bo Liu, Lu Huang, Dong Yan, Qiu-lin Tan, Jin-yi Liu and Qiao-nan Guo Tags: Research Source Type: research

Potential roles of the interactions between gut microbiota and metabolites in LPS-induced intrauterine inflammation (IUI) and associated preterm birth (PTB)
Prenatal exposure to intrauterine inflammation (IUI) is a crucial event in preterm birth (PTB) pathophysiology, increasing the incidence of neurodevelopmental disorders. Gut microbiota and metabolite profile a... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 2, 2024 Category: Research Authors: Bei Jia, Lijun Tang, Huibing Liu, Wenqian Chen, Qian Chen, Mei Zhong and Ailan Yin Tags: Research Source Type: research

NCAPG2 promotes prostate cancer malignancy and stemness via STAT3/c-MYC signaling
Prostate cancer (PCa) is the second leading cause of cancer-related mortality among men worldwide, and its incidence has risen substantially in recent years. Therefore, there is an urgent need to identify nove... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 2, 2024 Category: Research Authors: Enchong Zhang, Zhengjie Chen, Wangmin Liu, Lin Lin, Lina Wu, Johnny Guan, Jianfeng Wang, Chuize Kong, Jianbin Bi and Mo Zhang Tags: Research Source Type: research

Circulating small extracellular vesicles microRNAs plus CA-125 for treatment stratification in advanced ovarian cancer
No residual disease (R0 resection) after debulking surgery is the most critical independent prognostic factor for advanced ovarian cancer (AOC). There is an unmet clinical need for selecting primary or interva... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 22, 2023 Category: Research Authors: Xiaofang Zhou, Mu Liu, Lijuan Sun, Yumei Cao, Shanmei Tan, Guangxia Luo, Tingting Liu, Ying Yao, Wangli Xiao, Ziqing Wan and Jie Tang Tags: Research Source Type: research

From cells to organs: progress and potential in cartilaginous organoids research
While cartilage tissue engineering has significantly improved the speed and quality of cartilage regeneration, the underlying metabolic mechanisms are complex, making research in this area lengthy and challeng... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 21, 2023 Category: Research Authors: Xiao-he Wang, Ning Liu, Hui Zhang, Zong-sheng Yin and Zhen-Gang Zha Tags: Review Source Type: research

ALOX5 acts as a key role in regulating the immune microenvironment in intrahepatic cholangiocarcinoma, recruiting tumor-associated macrophages through PI3K pathway
Intrahepatic cholangiocarcinoma (ICC) is poorly treated due to the presence of an inhibitory immune microenvironment. Tumor-associated macrophages (TAM) are an important component of TME. ALOX5 is an important... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 20, 2023 Category: Research Authors: Jialu Chen, Yue Tang, Delong Qin, Xiaopeng Yu, Huanjun Tong, Chengwei Tang and Zhaohui Tang Tags: Research Source Type: research

Patient-derived scaffolds representing breast cancer microenvironments influence chemotherapy responses in adapted cancer cells consistent with clinical features
The tumor microenvironment clearly influences cancer progressing properties but less is known about how individual cancer microenvironments potentially moderate cancer treatment effects. By cultivating and tre... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 20, 2023 Category: Research Authors: Maria Carmen Leiva, Anna Gustafsson, Elena Garre, Anders St åhlberg, Anikó Kovács, Khalil Helou and Göran Landberg Tags: Research Source Type: research

Mitochondrion-targeted carboxymethyl chitosan hybrid nanoparticles loaded with Coenzyme Q10 protect cardiac grafts against cold ischaemia ‒reperfusion injury in heart transplantation
Heart transplantation (HT) has been approved as an optimal therapeutic regimen for patients with terminal-stage cardiac failure. However, cold ischaemia ‒reperfusion (I/R) injury remains an unavoidable and outs... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 20, 2023 Category: Research Authors: Shun Yuan, Yanjia Che, Zhiwei Wang, Kai Xing, Xiaoping Xie and Yuanyang Chen Tags: Research Source Type: research

Identifying the natural products in the treatment of atherosclerosis by increasing HDL-C level based on bioinformatics analysis, molecular docking, and in vitro experiment
Previous studies have demonstrated that high-density lipoprotein cholesterol (HDL-C) plays an anti-atherosclerosis role through reverse cholesterol transport. Several studies have validated the efficacy and sa... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 19, 2023 Category: Research Authors: Yilin Chen, Fengwei Zhang, Jijia Sun and Lei Zhang Tags: Research Source Type: research

Didymin alleviates metabolic dysfunction-associated fatty liver disease (MAFLD) via the stimulation of Sirt1-mediated lipophagy and mitochondrial biogenesis
Metabolic dysfunction-associated fatty liver disease (MAFLD) is one of the most prevalent metabolic syndromes worldwide. However, no approved pharmacological treatments are available for MAFLD. Chenpi, one kin... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 19, 2023 Category: Research Authors: Jing-wen Yang, Ying Zou, Jun Chen, Chen Cui, Jia Song, Meng-meng Yang, Jing Gao, Hui-qing Hu, Long-qing Xia, Li-ming Wang, Xiao-yu Lv, Li Chen and Xin-guo Hou Tags: Research Source Type: research

Phenylpropanoid-enriched broccoli seedling extract can reduce inflammatory markers and pain behavior
Pain is a worldwide problem requiring an effective, affordable, non-addictive therapy. Using the edible plant broccoli, a growth protocol was developed to induce a concentrated combinatorial of potential anti-... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 19, 2023 Category: Research Authors: Aleksandra A. Gurgul, Yahya Najjar, Ana Chee, Howard An, Chun-Tao Che, Thomas J. Park and Katherine M. Warpeha Tags: Research Source Type: research

Integrated plasma metabolomics and lipidomics profiling highlights distinctive signature of hepatocellular carcinoma in HCV patients
Early diagnosis of hepatocellular carcinoma (HCC) is essential towards the improvement of prognosis and patient survival. Circulating markers such as α-fetoprotein (AFP) and micro-RNAs represent useful tools b... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 18, 2023 Category: Research Authors: Vicky Caponigro, Anna L. Tornesello, Fabrizio Merciai, Danila La Gioia, Emanuela Salviati, Manuela G. Basilicata, Simona Musella, Francesco Izzo, Angelo S. Megna, Luigi Buonaguro, Eduardo Sommella, Franco M. Buonaguro, Maria L. Tornesello and Pietro Campi Tags: Research Source Type: research

Resurgence of syphilis: focusing on emerging clinical strategies and preclinical models
Syphilis, a sexually transmitted disease (STD) caused by Treponema pallidum (T. pallidum), has had a worldwide resurgence in recent years and remains a public health threat. As such, there has been a great deal o... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 18, 2023 Category: Research Authors: Shun Xiong, Zhaoping Liu, Xiaohong Zhang, Shaobin Huang, Xuan Ding, Jie Zhou, Jiangchen Yao, Weiwei Li, Shuangquan Liu and Feijun Zhao Tags: Review Source Type: research

Erbin accelerates TFEB-mediated lysosome biogenesis and autophagy and alleviates sepsis-induced inflammatory responses and organ injuries
Mounting attention has been focused on defects of the autophagy-lysosomal pathway in sepsis, however, the precise mechanisms governing the autophagy-lysosomal process in sepsis are poorly known. We have previo... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 17, 2023 Category: Research Authors: Qing Fang, Guoqing Jing, Ying Zhang, Hongyu Wang, Huan Luo, Yun Xia, Qiyan Jin, Yuping Liu, Jing Zuo, Cheng Yang, Xiaodong Zhang, Shi Liu, Xiaojing Wu and Xuemin Song Tags: Research Source Type: research