Association of the pathomics-collagen signature with lymph node metastasis in colorectal cancer: a retrospective multicenter study
Lymph node metastasis (LNM) is a prognostic biomarker and affects therapeutic selection in colorectal cancer (CRC). Current evaluation methods are not adequate for estimating LNM in CRC. H&E images contain muc... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 25, 2024 Category: Research Authors: Wei Jiang, Huaiming Wang, Xiaoyu Dong, Yandong Zhao, Chenyan Long, Dexin Chen, Botao Yan, Jiaxin Cheng, Zexi Lin, Shuangmu Zhuo, Hui Wang and Jun Yan Tags: Research Source Type: research
Synergistic use of anti-inflammatory ketorolac and gentamicin to target staphylococcal biofilms
While antibiotics remain our primary tools against microbial infection, increasing antibiotic resistance (inherent and acquired) is a major detriment to their efficacy. A practical approach to maintaining or r... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 25, 2024 Category: Research Authors: Amita Sekar, Dmitry Gil, Peyton Tierney, Madeline McCanne, Vikram Daesety, Darina Trendafilova, Orhun K. Muratoglu and Ebru Oral Tags: Research Source Type: research
Fbxw7 suppresses carcinogenesis and stemness in triple-negative breast cancer through CHD4 degradation and Wnt/ β-catenin pathway inhibition
Cancer stem cells (CSCs) are a small population of cells in tumor tissues that can drive tumor initiation and promote tumor progression. A small number of previous studies indirectly mentioned the role of F-bo... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 24, 2024 Category: Research Authors: Guodong Xiao, Weiping Lu, Jing Yuan, Zuyue Liu, Peili Wang and Huijie Fan Tags: Research Source Type: research
Asthma prediction via affinity graph enhanced classifier: a machine learning approach based on routine blood biomarkers
Asthma is a chronic respiratory disease affecting millions of people worldwide, but early detection can be challenging due to the time-consuming nature of the traditional technique. Machine learning has shown ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 24, 2024 Category: Research Authors: Dejing Li, Stanley Ebhohimhen Abhadiomhen, Dongmei Zhou, Xiang-Jun Shen, Lei Shi and Yubao Cui Tags: Research Source Type: research
SARS-CoV-2 neurovascular invasion supported by Mendelian randomization
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known to affect vessels and nerves and can be easily visualized in the retina. However, the effect of SARS-CoV-2 on retinal morphology remains co... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 24, 2024 Category: Research Authors: Yiji Pan, Jun Zhang and Tao He Tags: Research Source Type: research
Emerging applications of single-cell profiling in precision medicine of atherosclerosis
Atherosclerosis is a chronic, progressive, inflammatory disease that occurs in the arterial wall. Despite recent advancements in treatment aimed at improving efficacy and prolonging survival, atherosclerosis r... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 23, 2024 Category: Research Authors: Huiling Lin, Ming Zhang, Mi Hu, Yangkai Zhang, WeiWei Jiang, Wanying Tang, Yuxin Ouyang, Liping Jiang, Yali Mi, Zhi Chen, Pingping He, Guojun Zhao and Xinping Ouyang Tags: Review Source Type: research
The gut microbiota participates in the effect of linaclotide in patients with irritable bowel syndrome with constipation (IBS-C): a multicenter, prospective, pre-post study
Interindividual variation characterizes the relief experienced by constipation-predominant irritable bowel syndrome (IBS-C) patients following linaclotide treatment. Complex bidirectional interactions occur be... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 23, 2024 Category: Research Authors: Jianyun Zhou, Haoqi Wei, An Zhou, Xu Xiao, Xia Xie, Bo Tang, Hui Lin, Li Tang, Ruiping Meng, Xiaoying Yuan, Jing Zhang, Cheng Huang, Baobao Huang, Xiping Liao, Tingting Zhong, Suyu He & hellip; Tags: Research Source Type: research
A novel sub-regional radiomics model to predict immunotherapy response in non-small cell lung carcinoma
This study aimed to construct and investigate the potential performance of a ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 22, 2024 Category: Research Authors: Jie Peng, Dan Zou, Xudong Zhang, Honglian Ma, Lijie Han and Biao Yao Tags: Research Source Type: research
Prognostic and predictive value of super-enhancer-derived signatures for survival and lung metastasis in osteosarcoma
Risk stratification and personalized care are crucial in managing osteosarcoma due to its complexity and heterogeneity. However, current prognostic prediction using clinical variables has limited accuracy. Thu... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 22, 2024 Category: Research Authors: Guanyu Huang, Xuelin Zhang, Yu Xu, Shuo Chen, Qinghua Cao, Weihai Liu, Yiwei Fu, Qiang Jia, Jingnan Shen, Junqiang Yin and Jiajun Zhang Tags: Research Source Type: research
Intestinal microbiota and metabolome perturbations in ischemic and idiopathic dilated cardiomyopathy
Various clinical similarities are present in ischemic (ICM) and idiopathic dilated cardiomyopathy (IDCM), leading to ambiguity on some occasions. Previous studies have reported that intestinal microbiota appea... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 22, 2024 Category: Research Authors: Yusheng Wang, Yandan Xie, Gehendra Mahara, Yanling Xiong, Yalan Xiong, Qifang Zheng, Jianqin Chen, Wei Zhang, Honghao Zhou and Qing Li Tags: Research Source Type: research
A novel biomarker associated with EBV infection improves response prediction of immunotherapy in gastric cancer
Novel biomarkers are required in gastric cancer (GC) treated by immunotherapy. Epstein-Barr virus (EBV) infection induces an immune-active tumor microenvironment, while its association with immunotherapy respo... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 22, 2024 Category: Research Authors: Xiaoqin Li, Fen Xiong, Zhangmin Hu, Qing Tao, Yufei Yang, Xuehan Qiao, Chen Peng, Yuchun Jiang, Miao Han, Kebin Dong, Yi Hua, Wei Zhang, Min Xu, Weiguo Long, Yichuan Xiao and Deqiang Wang Tags: Research Source Type: research
Molecular Pathology
(Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 22, 2024 Category: Research Authors: Sarah Warren Tags: Editorial Source Type: research
Matrix stiffness affects tumor-associated macrophage functional polarization and its potential in tumor therapy
The extracellular matrix (ECM) plays critical roles in cytoskeletal support, biomechanical transduction and biochemical signal transformation. Tumor-associated macrophage (TAM) function is regulated by matrix ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 21, 2024 Category: Research Authors: Jiaqiang Xiong, Rourou Xiao, Jiahui Zhao, Qiuyan Zhao, Manwen Luo, Feng Li, Wei Zhang and Meng Wu Tags: Review Source Type: research
Integrating network pharmacology and animal experimental validation to investigate the action mechanism of oleanolic acid in obesity
Obesity, a condition associated with the development of widespread cardiovascular disease, metabolic disorders, and other health complications, has emerged as a significant global health issue. Oleanolic acid ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 21, 2024 Category: Research Authors: Tianfeng Liu, Jiliang Wang, Ying Tong, Lele Wu, Ying Xie, Ping He, Shujue Lin and Xuguang Hu Tags: Research Source Type: research
The integration of multidisciplinary approaches revealed PTGES3 as a novel drug target for breast cancer treatment
This study aimed to identify a novel molecular target that might be effec... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 20, 2024 Category: Research Authors: Qinan Yin, Haodi Ma, Yirui Dong, Shunshun Zhang, Junxiang Wang, Jing Liang, Longfei Mao, Li Zeng, Xin Xiong, Xingang Chen, Jingjing Wang and Xuewei Zheng Tags: Research Source Type: research
